ICEberg ID74
OrganismEscherichia coli IHE3034
Size (bp)54445
GC content [Genome] (%)
Insertion sitetRNA-Asn
FunctionBiosynthesis and secretion pathway of putative hybrid nonribosomal peptidepolyketide colibactin
Species that ICE can be transferred toEnterobacteriaceae
Nucleotide SequenceAM229678 (complete ICE sequence in this GenBank file)
Link to view genome context of this ICE in the genome browser
experimental This is a ICE derived from experimental literature.
Complete gene list of ICEEcIHE3034-1 form AM229678
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1intP4469..1740 [+], 1272112292701  [UniProt] bacteriophage integraseVF
2-2020..2532 [-], 513112292702  [UniProt] hypothetical protein
3clbQ2567..3289 [-], 723112292703  [UniProt] putative thioesterase
4clbP3282..4796 [-], 1515112292704  [UniProt] putative penicillin binding protein
5clbO4809..7268 [-], 2460112292705  [UniProt] putative polyketide synthaseVF
6clbN7299..11666 [-], 4368112292706  [UniProt] putative non-ribosomal peptide synthetase
7clbM11663..13102 [-], 1440112292707  [UniProt] putative drug/sodium antiporter
8clbL13164..14627 [-], 1464112292708  [UniProt] putative amidase
9clbK14620..21084 [-], 6465112292709  [UniProt] putative hybrid non-ribosomal peptide-polyketide synthetase
10clbJ21095..27595 [-], 6501112292710  [UniProt] putative non-ribosomal peptide synthaseVF
11clbI27639..30671 [-], 3033112292711  [UniProt] putative polyketide synthaseVF
12clbH30721..35517 [-], 4797112292712  [UniProt] putative non-ribosomal peptide synthase
13clbG35565..36833 [-], 1269112292713  [UniProt] putative malonyl-CoA transacylase
14clbF36830..37960 [-], 1131112292714  [UniProt] putative acyl-CoA dehydrogenase
15clbE37964..38212 [-], 249112292715  [UniProt] putative D-alanyl carrier protein
16clbD38242..39111 [-], 870112292716  [UniProt] putative 3-hydroxyacyl-CoA dehydrogenase
17clbC39121..41721 [-], 2601112292717  [UniProt] putative polyketide synthaseVF
18clbB41762..51382 [-], 9621112292718  [UniProt] putative hybrid polyketide-non-ribosomal peptide synthetase
19clbR51840..52052 [+], 213112292719  [UniProt] putative regulatory proteinVF
20clbA52053..52787 [+], 735112292720  [UniProt] putative 4'-phosphopantetheinyl transferase
21-52933..53199 [+], 267112292721  [UniProt] IS1400 transposase A
22-53304..53783 [+], 480112292722  [UniProt] IS1400 transposase B
23-53774..54001 [+], 228112292723  [UniProt] putative transposaseVF
integrase Gene may contribute to site-specific recombination
VF: Blastp hit against the virulence factor database VFDB.

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
(1) Putze J; Hennequin C; Nougayrede JP; Zhang W; Homburg S; Karch H; Bringer MA; Fayolle C; Carniel E; Rabsch W; Oelschlaeger TA; Oswald E; Forestier C; Hacker J; Dobrindt U (2009). Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect Immun. 77(11):4696-703. [PudMed:19720753] experimental in_silico
(2) Nougayrede JP; Homburg S; Taieb F; Boury M; Brzuszkiewicz E; Gottschalk G; Buchrieser C; Hacker J; Dobrindt U; Oswald E (2006). Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 313(5788):848-51. [PudMed:16902142] experimental
experimental experimental literature
in_silico in silico analysis literature