SecReT4
T4SS ID2
StrainBartonella henselae str. Houston-1
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_005956
Location1512780..1525452
NameVirB
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentVirB1VirB2VirB3VirB4VirB5VirB6VirB7VirB8VirB9
Number011111111
ComponentVirB10VirB11VirD4
Number111

The information of T4SS components from NC_005956
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1BH132501511669..1512412 [-], 74449476009hypothetical protein 
2BH13260 (virB2)1512780..1513103 [+], 32449476010virB2 protein  VirB2
3BH13270 (virB3)1513104..1513415 [+], 31249476011virB3 protein  VirB3
4BH13280 (virB4)1513421..1515775 [+], 235549476012virB4 protein  VirB4
5BH132901515772..1516218 [+], 44749476013hypothetical protein  VirB5
6BH13300 (virB6)1516205..1517170 [+], 96649476014virB protein  VirB6
7BH133101517298..1517708 [+], 41149476015hypothetical protein  VirB7
8BH13320 (virB8)1517698..1518366 [+], 66949476016virB8 protein  VirB8
9BH13330 (virB9)1518366..1519229 [+], 86449476017virB9 protein  VirB9
10BH13340 (virB10)1519222..1520412 [+], 119149476018virB10 protein  VirB10
11BH13350 (virB11)1520381..1521451 [+], 107149476019virB11 protein  VirB11
12BH133601521519..1521725 [+], 20749476020hypothetical protein 
13BH133701521736..1523370 [+], 163549476021cell filamentation protein 
14BH13380 (traG)1523533..1525452 [+], 192049476022conjugal transfer protein TraG  VirD4
15BH133901525994..1527622 [+], 162949476023hypothetical protein 
16BH134001528692..1530290 [+], 159949476024cell filamentation protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes
Crucial for establishment of infection in the primary niche- the endothelial cells, required for colonization of endothelial cells, by mediating the intracellular delivery of effector proteins (BepA-BepG). Translocation of the Beps provokes distinct cellular phenotypes: (i) a massive cytoskeleton rearrangement, resulting in the engulfment of bacterial aggregates (a phenotype called 'invasome' formation), (ii) NF-kappaB-dependent proinflammatory activation, characterized by chemokine secretion and expression of cell adhesion proteins, and (iii) enhanced cell survival as a result of anti-apoptosis (iv) capillary-like sprout formation of endothelial cell aggregates

Effectors
BepA, BepB, BepC, BepD, BepE, BepF, BepG

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1BH13370 1521736..1523370 [+], 163549476021cell filamentation protein  BepA
2BH13390 1525994..1527622 [+], 162949476023hypothetical protein  BepB
3BH13400 1528692..1530290 [+], 159949476024cell filamentation protein  BepC
4BH13410 1530764..1532368 [+], 160549476025hypothetical protein  BepD
5BH13420 1532694..1534088 [+], 139549476026hypothetical protein  BepE
6BH13430 1534424..1536928 [+], 250549476027hypothetical protein  BepF
7BH13440 1537113..1540244 [+], 313249476028hypothetical protein  BepG

Download FASTA format files
Proteins        Genes
(1) Guy L; Nystedt B; Sun Y; Naslund K; Berglund EC; Andersson SG (2012). A genome-wide study of recombination rate variation in Bartonella henselae. BMC Evol Biol. 12(1):65. [PudMed:22577862] in_silico
(2) Truttmann MC; Misselwitz B; Huser S; Hardt WD; Critchley DR; Dehio C (2011). Bartonella henselae engages inside-out and outside-in signaling by integrin beta1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci. 124(Pt 21):3591-602. [PudMed:22045736] experimental
(3) Fernandez-Gonzalez E; de Paz HD; Alperi A; Agundez L; Faustmann M; Sangari FJ; Dehio C; Llosa M (2011). Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. J Bacteriol. 193(22):6257-65. [PudMed:21908662] experimental
(4) Schroder G; Schuelein R; Quebatte M; Dehio C (2011). Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae. Proc Natl Acad Sci U S A. 108(35):14643-8. [PudMed:21844337] experimental
(5) Scheidegger F; Quebatte M; Mistl C; Dehio C (2011). The Bartonella henselae VirB/Bep system interferes with vascular endothelial growth factor (VEGF) signalling in human vascular endothelial cells. Cell Microbiol. 13(3):419-31. [PudMed:21044238] experimental
(6) Truttmann MC; Rhomberg TA; Dehio C (2011). Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells. Cell Microbiol. 13(2):284-99. [PudMed:20964799] experimental
(7) Quebatte M; Dehio M; Tropel D; Basler A; Toller I; Raddatz G; Engel P; Huser S; Schein H; Lindroos HL; Andersson SG; Dehio C (2010). The BatR/BatS two-component regulatory system controls the adaptive response of Bartonella henselae during human endothelial cell infection. J Bacteriol. 192(13):3352-67. [PudMed:20418395] experimental
(8) Scheidegger F; Ellner Y; Guye P; Rhomberg TA; Weber H; Augustin HG; Dehio C (2009). Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cell Microbiol. 11(7):1088-101. [PudMed:19416269] experimental
(9) Schulein R; Guye P; Rhomberg TA; Schmid MC; Schroder G; Vergunst AC; Carena I; Dehio C (2005). A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells. Proc Natl Acad Sci U S A. 102(3):856-61. [PudMed:15642951] experimental
(10) Schmid MC; Schulein R; Dehio M; Denecker G; Carena I; Dehio C (2004). The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. Mol Microbiol. 52(1):81-92. [PudMed:15049812] experimental
(11) Schmiederer M; Arcenas R; Widen R; Valkov N; Anderson B (2001). Intracellular induction of the Bartonella henselae virB operon by human endothelial cells. Infect Immun. 69(10):6495-502. [PudMed:11553594] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation