SecReT4
T4SS ID37
StrainHelicobacter pylori HPAG1
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_008086
Location514158..545246; 1431707..1432237
NameCag
Functioneffector translocation
ClassificationType IVA; Type P
insolico Bioinformatics investigation has been performed on this T4SS.

T4SS components
ComponentCagCCagDCagECagFCagGCagHCagICagLCagN
Number112111111
ComponentCagMCagTCagUCagVCagWCagXCagYCagZCagalpha
Number111111311
ComponentCagbetaCaggammaCagdelta
Number111

The information of T4SS components from NC_008086
Region 1: 514158..545246
Click the image to have a larger view
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1HPAG1_0491 (era)509873..510778 [+], 906108562916GTP-binding protein Era 
2HPAG1_0492510775..511767 [+], 993108562917hypothetical protein 
3HPAG1_0493511846..512700 [-], 855108562918hypothetical protein 
4HPAG1_0494512719..512958 [+], 240108562919IS606 transposase 
5HPAG1_0495513044..513391 [+], 348108562920cag pathogenicity island protein 1 
6HPAG1_0496513407..514165 [+], 759108562921HP0521B-like protein 
7HPAG1_0497514158..515603 [+], 1446108562922cag pathogenicity island protein 3  Cagdelta
8HPAG1_0498515613..516122 [+], 510108562923cag pathogenicity island protein 4  Caggamma
9HPAG1_0499516241..518487 [-], 2247108562924cag pathogenicity island protein 5  Cagbeta
10HPAG1_0500518496..519488 [-], 993108562925cag pathogenicity island encoded protein/ATPase protein  Cagalpha
11HPAG1_0501519493..520092 [-], 600108562926cag pathogenicity island protein Z  CagZ
12HPAG1_0502520227..524114 [-], 3888108562927cag pathogenicity island protein Y  CagY
13HPAG1_0503524173..526161 [-], 1989108562928cag pathogenicity island protein Y  CagY
14HPAG1_0504526176..527747 [-], 1572108562929cag pathogenicity island protein X  CagX
15HPAG1_0505527797..529404 [-], 1608108562930cag pathogenicity island protein W  CagW
16HPAG1_0506529409..530167 [-], 759108562931cag pathogenicity island protein V  CagV
17HPAG1_0507530565..531215 [+], 651108562932cag pathogenicity island protein U  CagU
18HPAG1_0508531228..532070 [+], 843108562933cag pathogenicity island protein T  CagT
19HPAG1_0510532270..532869 [-], 600108562935cag pathogenicity island protein S 
20HPAG1_0511533301..533681 [-], 381108562936cag pathogenicity island protein Q 
21HPAG1_0512534882..536012 [+], 1131108562937cag pathogenicity island protein M  CagM
22HPAG1_0513536027..536947 [+], 921108562938cag pathogenicity island protein N  CagN
23HPAG1_0514537029..537742 [-], 714108562939cag pathogenicity island protein L  CagL
24HPAG1_0515537739..538884 [-], 1146108562940cag pathogenicity island protein I  CagI
25HPAG1_0516538895..540007 [-], 1113108562941cag pathogenicity island protein H  CagH
26HPAG1_0517540024..540452 [-], 429108562942cag pathogenicity island protein G  CagG
27HPAG1_0518540507..541313 [-], 807108562943cag pathogenicity island protein F  CagF
28HPAG1_0519541315..542631 [-], 1317108562944cag pathogenicity island protein E  CagE
29HPAG1_0520542661..544265 [-], 1605108562945cag pathogenicity island protein E  CagE
30HPAG1_0521544274..544924 [-], 651108562946cag pathogenicity island protein D  CagD
31HPAG1_0522544899..545246 [-], 348108562947cag pathogenicity island protein C  CagC
32HPAG1_0523545391..545618 [-], 228108562948cag pathogenicity island protein B 
33HPAG1_0524546049..549651 [+], 3603108562949cytotoxin-associated protein A 
34HPAG1_0525549714..549863 [-], 150108562950transposase B-like protein 
35HPAG1_0526549878..550033 [-], 156108562951transposase B-like protein 
 
Region 2: 1431707..1432237
Click the image to have a larger view
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1HPAG1_1378 (trmE)1427104..1428489 [+], 1386108563803tRNA modification GTPase TrmE 
2HPAG1_13791428703..1430943 [+], 2241108563804outer membrane protein HomD 
3HPAG1_13801431072..1431218 [-], 147108563805hypothetical protein 
4HPAG1_13811431375..1431626 [+], 252108563806MobC-like protein 
5HPAG1_13821431707..1432237 [+], 531108563807cagY like protein  CagY
6HPAG1_1383 (thyX)1432271..1432897 [-], 627108563808FAD-dependent thymidylate synthase 
7HPAG1_13841432919..1434712 [-], 1794108563809glucosamine--fructose-6-phosphate aminotransferase 
8HPAG1_13851434713..1434952 [-], 240108563810hypothetical protein 
9HPAG1_13861434995..1435537 [-], 543108563811purine nucleoside phosphorylase 
10HPAG1_1387 (dnaA)1435690..1437057 [+], 1368108563812chromosomal replication initiation protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
CagA; Peptidoglycan

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1HPAG1_0524 546049..549651 [+], 3603108562949cytotoxin-associated protein A  CagA

Download FASTA format files
Proteins        Genes
(1) You Y; He L; Zhang M; Fu J; Gu Y; Zhang B; Tao X; Zhang J (2012). Comparative Genomics of Helicobacter pylori Strains of China Associated with Different Clinical Outcome. PLoS One. 7(6):e38528. [PudMed:22701658] experimental in_silico
(2) Fischer W; Windhager L; Rohrer S; Zeiller M; Karnholz A; Hoffmann R; Zimmer R; Haas R (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826] experimental in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation