SecReT4
T4SS ID159
StrainCoxiella burnetii CbuG_Q212
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_011527
Location336565..370332
NameDot/Icm
Functioneffector translocation
ClassificationType IVB; Type I
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentDotADotBDotCDotDIcmBIcmCIcmDIcmEIcmF
Number111111110
ComponentIcmGIcmHIcmJIcmKIcmLIcmMIcmNIcmOIcmP
Number101120111
ComponentIcmQIcmRIcmSIcmTIcmVIcmWIcmXLvgA
Number10111110

The information of T4SS components from NC_011527
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1CbuG_0361332651..332770 [+], 120212212004hypothetical protein 
2CbuG_0362 (rfaE)332778..334268 [+], 1491212212005bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 
3CbuG_0363334293..334475 [-], 183212212006virulence-associated protein C 
4CbuG_0364334600..334944 [+], 345212212007hypothetical protein 
5CbuG_0365334941..336035 [-], 1095212212008transposase 
6CbuG_0367 (icmX)336565..337695 [-], 1131212212009IcmX  IcmX
7CbuG_0368337711..338169 [-], 459212212010hypothetical membrane-associated protein 
8CbuG_0369 (icmW)338166..338615 [-], 450212212011IcmW  IcmW
9CbuG_0370 (icmV)338805..339299 [+], 495212212012IcmV  IcmV
10CbuG_0371 (dotA)339296..341740 [+], 2445212212013DotA  DotA
11CbuG_0372341795..341890 [+], 96212212014hypothetical protein 
12CbuG_0373342124..342396 [+], 273212212015hypothetical protein 
13CbuG_0374342393..343487 [-], 1095212212016transposase 
14CbuG_0375343589..344923 [-], 1335212212017glycine betaine transporter 
15CbuG_0376 (dotB)344930..346048 [-], 1119212212018ATP-binding protein  DotB
16CbuG_0377 (dotC)346086..346910 [-], 825212212019DotC  DotC
17CbuG_0378 (dotD)346913..347422 [-], 510212212020DotD  DotD
18CbuG_0379 (icmS)347579..347917 [-], 339212212021IcmS  IcmS
19CbuG_0380 (icmT)347917..348174 [-], 258212212022IcmT  IcmT
20CbuG_0381348290..349384 [+], 1095212212023transposase 
21CbuG_0382349381..349716 [-], 336212212024hypothetical protein 
22CbuG_0384351177..352382 [+], 1206212212025ATPase 
23CbuG_0385352479..352616 [-], 138212212026hypothetical protein 
24CbuG_0387353978..354151 [-], 174212212027hypothetical protein 
25CbuG_0388354267..354416 [+], 150212212028hypothetical protein 
26CbuG_0389 (icmQ)354413..355129 [+], 717212212029IcmQ  IcmQ
27CbuG_0390 (icmP)355130..356293 [+], 1164212212030IcmP  IcmP
28CbuG_0391 (icmO)356269..358647 [+], 2379212212031IcmO  IcmO
29CbuG_0392 (icmN)358657..359295 [+], 639212212032IcmN protein, OmpA family  IcmN
30CbuG_0393 (icmL.1)359302..359925 [+], 624212212033IcmL  IcmL
31CbuG_0394 (icmL.2)359927..360583 [+], 657212212034IcmL  IcmL
32CbuG_0395 (icmK)360594..361649 [+], 1056212212035IcmK  IcmK
33CbuG_0396 (icmE)361636..364755 [+], 3120212212036IcmE  IcmE
34CbuG_0397 (icmG)364773..365507 [+], 735212212037IcmG  IcmG
35CbuG_0398 (icmC)365578..366087 [+], 510212212038IcmC  IcmC
36CbuG_0399 (icmD)366181..366597 [+], 417212212039IcmD  IcmD
37CbuG_0400 (icmJ)366610..367248 [+], 639212212040IcmJ  IcmJ
38CbuG_0401 (icmB)367321..370332 [+], 3012212212041IcmB  IcmB
39CbuG_0402370347..370484 [-], 138212212042hypothetical protein 
40CbuG_0403370702..371235 [-], 534212212043hypothetical protein 
41CbuG_0404371292..371645 [-], 354212212044hypothetical protein 
42CbuG_0405371775..371909 [+], 135212212045hypothetical protein 
43CbuG_0406371938..372552 [+], 615212212046ankyrin repeat protein 
44CbuG_0407372846..373229 [+], 384212212047hypothetical protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes

Effectors
CbuG_0006, CbuG_0092, CbuG_0133, AnkM, AnkM, CbuG_0140, CbuG_0151, CbuG_0157, CbuG_0164, CbuG_0197, CbuG_0272, CbuG_0282, CbuG_0309, CbuG_0360, CbuG_0365, CbuG_0374, CbuG_0381, CbuG_0419, CbuG_0440, CbuG_0454, CbuG_0467, CbuG_0468, CbuG_0477, CbuG_0479, CbuG_0486, CbuG_0530, CbuG_0554, CbuG_0582, CbuG_0591, CbuG_0633, CbuG_0641, CbuG_0696, CbuG_0739, AnkI, CbuG_0793, AnkI, CbuG_0824, CbuG_0927, CbuG_0958, CbuG_0959, AnkH, CbuG_1068, CbuG_1121, CbuG_1199, CbuG_1207, AnkG, CbuG_1369, CbuG_1400, CbuG_1471, AnkN, AnkF, CbuG_1587, CbuG_1597, CbuG_1602, CbuG_1603, CbuG_1606, CbuG_1625, CbuG_1711, CbuG_1738, CbuG_1837, CbuG_1886, CbuG_1937, CbuG_1938, CbuG_1943, CbuG_1970, CbuG_1971, CbuG_1996, CbuG_2057, CbuG_2064, CbuG_2079

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1CbuG_0006 6699..7793 [+], 1095212211674transposase  CbuG_0006
2CbuG_0092 78021..79115 [+], 1095212211756transposase  CbuG_0092
3CbuG_0133 121318..122580 [+], 1263212211793hypothetical protein  CbuG_0133
4CbuG_0137 124971..125096 [-], 126212211796hypothetical protein  AnkM
5CbuG_0139 126339..128735 [-], 2397212211798ankyrin repeat protein  AnkM
6CbuG_0140 129016..130080 [+], 1065212211799transposase  CbuG_0140
7CbuG_0151 139597..140214 [-], 618212211810alpha/beta hydrolase  CbuG_0151
8CbuG_0157 145769..146863 [+], 1095212211816transposase  CbuG_0157
9CbuG_0164 154757..155851 [+], 1095212211822transposase  CbuG_0164
10CbuG_0197 190298..190717 [+], 420212211853hypothetical protein  CbuG_0197
11CbuG_0272 254988..256082 [+], 1095212211921transposase  CbuG_0272
12CbuG_0282 261523..262776 [-], 1254212211929low-affinity inorganic phosphate transporter  CbuG_0282
13CbuG_0309 284924..286018 [+], 1095212211955transposase  CbuG_0309
14CbuG_0360 331527..332621 [-], 1095212212003transposase  CbuG_0360
15CbuG_0365 334941..336035 [-], 1095212212008transposase  CbuG_0365
16CbuG_0374 342393..343487 [-], 1095212212016transposase  CbuG_0374
17CbuG_0381 348290..349384 [+], 1095212212023transposase  CbuG_0381
18CbuG_0419 386543..387637 [+], 1095212212056transposase  CbuG_0419
19CbuG_0440 404683..405747 [+], 1065212212077transposase  CbuG_0440
20CbuG_0454 418055..419761 [-], 1707212212089hypothetical membrane spanning protein  CbuG_0454
21CbuG_0467 432926..433444 [+], 519212212100hypothetical protein  CbuG_0467
22CbuG_0468 433550..433693 [-], 144212212101hypothetical protein  CbuG_0468
23CbuG_0477 442221..443552 [-], 1332212212109hypothetical membrane spanning protein  CbuG_0477
24CbuG_0479 443733..444827 [+], 1095212212111transposase  CbuG_0479
25CbuG_0486 453467..454108 [-], 642212212117hypothetical protein  CbuG_0486
26CbuG_0530 493137..494231 [-], 1095212212158transposase  CbuG_0530
27CbuG_0554 515059..517071 [+], 2013212212178tetratricopeptide repeat family protein  CbuG_0554
28CbuG_0582 547166..548260 [-], 1095212212203transposase  CbuG_0582
29CbuG_0591 556630..557082 [+], 45321221221117 kDa common-antigen  CbuG_0591
30CbuG_0633 596477..598336 [+], 1860212212250protein kinase family  CbuG_0633
31CbuG_0641 605276..606370 [-], 1095212212257transposase  CbuG_0641
32CbuG_0696 662683..663399 [+], 717212212306hypothetical cytosolic protein  CbuG_0696
33CbuG_0739 707980..709074 [+], 1095212212345transposase  CbuG_0739
34CbuG_0789 761984..762577 [+], 594212212394hypothetical membrane spanning protein  AnkI
35CbuG_0793 764794..765888 [-], 1095212212398transposase  CbuG_0793
36CbuG_0798 769864..772044 [-], 2181212212400ankyrin repeat protein  AnkI
37CbuG_0824 799300..800394 [-], 1095212212425transposase  CbuG_0824
38CbuG_0927 900755..901849 [+], 1095212212510transposase  CbuG_0927
39CbuG_0958 934316..934429 [+], 114212212534hypothetical protein  CbuG_0958
40CbuG_0959 934499..936247 [-], 1749212212535hypothetical protein  CbuG_0959
41CbuG_0984 960202..960507 [-], 306212212552hypothetical protein  AnkH
42CbuG_1068 1031373..1032824 [-], 1452212212618hypothetical protein  CbuG_1068
43CbuG_1121 1080126..1080791 [+], 666212212667hypothetical cytosolic protein  CbuG_1121
44CbuG_1199 (rimI)1163944..1164318 [-], 375212212739ribosomal-protein-S18-alanine acetyltransferase  CbuG_1199
45CbuG_1207 1168873..1170330 [+], 1458212212746hypothetical protein  CbuG_1207
46CbuG_1220 1189264..1190280 [-], 1017212212757ankyrin repeat protein  AnkG
47CbuG_1369 1326177..1327667 [-], 1491212212884hypothetical membrane spanning protein  CbuG_1369
48CbuG_1400 1361962..1363056 [-], 1095212212912transposase  CbuG_1400
49CbuG_1471 1439686..1440780 [+], 1095212212979transposase  CbuG_1471
50CbuG_1487 1457953..1459542 [-], 1590212212992ankyrin repeat protein  AnkN
51CbuG_1564 1526684..1527238 [+], 555212213067ankyrin repeat protein  AnkF
52CbuG_1587 1542246..1543730 [+], 1485212213089hypothetical protein  CbuG_1587
53CbuG_1597 1550757..1551920 [-], 1164212213097hypothetical cytosolic protein  CbuG_1597
54CbuG_1602 1553162..1554256 [-], 1095212213101transposase  CbuG_1602
55CbuG_1603 1554452..1556188 [+], 1737212213102hypothetical membrane spanning protein  CbuG_1603
56CbuG_1606 1557121..1557222 [+], 102212213105hypothetical protein  CbuG_1606
57CbuG_1625 1576165..1577259 [-], 1095212213120transposase  CbuG_1625
58CbuG_1711 (algC)1660737..1662152 [-], 1416212213196phosphoglucomutase  CbuG_1711
59CbuG_1738 1679967..1681187 [-], 1221212213222trans-2-enoyl-CoA reductase  CbuG_1738
60CbuG_1837 1765860..1766600 [-], 741212213303serine/threonine protein kinase domain protein  CbuG_1837
61CbuG_1886 1815269..1816582 [-], 1314212213343hypothetical protein  CbuG_1886
62CbuG_1937 1859530..1860417 [-], 888212213391hypothetical transcriptional regulatory protein  CbuG_1937
63CbuG_1938 1860593..1861384 [-], 792212213392hypothetical membrane spanning protein  CbuG_1938
64CbuG_1943 1866082..1867176 [+], 1095212213397transposase  CbuG_1943
65CbuG_1970 1890490..1892622 [+], 2133212213421hypothetical protein  CbuG_1970
66CbuG_1971 1892811..1893422 [+], 612212213422hypothetical cytosolic protein  CbuG_1971
67CbuG_1996 1913951..1915045 [+], 1095212213447transposase  CbuG_1996
68CbuG_2057 1971797..1972441 [-], 645212213502hypothetical protein  CbuG_2057
69CbuG_2064 1981226..1981363 [-], 138212213507hypothetical protein  CbuG_2064
70CbuG_2079 1993183..1994229 [-], 1047212213521Fic family protein  CbuG_2079

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Proteins        Genes
(1) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632]
(2) Chen C; Banga S; Mertens K; Weber MM; Gorbaslieva I; Tan Y; Luo ZQ; Samuel JE (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666] experimental
(3) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324] experimental
(4) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289] experimental in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation