ICEberg
ICEberg ID74
NameICEEcIHE3034-1
FamilyUnclassified
OrganismEscherichia coli IHE3034
Size (bp)54445
GC content [Genome] (%)
Insertion sitetRNA-Asn
FunctionBiosynthesis and secretion pathway of putative hybrid nonribosomal peptidepolyketide colibactin
Species that ICE can be transferred toEnterobacteriaceae
Nucleotide SequenceAM229678 (complete ICE sequence in this GenBank file)
Replicon-
Coordinates292..54752
Link to view genome context of this ICE in the genome browser
experimental This is a ICE derived from experimental literature.
Complete gene list of ICEEcIHE3034-1 form AM229678
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1intP4469..1740 [+], 1272112292701  [UniProt] bacteriophage integraseVF
2-2020..2532 [-], 513112292702  [UniProt] hypothetical protein
3clbQ2567..3289 [-], 723112292703  [UniProt] putative thioesterase
4clbP3282..4796 [-], 1515112292704  [UniProt] putative penicillin binding protein
5clbO4809..7268 [-], 2460112292705  [UniProt] putative polyketide synthaseVF
6clbN7299..11666 [-], 4368112292706  [UniProt] putative non-ribosomal peptide synthetase
7clbM11663..13102 [-], 1440112292707  [UniProt] putative drug/sodium antiporter
8clbL13164..14627 [-], 1464112292708  [UniProt] putative amidase
9clbK14620..21084 [-], 6465112292709  [UniProt] putative hybrid non-ribosomal peptide-polyketide synthetase
10clbJ21095..27595 [-], 6501112292710  [UniProt] putative non-ribosomal peptide synthaseVF
11clbI27639..30671 [-], 3033112292711  [UniProt] putative polyketide synthaseVF
12clbH30721..35517 [-], 4797112292712  [UniProt] putative non-ribosomal peptide synthase
13clbG35565..36833 [-], 1269112292713  [UniProt] putative malonyl-CoA transacylase
14clbF36830..37960 [-], 1131112292714  [UniProt] putative acyl-CoA dehydrogenase
15clbE37964..38212 [-], 249112292715  [UniProt] putative D-alanyl carrier protein
16clbD38242..39111 [-], 870112292716  [UniProt] putative 3-hydroxyacyl-CoA dehydrogenase
17clbC39121..41721 [-], 2601112292717  [UniProt] putative polyketide synthaseVF
18clbB41762..51382 [-], 9621112292718  [UniProt] putative hybrid polyketide-non-ribosomal peptide synthetase
19clbR51840..52052 [+], 213112292719  [UniProt] putative regulatory proteinVF
20clbA52053..52787 [+], 735112292720  [UniProt] putative 4'-phosphopantetheinyl transferase
21-52933..53199 [+], 267112292721  [UniProt] IS1400 transposase A
22-53304..53783 [+], 480112292722  [UniProt] IS1400 transposase B
23-53774..54001 [+], 228112292723  [UniProt] putative transposaseVF
 
integrase Gene may contribute to site-specific recombination
VF: Blastp hit against the virulence factor database VFDB.

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
Proteins23Fasta
(1) Putze J; Hennequin C; Nougayrede JP; Zhang W; Homburg S; Karch H; Bringer MA; Fayolle C; Carniel E; Rabsch W; Oelschlaeger TA; Oswald E; Forestier C; Hacker J; Dobrindt U (2009). Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect Immun. 77(11):4696-703. [PudMed:19720753] experimental in_silico
(2) Nougayrede JP; Homburg S; Taieb F; Boury M; Brzuszkiewicz E; Gottschalk G; Buchrieser C; Hacker J; Dobrindt U; Oswald E (2006). Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 313(5788):848-51. [PudMed:16902142] experimental
 
experimental experimental literature
in_silico in silico analysis literature