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ICE family: Tn916
The Tn916 family was defined by Roberts et al (2009). Elements belonging to the Tn916 family are defined by the following criteria: they must have the general organization shown in the following figure based on the figure from Roberts et al, and they must have a core region (conjugation and regulation module) that is similar in sequence and structure to the original Tn916 at the DNA level. Exceptions are some conjugative transposons, such as Tn1549 which have been previously classified in this family and those with a high degree of protein similarity as described in corresponding references.


#IDICE nameStrainReplicon
145 experimental Tn916Enterococcus faecalis DS16-
247 experimental Tn5251 (part of Tn5253)Streptococcus pneumoniae DP1322-
362 experimental CTn6002Streptococcus cristatus unknown strain(s)-
481 in_silico ICESpnMalM6Streptococcus pneumoniae Mal M6-
582 in_silico ICESpnH034800032Streptococcus pneumoniae H034800032-
683 in_silico ICESpn23771Streptococcus pneumoniae 23771-
785 in_silico ICESpn11930-2Streptococcus pneumoniae 11930-
886 in_silico ICESpn11928Streptococcus pneumoniae 11928-
987 in_silico ICESpn9409Streptococcus pneumoniae 9409-
1091 experimental Tn1545Streptococcus pneumoniae BM4200-
1192 experimental Tn1549Enterococcus faecalis BM4382-
1299 experimental Tn5381Enterococcus faecalis CH19-
13100 experimental Tn5383Enterococcus faecalis CH116-
14103 experimental Tn5397Clostridium difficile 630NC_009089
15104 experimental Tn6009Klebsiella pneumoniae 41-
16105 experimental Tn916SStreptococcus intermedius 15.3T.2-
17106 experimental Tn919Streptococcus sanguinis FC1-
18125 experimental CW459tet(M)Clostridium perfringens CW459-
19243 experimental ICELlapAA211Lactococcus lactis subsp. lactis plasmid pAA211-
20244 experimental ICELlapAA291Lactococcus lactis subsp. lactis plasmid pAA291-
21245 experimental ICESau8797Staphylococcus aureus 8797-
22246 experimental ICESau21995Staphylococcus aureus 21995-
23247 experimental ICESau35366Staphylococcus aureus 35366-
24248 experimental ICESau7413093Staphylococcus aureus 7413093-4-
25249 experimental ICESau7512166Staphylococcus aureus 7512166-1-
26250 experimental ICESau7312330Staphylococcus aureus 7312330-1-
27251 experimental ICESau9877324Staphylococcus aureus 9877324-3_H39-
28252 experimental ICESau35679Staphylococcus aureus 35679-
29253 experimental ICESau7412791Staphylococcus aureus 7412791-1-
30254 experimental ICESau7215311Staphylococcus aureus 7215311-1-
31255 experimental ICESausw356Staphylococcus aureus sw356-
32256 experimental ICESau7711730Staphylococcus aureus 7711730-1-
33257 experimental ICESau7413714Staphylococcus aureus 7413714-1-
34258 experimental ICESau7512986Staphylococcus aureus 7512986-1-
35259 experimental ICESau7612628Staphylococcus aureus 7612628-4-
36260 experimental ICESau35414Staphylococcus aureus 35414-
37261 experimental ICESau1591Staphylococcus aureus 1591-
38262 experimental ICESauST398Staphylococcus aureus MRSA_ST398_9b-
39263 experimental ICESau34801Staphylococcus aureus 34801-
40264 experimental ICESau617Staphylococcus aureus 617-
41265 experimental ICESau5377Staphylococcus aureus 5377-
42266 experimental ICESauusa42Staphylococcus aureus usa42-
43267 experimental ICESau7611280Staphylococcus aureus 7611280-5-
44268 experimental ICESau7215190Staphylococcus aureus 7215190-1-
45269 experimental ICESau22034Staphylococcus aureus 22034-
46270 experimental ICESau5331Staphylococcus aureus 5331-
47271 experimental ICESau4865Staphylococcus aureus 4865-
48272 experimental ICESau4520Staphylococcus aureus 4520-
49289 in_silico ICELm1Listeria monocytogenes EGD-eNC_003210
50303 experimental Tn916(pAM120)Cloning vector pAM120U49939
51304 in_silico ICESga43143-1Streptococcus gallolyticus subsp. gallolyticus ATCC 43143AP012053
52305 in_silico ICESauST398-1Staphylococcus aureus subsp. aureus ST398AM990992
53306 experimental Tn925Enterococcus faecalis plasmid pCF10NC_006827
54307 experimental Tn916(RST11)Staphylococcus rostri RST11-
55308 experimental ICESpaNUF1049Streptococcus parauberis NUF1049-
56309 in_silico ICESag2603VR-1Streptococcus agalactiae 2603V/RNC_004116
57310 in_silico ICESpsHKU1003-1Staphylococcus pseudintermedius HKU10-03NC_014925
58312 in_silico ICECloUPII95-1Clostridiales genomosp. BVAB3 str. UPII9-5NC_013895
59313 in_silico ICESsu98HAH33-1Streptococcus suis 98HAH33NC_009443
60314 in_silico ICECdiM68-1Clostridium difficile M68FN668375
61315 in_silico ICESorUo5-1Streptococcus oralis Uo5NC_015291
62316 in_silico ICESpnCGSP14-1Streptococcus pneumoniae CGSP14NC_010582
63318 experimental Tn6085bEnterococcus faecium C68-
64319 experimental Tn6085aEnterococcus faecium C68-
65320 in_silico ICESpnTw19F14-1Streptococcus pneumoniae Taiwan19F-14NC_012469
66321 experimental Tn6003Streptococcus pneumoniae Ar4-
67323 in_silico ICECdiM120-1Clostridium difficile M120FN665653
68324 in_silico ICESpnTCH8341-1Streptococcus pneumoniae TCH8431/19ANC_014251
69325 experimental Tn2010Streptococcus pneumoniae 05P294-
70326 experimental Tn6087Streptococcus oralis F.MI.5-
71327 in_silico ICEFal35896-1Filifactor alocis ATCC 35896CP002390
72328 experimental Tn6084Enterococcus faecium C68-
73329 Tn6079Uncultured bacterium MID12-
74330 experimental Tn3872Streptococcus pyogenes C-105-
75331 in_silico ICESpnH19A6-1Streptococcus pneumoniae Hungary19A-6NC_010380
76383 experimental ICEEfa9830414Enterococcus faecium 9830414-1-
77398 in_silico CTn1Clostridium difficile 630NC_009089
78399 in_silico CTn2Clostridium difficile 630NC_009089
79400 in_silico CTn4Clostridium difficile 630NC_009089
80401 in_silico CTn5Clostridium difficile 630NC_009089
81402 in_silico CTn6Clostridium difficile 630NC_009089
82403 in_silico CTn7Clostridium difficile 630NC_009089
experimental Data derived from experimental literature
in_silico Putative ICEs predicted by bioinformatic methods
ElementNo. of sequencesDownloadAlignment
Proteins0Fasta-
ICEs0Fasta-
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(36) Rocco JM et al. (2006). The integrase of the conjugative transposon Tn916 directs strand- and sequence-specific cleavage of the origin of conjugal transfer, oriT, by the endonuclease Orf20. J Bacteriol. 188(6):2207-13. [PudMed:16513750] experimental
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(40) Lancaster H et al. (2004). Characterization of Tn916S, a Tn916-like element containing the tetracycline resistance determinant tet(S). J Bacteriol. 186(13):4395-8. [PudMed:15205444] experimental
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(48) Connolly KM et al. (2002). Xis protein binding to the left arm stimulates excision of conjugative transposon Tn916. J Bacteriol. 184(8):2088-99. [PudMed:11914339] experimental
(49) Hinerfeld D et al. (2001). Xis protein of the conjugative transposon Tn916 plays dual opposing roles in transposon excision. Mol Microbiol. 41(6):1459-67. [PudMed:11580848] experimental
(50) Roberts AP et al. (2001). Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules. Microbiology. 147(Pt 5):1243-51. [PudMed:11320127] experimental
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(53) Wang H et al. (2000). The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397. J Bacteriol. 182(23):6577-83. [PudMed:11073898] experimental
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(55) Wang H et al. (2000). Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX. J Bacteriol. 182(13):3775-83. [PudMed:10850994] experimental
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(66) McDougal LK et al. (1998). Detection of Tn917-like sequences within a Tn916-like conjugative transposon (Tn3872) in erythromycin-resistant isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 42(9):2312-8. [PudMed:9736555] experimental
(67) Nelson KE et al. (1997). Tn916 transposition in Haemophilus influenzae Rd: preferential insertion into noncoding DNA. Microb Comp Genomics. 2(4):313-21. [PudMed:9689229] experimental
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(71) Rudy C et al. (1997). Excision of a conjugative transposon in vitro by the Int and Xis proteins of Tn916. Nucleic Acids Res. 25(20):4061-6. [PudMed:9321658] experimental
(72) Celli J et al. (1997). Use of an excision reporter plasmid to study the intracellular mobility of the conjugative transposon Tn916 in gram-positive bacteria. Microbiology. 143 ( Pt 4):1253-61. [PudMed:9141688] experimental
(73) Rudy CK et al. (1997). DNA binding by the Xis protein of the conjugative transposon Tn916. J Bacteriol. 179(8):2567-72. [PudMed:9098054] experimental
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(84) Jaworski DD et al. (1994). Evidence that coupling sequences play a frequency-determining role in conjugative transposition of Tn916 in Enterococcus faecalis. J Bacteriol. 176(11):3328-35. [PudMed:8195088] experimental
(85) Lu F et al. (1994). Conjugative transposition: Tn916 integrase contains two independent DNA binding domains that recognize different DNA sequences. EMBO J. 13(7):1541-8. [PudMed:8156992] experimental
(86) Flannagan SE et al. (1994). Nucleotide sequence of the 18-kb conjugative transposon Tn916 from Enterococcus faecalis. Plasmid. 32(3):350-4. [PudMed:7899523] experimental
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(88) Lu F et al. (1995). Tn916 target DNA sequences bind the C-terminal domain of integrase protein with different affinities that correlate with transposon insertion frequency. J Bacteriol. 177(8):1938-46. [PudMed:7721684] experimental
(89) Jaworski DD et al. (1995). A functional origin of transfer (oriT) on the conjugative transposon Tn916. J Bacteriol. 177(22):6644-51. [PudMed:7592445] experimental
(90) Nakayama J et al. (1994). The prgQ gene of the Enterococcus faecalis tetracycline resistance plasmid pCF10 encodes a peptide inhibitor, iCF10. J Bacteriol. 176(23):7405-8. [PudMed:7545961] experimental
(91) Manganelli R et al. (1995). Dosage of Tn916 circular intermediates in Enterococcus faecalis. Plasmid. 34(1):48-57. [PudMed:7480170] experimental
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