SecReT4
T4SS ID35
StrainHelicobacter pylori P12
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_011498
Location553525..584777
NameCag
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentCagCCagDCagECagFCagGCagHCagICagLCagN
Number111111111
ComponentCagMCagTCagUCagVCagWCagXCagYCagZCagalpha
Number111111111
ComponentCagbetaCaggammaCagdelta
Number111

The information of T4SS components from NC_011498
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1HPP12_0523 (era)549537..550442 [+], 906210134718GTP-binding protein Era 
2HPP12_0524550439..551431 [+], 993210134719hypothetical protein 
3HPP12_0525551520..552374 [-], 855210134720hypothetical protein 
4HPP12_0526552393..552584 [+], 192210134721hypothetical protein 
5HPP12_0527 (cag1)552705..553052 [+], 348210134722cag pathogenicity island protein Zeta 
6HPP12_0528 (cag2)553160..553525 [+], 366210134723cag pathogenicity island protein Epsilon 
7HPP12_0529 (cag3)553525..554970 [+], 1446210134724cag pathogenicity island protein Delta  Cagdelta
8HPP12_0530 (cag4)554980..555489 [+], 510210134725cag pathogenicity island protein Gamma  Caggamma
9HPP12_0531 (cag5)555963..558209 [-], 2247210134726cag pathogenicity island protein Beta  Cagbeta
10HPP12_0532 (virB11-2)558218..559210 [-], 993210134727cag pathogenicity island protein Alpha  Cagalpha
11HPP12_0533 (cagZ)559215..559814 [-], 600210134728cag pathogenicity island protein Z  CagZ
12HPP12_0534 (cagY)559964..565669 [-], 5706210134729cag pathogenicity island protein Y VirB10-like protein  CagY
13HPP12_0535 (cagX)565684..567252 [-], 1569210134730cag pathogenicity island protein X VirB9-like protein  CagX
14HPP12_0536 (cagW)567305..568912 [-], 1608210134731cag pathogenicity island protein W  CagW
15HPP12_0537 (cagV)568917..569675 [-], 759210134732cag pathogenicity island protein V  CagV
16HPP12_0538 (cagU)570070..570720 [+], 651210134733cag pathogenicity island protein U  CagU
17HPP12_0539 (cagT)570733..571575 [+], 843210134734cag pathogenicity island protein T  CagT
18HPP12_0540 (cagS)571777..572376 [-], 600210134735cag pathogenicity island protein S 
19HPP12_0541 (cagQ)572815..573195 [-], 381210134736cag pathogenicity island protein Q 
20HPP12_0542 (cagR)572903..573205 [+], 303210134737cag pathogenicity island protein R 
21HPP12_0543 (cagP)573621..573974 [-], 354210134738cag pathogenicity island protein P 
22HPP12_0544 (cagM)574409..575539 [+], 1131210134739cag pathogenicity island protein M  CagM
23HPP12_0545 (cagN)575554..576474 [+], 921210134740cag pathogenicity island protein N  CagN
24HPP12_0546 (cagL)576555..577268 [-], 714210134741cag pathogenicity island protein L  CagL
25HPP12_0547 (cagI)577265..578410 [-], 1146210134742cag pathogenicity island protein I  CagI
26HPP12_0548 (cagH)578421..579533 [-], 1113210134743cag pathogenicity island protein H  CagH
27HPP12_0549 (cagG)579550..579978 [-], 429210134744cag pathogenicity island protein G  CagG
28HPP12_0550 (cagF)580037..580843 [-], 807210134745cag pathogenicity island protein F  CagF
29HPP12_0551 (cagE)580845..583796 [-], 2952210134746cag pathogenicity island protein E VirB4-like protein  CagE
30HPP12_0552 (cagD)583805..584428 [-], 624210134747cag pathogenicity island protein D  CagD
31HPP12_0553 (cagC)584430..584777 [-], 348210134748cag pathogenicity island protein C  CagC
32HPP12_0554 (cagB)584923..585150 [-], 228210134749cag pathogenicity island protein B 
33HPP12_0555 (cagA)585581..589225 [+], 3645210134750cytotoxin-associated protein A 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
CagA; Peptidoglycan

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1HPP12_0555 (cagA)585581..589225 [+], 3645210134750cytotoxin-associated protein A  CagA

Download FASTA format files
Proteins        Genes
(1) You Y; He L; Zhang M; Fu J; Gu Y; Zhang B; Tao X; Zhang J (2012). Comparative Genomics of Helicobacter pylori Strains of China Associated with Different Clinical Outcome. PLoS One. 7(6):e38528. [PudMed:22701658] experimental in_silico
(2) Koch M; Mollenkopf HJ; Klemm U; Meyer TF (2012). Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. Proc Natl Acad Sci U S A. 109(19):E1153-62. [PudMed:22509021]
(3) Pham KT; Weiss E; Jimenez Soto LF; Breithaupt U; Haas R; Fischer W (2012). CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL. PLoS One. 7(4):e35341. [PudMed:22493745] experimental
(4) Jimenez-Soto LF; Rohrer S; Jain U; Ertl C; Sewald X; Haas R (2012). Effects of cholesterol on Helicobacter pylori growth and virulence properties in vitro. Helicobacter. 17(2):133-9. [PudMed:22404444] experimental
(5) Backert S; Clyne M; Tegtmeyer N (2011). Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal. 9:28. [PudMed:22044679]
(6) Kumar Pachathundikandi S; Brandt S; Madassery J; Backert S (2011). Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-alpha. PLoS One. 6(5):e19614. [PudMed:21573018] experimental
(7) Schneider S; Carra G; Sahin U; Hoy B; Rieder G; Wessler S (2011). Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells. Infect Immun. 79(6):2362-71. [PudMed:21402757] experimental
(8) Tegtmeyer N; Backert S (2011). Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein. Eur J Cell Biol. 90(11):880-90. [PudMed:21247656]
(9) Fischer W; Windhager L; Rohrer S; Zeiller M; Karnholz A; Hoffmann R; Zimmer R; Haas R (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826] experimental in_silico
(10) Saha A; Backert S; Hammond CE; Gooz M; Smolka AJ (2010). Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology. 139(1):239-48. [PudMed:20303353] experimental
(11) Fehri LF; Rechner C; Janssen S; Mak TN; Holland C; Bartfeld S; Bruggemann H; Meyer TF (2009). Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. Epigenetics. 4(8):577-86. [PudMed:20081355] experimental
(12) Jimenez-Soto LF; Kutter S; Sewald X; Ertl C; Weiss E; Kapp U; Rohde M; Pirch T; Jung K; Retta SF; Terradot L; Fischer W; Haas R (2009). Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog. 5(12):e1000684. [PudMed:19997503] experimental
(13) Brandt S; Wessler S; Hartig R; Backert S (2009). Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: role in AGS epithelial cell scattering and elongation. Cell Motil Cytoskeleton. 66(10):874-92. [PudMed:19437514] experimental
(14) Svensson H; Hansson M; Kilhamn J; Backert S; Quiding-Jarbrink M (2009). Selective upregulation of endothelial E-selectin in response to Helicobacter pylori-induced gastritis. Infect Immun. 77(7):3109-16. [PudMed:19414551] experimental
(15) Hare S; Fischer W; Williams R; Terradot L; Bayliss R; Haas R; Waksman G (2007). Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. EMBO J. 26(23):4926-34. [PudMed:17972918] experimental
(16) Kwok T; Zabler D; Urman S; Rohde M; Hartig R; Wessler S; Misselwitz R; Berger J; Sewald N; Konig W; Backert S (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. Nature. 449(7164):862-6. [PudMed:17943123] experimental
(17) Pattis I; Weiss E; Laugks R; Haas R; Fischer W (2007). The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein. Microbiology. 153(Pt 9):2896-909. [PudMed:17768234] experimental
(18) Poppe M; Feller SM; Romer G; Wessler S (2007). Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene. 26(24):3462-72. [PudMed:17160020] experimental
(19) Garcia JT; Ferracci F; Jackson MW; Joseph SS; Pattis I; Plano LR; Fischer W; Plano GV (2006). Measurement of effector protein injection by type III and type IV secretion systems by using a 13-residue phosphorylatable glycogen synthase kinase tag. Infect Immun. 74(10):5645-57. [PudMed:16988240] experimental
(20) Backert S; Kwok T; Konig W (2005). Conjugative plasmid DNA transfer in Helicobacter pylori mediated by chromosomally encoded relaxase and TraG-like proteins. Microbiology. 151(Pt 11):3493-503. [PudMed:16272373] experimental
(21) Bauer B; Moese S; Bartfeld S; Meyer TF; Selbach M (2005). Analysis of cell type-specific responses mediated by the type IV secretion system of Helicobacter pylori. Infect Immun. 73(8):4643-52. [PudMed:16040977] experimental
(22) Wessler S; Rapp UR; Wiedenmann B; Meyer TF; Schoneberg T; Hocker M; Naumann M (2002). B-Raf/Rap1 signaling, but not c-Raf-1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection. FASEB J. 16(3):417-9. [PudMed:11790728] experimental
(23) Churin Y; Kardalinou E; Meyer TF; Naumann M (2001). Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection. Mol Microbiol. 40(4):815-23. [PudMed:11401689] experimental
(24) Stein M; Rappuoli R; Covacci A; Blanke SR; Ye D; Odenbreit S; Gebert B; Puls J; Fischer W; Haas R (2001). Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and processing of CagA. Cell Microbiol. 3(1):21-31. [PudMed:11207617] experimental
(25) Ramarao N; Gray-Owen SD; Backert S; Meyer TF (2000). Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components. Mol Microbiol. 37(6):1389-404. [PudMed:10998171] experimental
(26) Odenbreit S; Puls J; Sedlmaier B; Gerland E; Fischer W; Haas R (2000). Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science. 287(5457):1497-500. [PudMed:10688800] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation