ICEberg
ICEberg ID191
Name10270-RD.2
Family10270-RD.2
OrganismStreptococcus pyogenes MGAS10270
Size (bp)34300
GC content [Genome] (%)35 [38]
Insertion site-
FunctionVirulence: encodes two cell surface anchored adhesins; Spy1399 and Spy1410.
Species that ICE can be transferred to-
Nucleotide SequenceCP000260 (complete ICE sequence in this genome)
Replicon chromosome (1928252 bp, Project:16364) [NC_008022]
Genome coordinates1312338..1346637
Link to view genome context of this ICE in the genome browser
in_silico This is a predicted ICE derivied from literature.
Complete gene list of 10270-RD.2 form CP000260
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1valS1307544..1310192 [-], 264994544390 Valyl-tRNA synthetase
2MGAS10270_Spy13741310194..1310778 [-], 58594544391 hypothetical protein
3MGAS10270_Spy13751310754..1310933 [-], 18094544392 Ribosomal-protein-serineacetyltransferase
4MGAS10270_Spy13761311358..1311753 [-], 39694544393 hypothetical cytosolic protein
5MGAS10270_Spy13771311771..1312025 [-], 25594544394 hypothetical protein
6int31312338..1313474 [-], 113794544395  [UniProt]  [KEGG]DNA integration/recombination/inversion protein
7MGAS10270_Spy13791313524..1313856 [-], 33394544396  [UniProt]  [KEGG]hypothetical protein
8MGAS10270_Spy13801314023..1314565 [-], 54394544397  [UniProt]  [KEGG]hypothetical membrane spanning protein
9MGAS10270_Spy13811314788..1315549 [-], 76294544398  [UniProt]  [KEGG]Cell surface protein
10MGAS10270_Spy13821315574..1316131 [-], 55894544399  [UniProt]  [KEGG]hypothetical exported protein
11MGAS10270_Spy13831316131..1317489 [-], 135994544400  [UniProt]  [KEGG]hypothetical exported protein
12MGAS10270_Spy13841317624..1317767 [+], 14494544401  [UniProt]  [KEGG]hypothetical protein
13MGAS10270_Spy13851317935..1320250 [-], 231694544402  [UniProt]  [KEGG]Membrane protein
14MGAS10270_Spy13861320265..1322766 [-], 250294544403  [UniProt]  [KEGG]DNA segregation ATPase
15MGAS10270_Spy13871322787..1323197 [-], 41194544404  [UniProt]  [KEGG]hypothetical protein
16MGAS10270_Spy13881323200..1323469 [-], 27094544405  [UniProt]  [KEGG]hypothetical membrane spanning protein
17MGAS10270_Spy13891323488..1324438 [-], 95194544406  [UniProt]  [KEGG]hypothetical protein
18MGAS10270_Spy13901324439..1324918 [-], 48094544407  [UniProt]  [KEGG]hypothetical protein
19MGAS10270_Spy13911324926..1325177 [-], 25294544408  [UniProt]  [KEGG]hypothetical protein
20MGAS10270_Spy13921325207..1325416 [-], 21094544409  [UniProt]  [KEGG]hypothetical protein
21MGAS10270_Spy13931325460..1325732 [-], 27394544410  [UniProt]  [KEGG]hypothetical protein
22MGAS10270_Spy13941326121..1326498 [-], 37894544411  [UniProt]  [KEGG]hypothetical cytosolic protein
23MGAS10270_Spy13951326499..1327740 [-], 124294544412  [UniProt]  [KEGG]Transcriptional regulator, Cro/CI family
24MGAS10270_Spy13961328052..1329761 [-], 171094544413  [UniProt]  [KEGG]FtsK/SpoIIIE family
25MGAS10270_Spy13971329781..1330236 [-], 45694544414  [UniProt]  [KEGG]hypothetical cytosolic protein
26MGAS10270_Spy13981330239..1330544 [-], 30694544415  [UniProt]  [KEGG]hypothetical cytosolic protein
27MGAS10270_Spy13991330806..1334864 [-], 405994544416  [UniProt]  [KEGG]Cell surface protein
28MGAS10270_Spy14001335034..1337274 [-], 224194544417  [UniProt]  [KEGG]M protein
29MGAS10270_Spy14011337367..1337759 [-], 39394544418  [UniProt]  [KEGG]hypothetical cytosolic protein
30MGAS10270_Spy14021337883..1338323 [-], 44194544419  [UniProt]  [KEGG]Glutaredoxin-like protein
31MGAS10270_Spy14031338481..1338915 [-], 43594544420  [UniProt]  [KEGG]Transcriptional regulator, Cro/CI family
32MGAS10270_Spy14041339790..1340176 [+], 38794544421  [UniProt]  [KEGG]Transcriptional regulator, Cro/CI familyTA
33MGAS10270_Spy14051340183..1340605 [+], 42394544422  [UniProt]  [KEGG]hypothetical cytosolic proteinTA
34MGAS10270_Spy14061340670..1341026 [-], 35794544423  [UniProt]  [KEGG]hypothetical exported protein
35MGAS10270_Spy14071341029..1341367 [-], 33994544424  [UniProt]  [KEGG]hypothetical cytosolic protein
36MGAS10270_Spy14081341364..1341657 [-], 29494544425  [UniProt]  [KEGG]DNA-damage-inducible protein J
37MGAS10270_Spy14091341678..1341863 [+], 18694544426  [UniProt]  [KEGG]Transposase
38MGAS10270_Spy14101342369..1345203 [-], 283594544427  [UniProt]  [KEGG]Cell surface proteinVF
39MGAS10270_Spy14111345432..1346637 [+], 120694544428  [UniProt]  [KEGG]Transcriptional regulator, AraC family
40MGAS10270_Spy14121347155..1347907 [+], 75394544429 3-deoxy-7-phosphoheptulonate synthase
41aroB1347948..1349036 [+], 108994544430 3-dehydroquinate synthase
42MGAS10270_Spy14141349306..1349464 [-], 15994544431 hypothetical protein
43MGAS10270_Spy14151349472..1349777 [-], 30694544432 Putative acetate kinase
44MGAS10270_Spy14161349779..1350117 [-], 33994544433 hypothetical cytosolic protein
45MGAS10270_Spy14171350170..1350925 [-], 75694544434 SAM-dependent methyltransferase
 
flank Flanking regions
integrase Gene may contribute to site-specific recombination

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins34Fasta
(1) Sitkiewicz I; Green NM; Guo N; Mereghetti L; Musser JM (2011). Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins. BMC Microbiol. 11:65. [PudMed:21457552] experimental
(2) Beres SB; Musser JM (2007). Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One. 2(8):e800. [PudMed:17726530]
 
experimental experimental literature