SecReT4
T4SS ID386
StrainBordetella pertussis Tohama I
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_002929
Location3991435..3999743
NamePtl
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentPtlAPtlBPtlCPtlDPtlIPtlEPtlFPtlGPtlH
Number111111111

The information of T4SS components from NC_002929
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1BP37823987011..3987991 [+], 98133594637hypothetical protein 
2BP3783 (ptxA)3988258..3989067 [+], 81033594638toxin subunit 1 
3BP3784 (ptxB)3989107..3989787 [+], 68133594639toxin subunit 2 
4BP3785 (ptxD)3989781..3990239 [+], 45933594640toxin subunit 4 
5BP3786 (ptxE)3990212..3990613 [+], 40233594641toxin subunit 5 
6BP3787 (ptxC)3990696..3991379 [+], 68433594642toxin subunit 3 
7BP3788 (ptlA)3991435..3991743 [+], 30933594643toxin transport protein  PtlA
8BP3789 (ptlB)3991762..3992076 [+], 31533594644toxin transport protein  PtlB
9BP37903992073..3994547 [+], 247533594645secretion system protein  PtlC
10BP37913994555..3995946 [+], 139233594646hypothetical protein  PtlD
11BP37923995943..3996128 [+], 18633594647secretion system protein  PtlI
12BP37933996107..3996808 [+], 70233594648secretion system protein  PtlE
13BP37943996805..3997626 [+], 82233594649secretion system protein  PtlF
14BP37953997607..3998731 [+], 112533594650secretion system protein  PtlG
15BP37963998724..3999743 [+], 102033594651secretion system protein  PtlH
16BP37973999949..4000839 [-], 89133594652hypothetical protein 
17BP37984000982..4001875 [+], 89433594653AraC family transcriptional regulator 
18BP37994001958..4002332 [+], 37533594654hypothetical protein 
19BP38004002310..4003719 [+], 141033594655hypothetical protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
PtxA, PtxB, PtxD, PtxE, PtxC

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1BP3783 (ptxA)3988258..3989067 [+], 81033594638toxin subunit 1  PtxA
2BP3784 (ptxB)3989107..3989787 [+], 68133594639toxin subunit 2  PtxB
3BP3785 (ptxD)3989781..3990239 [+], 45933594640toxin subunit 4  PtxD
4BP3786 (ptxE)3990212..3990613 [+], 40233594641toxin subunit 5  PtxE
5BP3787 (ptxC)3990696..3991379 [+], 68433594642toxin subunit 3  PtxC

Download FASTA format files
Proteins        Genes
(1) Verma A; Cheung AM; Burns DL (2008). Stabilization of the pertussis toxin secretion apparatus by the C terminus of PtlD. J Bacteriol. 190(21):7285-90. [PudMed:18723610] experimental
(2) Rambow-Larsen AA; Weiss AA (2004). Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. J Bacteriol. 186(1):43-50. [PudMed:14679223] experimental
(3) Parkhill J; Sebaihia M; Preston A; Murphy LD; Thomson N; Harris DE; Holden MT; Churcher CM; Bentley SD; Mungall KL; Cerdeno-Tarraga AM; Temple L; James K; Harris B; Quail MA; Achtman M; Atkin R; Baker S; Basham D; Bason N; Cherevach I; Chillingworth T; Collins M; Cronin A; Davis P; Doggett J; Feltwell T; Goble A; Hamlin N; Hauser H; Holroyd S; Jagels K; Leather S; Moule S; Norberczak H; O'Neil S; Ormond D; Price C; Rabbinowitsch E; Rutter S; Sanders M; Saunders D; Seeger K; Sharp S; Simmonds M; Skelton J; Squares R; Squares S; Stevens K; Unwin L; Whitehead S; Barrell BG; Maskell DJ (2003). Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 35(1):32-40. [PudMed:12910271]
(4) Rambow-Larsen AA; Weiss AA (2002). The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion. J Bacteriol. 184(11):2863-9. [PudMed:12003925] experimental
 
experimental This literature contains experimental investigation