ICEberg
ICEberg ID181
Name10750-RD.2
FamilyTn1806
OrganismStreptococcus pyogenes MGAS10750
Size (bp)48521
GC content [Genome] (%)31 [38]
Insertion site-
FunctionType II restriction-modification system; spectinomycin resistance; erythromycin Resistance
Species that ICE can be transferred to-
Nucleotide SequenceCP000262 (ICE sequence without defined boundaries in this genome)
Replicon chromosome (1937111 bp, Project:16366) [NC_008024]
Genome coordinates1621728..1670248
Link to view genome context of this ICE in the genome browser
in_silico This is a predicted ICE derivied from literature.
Complete gene list of 10750-RD.2 form CP000262
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1hsdS1619589..1620764 [+], 117694548581 Type I restriction-modification system specificity subunit
2MGAS10750_Spy16781620777..1621568 [+], 79294548582 Type I restriction-modification system methylation subunit
3MGAS10750_Spy16791621728..1622501 [+], 77494548583  [UniProt]  [KEGG]phage protein
4MGAS10750_Spy16801622498..1623325 [+], 82894548584  [UniProt]  [KEGG]Replicative DNA helicase
5MGAS10750_Spy16811623318..1623803 [+], 48694548585  [UniProt]  [KEGG]hypothetical protein
6MGAS10750_Spy16821623800..1624534 [+], 73594548586  [UniProt]  [KEGG]phage antirepressor protein
7MGAS10750_Spy16831624512..1626323 [+], 181294548587  [UniProt]  [KEGG]TraG/TraD family
8MGAS10750_Spy16841626342..1626617 [+], 27694548588  [UniProt]  [KEGG]hypothetical protein
9MGAS10750_Spy16851626808..1627119 [+], 31294548589  [UniProt]  [KEGG]hypothetical protein
10MGAS10750_Spy16861627121..1627336 [+], 21694548590  [UniProt]  [KEGG]hypothetical protein
11MGAS10750_Spy16871627347..1628210 [+], 86494548591  [UniProt]  [KEGG]hypothetical protein
12MGAS10750_Spy16881628220..1628510 [+], 29194548592  [UniProt]  [KEGG]hypothetical protein
13MGAS10750_Spy16891628512..1628922 [+], 41194548593  [UniProt]  [KEGG]hypothetical protein
14MGAS10750_Spy16901628813..1630831 [+], 201994548594  [UniProt]  [KEGG]TrsE
15MGAS10750_Spy16911630788..1631237 [+], 45094548595  [UniProt]  [KEGG]TrsE
16MGAS10750_Spy16921631245..1633824 [+], 258094548596  [UniProt]  [KEGG]NlpC/P60 family proteinVF
17MGAS10750_Spy16931633839..1634078 [+], 24094548597  [UniProt]  [KEGG]hypothetical protein
18MGAS10750_Spy16941634065..1636416 [+], 235294548598  [UniProt]  [KEGG]Putative surface protein
19MGAS10750_Spy16951636431..1637300 [+], 87094548599  [UniProt]  [KEGG]hypothetical protein
20MGAS10750_Spy16961637352..1639085 [+], 173494548600  [UniProt]  [KEGG]DNA topoisomerase III
21MGAS10750_Spy16971639078..1640043 [+], 96694548601  [UniProt]  [KEGG]Type II restriction-modification system methylation subunit
22MGAS10750_Spy16981640030..1647673 [+], 764494548602  [UniProt]  [KEGG]Superfamily II DNA and RNA helicase
23MGAS10750_Spy16991647717..1648373 [+], 65794548603  [UniProt]  [KEGG]hypothetical protein
24MGAS10750_Spy17001648925..1649557 [+], 63394548604  [UniProt]  [KEGG]Transcriptional regulator, TetR familyVF
25MGAS10750_Spy17011649642..1650523 [+], 88294548605  [UniProt]  [KEGG]Tetronasin resistance ATP-binding protein
26MGAS10750_Spy17021650456..1652162 [+], 170794548606  [UniProt]  [KEGG]Tetronasin resistance transmembrane protein
27MGAS10750_Spy17041652743..1652949 [-], 20794548607  [UniProt]  [KEGG]hypothetical protein
28MGAS10750_Spy17031652896..1653627 [+], 73294548608  [UniProt]  [KEGG]rRNA adenine N-6-methyltransferaseAR
29MGAS10750_Spy17051653844..1654368 [+], 52594548609  [UniProt]  [KEGG]spectinomycin phosphotransferase
30MGAS10750_Spy17061654414..1654803 [+], 39094548610  [UniProt]  [KEGG]Cytidine deaminase
31MGAS10750_Spy17071654782..1655486 [+], 70594548611  [UniProt]  [KEGG]Zn-dependent hydrolase
32MGAS10750_Spy17081656371..1657465 [-], 109594548612  [UniProt]  [KEGG]Relaxase
33MGAS10750_Spy17091657466..1659343 [-], 187894548613  [UniProt]  [KEGG]Reverse transcriptase / RNA maturase / Endonuclease
34MGAS10750_Spy17101659807..1660178 [-], 37294548614  [UniProt]  [KEGG]Relaxase
35MGAS10750_Spy17111660180..1660638 [-], 45994548615  [UniProt]  [KEGG]hypothetical protein
36MGAS10750_Spy17121660707..1661801 [-], 109594548616  [UniProt]  [KEGG]RhuMVF
37MGAS10750_Spy17131662273..1662824 [-], 55294548617  [UniProt]  [KEGG]phage-related proteinTA
38MGAS10750_Spy17141662833..1663234 [-], 40294548618  [UniProt]  [KEGG]Transcriptional regulator, Cro/CI familyTA
39MGAS10750_Spy17151663384..1663944 [+], 56194548619  [UniProt]  [KEGG]hypothetical protein
40MGAS10750_Spy17161664213..1664623 [+], 41194548620  [UniProt]  [KEGG]hypothetical protein
41MGAS10750_Spy17171665419..1667092 [+], 167494548621  [UniProt]  [KEGG]Site-specific recombinase
42MGAS10750_Spy17181667092..1668762 [+], 167194548622  [UniProt]  [KEGG]Site-specific recombinase
43MGAS10750_Spy17191668755..1670248 [+], 149494548623  [UniProt]  [KEGG]Site-specific recombinase
44hsdM1670421..1671224 [+], 80494548624 Type I restriction-modification system methylation subunit
45MGAS10750_Spy17211671605..1671724 [+], 12094548625 hypothetical protein
46salR1671781..1672386 [-], 60694548626 Transcriptional regulatory protein degU
47MGAS10750_Spy17231672367..1673929 [-], 156394548627 Sensory transduction protein kinase
 
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins41Fasta
(1) Sitkiewicz I; Green NM; Guo N; Mereghetti L; Musser JM (2011). Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins. BMC Microbiol. 11:65. [PudMed:21457552] experimental
(2) Brenciani A; Tiberi E; Bacciaglia A; Petrelli D; Varaldo PE; Giovanetti E (2011). Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes. Antimicrob Agents Chemother. 55(5):2106-12. [PudMed:21343455] experimental
(3) Beres SB; Musser JM (2007). Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One. 2(8):e800. [PudMed:17726530]
 
experimental experimental literature