ICEberg
ICEberg ID91
NameTn1545
FamilyTn916
OrganismStreptococcus pneumoniae BM4200
Size (bp)-
GC content [Genome] (%)-
Insertion site-
FunctionResistance to sulfamethoxazole, trimethoprim, chloramphenicol, erythromycin, and streptomycin
Species that ICE can be transferred toEnterococcus faecalis; Listeria monocytogenes;Enterococcus faecium
Nucleotide SequenceAM889142; AM903082 (partical ICE sequence)
experimental This is a ICE derived from experimental literature.
Incomplete gene list of Tn1545 from AM903082
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1-665..748 [+], 84162286805  [UniProt] MLS leader peptide
2ermB873..1608 [+], 736pseudogene erythromycin ribosome methylase
3sat42008..2538 [+], 531162286806  [UniProt] streptothricin acetyltransferase
4aphA-32631..3425 [+], 795162286807  [UniProt] aminoglycoside phosphotransferase type IIIAR
5-3756..4274 [+], 519162286808  [UniProt] hypothetical protein
6-4893..4976 [+], 84162286809  [UniProt] hypothetical protein
7ermB5101..5838 [+], 738162286810  [UniProt] erythromycin ribosome methylaseAR
8-5783..5974 [+], 192162286811  [UniProt] hypothetical protein
9tnp6095..7342 [-], 1248162286812  [UniProt] putative transposase
10-7522..7743 [+], 222162286813  [UniProt] hypothetical protein
Incomplete gene list of Tn1545 from AM889142
#GeneCoordinates [+/-], size (bp)Protein GI Product *
1tnp52..1005 [-], 954161784419  [UniProt] putative IS1239 transposase
2-1516..1602 [+], 87168478964  [UniProt] tet(M) leader peptide
3tet(M)1618..3537 [+], 1920168478965  [UniProt] tetracycline resistance protein TetMAR
 
AR: Blastp hit against the antibiotic resistance gene database ARDB.

ElementNo. of sequencesDownload
Nucleotide sequences2Fasta
Proteins12Fasta
(1) Shen X; Yang H; Yu S; Yao K; Wang Y; Yuan L; Yang Y (2008). Macrolide-resistance mechanisms in Streptococcus pneumoniae isolates from Chinese children in association with genes of tetM and integrase of conjugative transposons 1545. Microb Drug Resist. 14(2):155-61. [PudMed:18479199] experimental
(2) Seral C; Castillo FJ; Garcia C; Rubio-Calvo MC; Gomez-Lus R (2000). [Presence of conjugative transposon Tn1545 in strains of Streptococcus pneumoniae with mef(A), erm(B), tet(M), catpC194 and aph3'-III genes]. Enferm Infecc Microbiol Clin. 18(10):506-11. [PudMed:11198001] experimental
(3) Woolley RC; Pennock A; Ashton RJ; Davies A; Young M (1989). Transfer of Tn1545 and Tn916 to Clostridium acetobutylicum. Plasmid. 22(2):169-74. [PudMed:2560219] experimental
(4) Poyart-Salmeron C; Trieu-Cuot P; Carlier C; Courvalin P (1989). Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinases. EMBO J. 8(8):2425-33. [PudMed:2551683] experimental
(5) Trieu-Cuot P; Poyart-Salmeron C; Carlier C; Courvalin P (1990). Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. Nucleic Acids Res. 18(12):3660. [PudMed:2163525] experimental
(6) Poyart-Salmeron C; Trieu-Cuot P; Carlier C; Courvalin P (1990). The integration-excision system of the conjugative transposon Tn 1545 is structurally and functionally related to those of lambdoid phages. Mol Microbiol. 4(9):1513-21. [PudMed:1962839] experimental
(7) Doucet-Populaire F; Trieu-Cuot P; Dosbaa I; Andremont A; Courvalin P (1991). Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice. Antimicrob Agents Chemother. 35(1):185-7. [PudMed:1849709] experimental
 
experimental experimental literature