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ICE family: ICESt1
ICESt1 is a well studied ICE. We selected it as a reference and defined ICESt1 family. We classified any ICE that encodes an integrase gene closely related to int(ICESt1) or int(ICESpn8140), defined as over 60% protein homology and that that has significant sequence alignment and syntenic 'core' structure into the ICESt1 family.

#IDICE nameStrainReplicon
178 experimental ICESt1Streptococcus thermophilus CNRZ368-
279 experimental ICESt3Streptococcus thermophilus CNRZ385-
380 in_silico ICESpn8140Streptococcus pneumoniae 8140-
4361 in_silico ICESpa15912-1Streptococcus parasanguinis ATCC 15912NC_015678
experimental Data derived from experimental literature
in_silico Putative ICEs predicted by bioinformatic methods
ElementNo. of sequencesDownloadAlignment
Proteins125FastaMultiple protein sequence alignment by MUSCLE online
ICEs4Fasta Nucleotide sequence comparison by webACT
(1) Carraro N et al. (2011). Differential regulation of two closely related integrative and conjugative elements from Streptococcus thermophilus. BMC Microbiol. 0.623611111. [PudMed:22024428] experimental
(2) Bellanger X et al. (2011). Site-specific accretion of an integrative conjugative element together with a related genomic island leads to cis mobilization and gene capture. Mol Microbiol. 81(4):912-25. [PudMed:21722203] experimental
(3) Croucher NJ et al. (2011). Rapid pneumococcal evolution in response to clinical interventions. Science. 331(6016):430-4. [PudMed:21273480] experimental
(4) Bellanger X et al. (2009). Conjugative transfer of the integrative conjugative elements ICESt1 and ICESt3 from Streptococcus thermophilus. J Bacteriol. 191(8):2764-75. [PudMed:19181800] experimental
(5) Bellanger X et al. (2008). Regulation of excision of integrative and potentially conjugative elements from Streptococcus thermophilus: role of the arp1 repressor. J Mol Microbiol Biotechnol. 14(1-3):16-21. [PudMed:17957106] experimental
(6) Bellanger X et al. (2007). Derepression of excision of integrative and potentially conjugative elements from Streptococcus thermophilus by DNA damage response: implication of a cI-related repressor. J Bacteriol. 189(4):1478-81. [PudMed:17114247] experimental
(7) Pavlovic G et al. (2004). Evolution of genomic islands by deletion and tandem accretion by site-specific recombination: ICESt1-related elements from Streptococcus thermophilus. Microbiology. 150(Pt 4):759-74. [PudMed:15073287] experimental
(8) Burrus V et al. (2002). The ICESt1 element of Streptococcus thermophilus belongs to a large family of integrative and conjugative elements that exchange modules and change their specificity of integration. Plasmid. 48(2):77-97. [PudMed:12383726] experimental in_silico
(9) Burrus V et al. (2001). Characterization of a novel type II restriction-modification system, Sth368I, encoded by the integrative element ICESt1 of Streptococcus thermophilus CNRZ368. Appl Environ Microbiol. 67(4):1522-8. [PudMed:11282600] experimental
(10) Burrus V et al. (2000). Characterization of a novel integrative element, ICESt1, in the lactic acid bacterium Streptococcus thermophilus. Appl Environ Microbiol. 66(4):1749-53. [PudMed:10742276] experimental
experimental experimental literature
in_silico in silico analysis literature