SecReT4
T4SS ID38
StrainHelicobacter pylori J99
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_000921
Location511642..542832
NameCag
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentCagCCagDCagECagFCagGCagHCagICagLCagN
Number111111111
ComponentCagMCagTCagUCagVCagWCagXCagYCagZCagalpha
Number111111111
ComponentCagbetaCaggammaCagdelta
Number111

The information of T4SS components from NC_000921
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1jhp0466 (era)507322..508227 [+], 90615611533GTP-binding protein Era 
2jhp0467508224..509216 [+], 99315611534hypothetical protein 
3jhp0468509304..510155 [-], 85215611535hypothetical protein 
4jhp0469 (orf6)510500..510847 [+], 34815611536cag island protein 
5jhp0470 (orf7)510990..511649 [+], 66015611537cag island protein 
6jhp0471 (orf8)511642..513087 [+], 144615611538cag island protein  Cagdelta
7jhp0472 (orf9)513097..513606 [+], 51015611539cag island protein  Caggamma
8jhp0473 (virD4)514088..516334 [-], 224715611540cag island protein, DNA transfer protein  Cagbeta
9jhp0474 (virB11_1)516343..517335 [-], 99315611541cag island protein, DNA transfer protein  Cagalpha
10jhp0475 (orf12)517340..517939 [-], 60015611542cag island protein  CagZ
11jhp0476 (orf13/14)518074..523533 [-], 546015611543cag island protein  CagY
12jhp0477 (orf15)523548..525116 [-], 156915611544cag island protein  CagX
13jhp0478 (orf16)525169..526776 [-], 160815611545cag island protein  CagW
14jhp0479 (orf17)526781..527539 [-], 75915611546cag island protein  CagV
15jhp0480 (orf18)527921..528577 [+], 65715611547cag island protein  CagU
16jhp0481 (cagT)528613..529455 [+], 84315611548cag island protein  CagT
17jhp0482 (cagS)529660..530259 [-], 60015611549cag island protein 
18jhp0483 (cagQ)530698..531078 [-], 38115611550cag island protein 
19jhp0484 (cagP)531505..531849 [-], 34515611551cag island protein 
20jhp0485 (cagM)532464..533594 [+], 113115611552cag island protein  CagM
21jhp0486 (cagN)533609..534529 [+], 92115611553cag island protein  CagN
22jhp0487 (cagL)534611..535324 [-], 71415611554cag island protein  CagL
23jhp0488 (cagI)535321..536466 [-], 114615611555cag island protein  CagI
24jhp0489 (cagH)536477..537589 [-], 111315611556cag island protein  CagH
25jhp0490 (cagG)537606..538034 [-], 42915611557cag island protein  CagG
26jhp0491 (cagF)538089..538895 [-], 80715611558cag island protein  CagF
27jhp0492 (cagE)538897..541848 [-], 295215611559DNA transfer protein  CagE
28jhp0493 (cagD)541857..542483 [-], 62715611560cag island protein  CagD
29jhp0494 (cagC)542485..542832 [-], 34815611561cag island protein  CagC
30jhp0495 (cagA)543605..547108 [+], 350415611562cag island protein, cytotoxicity associated immunodominant antigen 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
CagA; Peptidoglycan

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1jhp0495 (cagA)543605..547108 [+], 350415611562cag island protein, cytotoxicity associated immunodominant antigen  CagA

Download FASTA format files
Proteins        Genes
(1) You Y; He L; Zhang M; Fu J; Gu Y; Zhang B; Tao X; Zhang J (2012). Comparative Genomics of Helicobacter pylori Strains of China Associated with Different Clinical Outcome. PLoS One. 7(6):e38528. [PudMed:22701658] experimental in_silico
(2) Rizzato C; Torres J; Plummer M; Munoz N; Franceschi S; Camorlinga-Ponce M; Fuentes-Panana EM; Canzian F; Kato I (2012). Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention. PLoS One. 7(1):e29605. [PudMed:22235308] experimental in_silico
(3) Tegtmeyer N; Backert S (2011). Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein. Eur J Cell Biol. 90(11):880-90. [PudMed:21247656]
(4) Fischer W; Windhager L; Rohrer S; Zeiller M; Karnholz A; Hoffmann R; Zimmer R; Haas R (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826] experimental in_silico
(5) Aras RA; Fischer W; Perez-Perez GI; Crosatti M; Ando T; Haas R; Blaser MJ (2003). Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component. J Exp Med. 198(9):1349-60. [PudMed:14581606] experimental
(6) Backert S; Churin Y; Meyer TF (2002). Helicobacter pylori type IV secretion, host cell signalling and vaccine development. Keio J Med. 51 Suppl 2:6-14. [PudMed:12528929] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation