SecReT4
T4SS ID39
StrainHelicobacter pylori G27
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_011333
Location514715..547464
NameCag
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentCagCCagDCagECagFCagGCagHCagICagLCagN
Number111111111
ComponentCagMCagTCagUCagVCagWCagXCagYCagZCagalpha
Number111111011
ComponentCagbetaCaggammaCagdelta
Number111

The information of T4SS components from NC_011333
Click the image to have a larger view
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1HPG27_476 (era)510908..511813 [+], 906208434439GTP-binding protein Era 
2HPG27_477511810..512802 [+], 993208434440hypothetical protein 
3HPG27_478512885..513766 [-], 882208434441hypothetical protein 
4HPG27_479 (cag1)513910..514257 [+], 348208434442cag pathogenicity island protein 1 
5HPG27_480514464..514715 [+], 252208434443hypothetical protein 
6HPG27_481 (cag3)514715..516160 [+], 1446208434444cag pathogenicity island protein 3  Cagdelta
7HPG27_482 (cag4)516165..516674 [+], 510208434445cag pathogenicity island protein 4  Caggamma
8HPG27_483 (cag5)516793..519039 [-], 2247208434446cag pathogenicity island protein 5  Cagbeta
9HPG27_484519048..520040 [-], 993208434447virB11-like cag pathogenicity islandencoded protein / ATPase  Cagalpha
10HPG27_485 (cagZ)520045..520644 [-], 600208434448cag pathogenicity island protein Z  CagZ
11HPG27_487 (cagX)526506..528071 [-], 1566208434449cag pathogenicity island protein X  CagX
12HPG27_488 (cagW)528123..529730 [-], 1608208434450cag pathogenicity island protein W  CagW
13HPG27_489 (cagV)529735..530493 [-], 759208434451cag pathogenicity island protein V  CagV
14HPG27_490 (cagU)530890..531540 [+], 651208434452cag pathogenicity island protein U  CagU
15HPG27_491 (cagT)531553..532395 [+], 843208434453cag pathogenicity island protein T  CagT
16HPG27_492 (cagS)532592..533191 [-], 600208434454cag pathogenicity island protein S 
17HPG27_493 (cagQ)535518..535823 [-], 306208434455cag pathogenicity island protein Q 
18HPG27_494535835..536014 [-], 180208434456hypothetical protein 
19HPG27_495 (cagM)537100..538230 [+], 1131208434457cag pathogenicity island protein M  CagM
20HPG27_496 (cagN)538245..539165 [+], 921208434458cag pathogenicity island protein N  CagN
21HPG27_497 (cagL)539247..539960 [-], 714208434459cag pathogenicity island protein L  CagL
22HPG27_498 (cagI)539957..541033 [-], 1077208434460cag pathogenicity island protein I  CagI
23HPG27_499 (cagH)541113..542045 [-], 933208434462cag pathogenicity island protein H  CagH
24HPG27_500542044..542244 [+], 201208434461hypothetical protein 
25HPG27_501 (cagG)542241..542669 [-], 429208434463cag pathogenicity island protein G  CagG
26HPG27_502 (cagF)542724..543530 [-], 807208434464cag pathogenicity island protein F  CagF
27HPG27_503 (cagE)543532..546483 [-], 2952208434465cag pathogenicity island protein E  CagE
28HPG27_504 (cagD)546492..547115 [-], 624208434466cag pathogenicity island protein D  CagD
29HPG27_505 (cagC)547117..547464 [-], 348208434467cag pathogenicity island protein C  CagC
30HPG27_506 (cagB)547609..547836 [-], 228208434468cag pathogenicity island protein B 
31HPG27_507 (cagA)548263..551955 [+], 3693208434469cytotoxin-associated protein A 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
CagA; Peptidoglycan

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1HPG27_507 (cagA)548263..551955 [+], 3693208434469cytotoxin-associated protein A  CagA

Download FASTA format files
Proteins        Genes
(1) You Y; He L; Zhang M; Fu J; Gu Y; Zhang B; Tao X; Zhang J (2012). Comparative Genomics of Helicobacter pylori Strains of China Associated with Different Clinical Outcome. PLoS One. 7(6):e38528. [PudMed:22701658] experimental in_silico
(2) Rizzato C; Torres J; Plummer M; Munoz N; Franceschi S; Camorlinga-Ponce M; Fuentes-Panana EM; Canzian F; Kato I (2012). Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention. PLoS One. 7(1):e29605. [PudMed:22235308] experimental in_silico
(3) Tegtmeyer N; Backert S (2011). Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein. Eur J Cell Biol. 90(11):880-90. [PudMed:21247656]
(4) Fischer W; Windhager L; Rohrer S; Zeiller M; Karnholz A; Hoffmann R; Zimmer R; Haas R (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826] experimental in_silico
(5) Fehri LF; Rechner C; Janssen S; Mak TN; Holland C; Bartfeld S; Bruggemann H; Meyer TF (2009). Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation. Epigenetics. 4(8):577-86. [PudMed:20081355] experimental
(6) Allison CC; Kufer TA; Kremmer E; Kaparakis M; Ferrero RL (2009). Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol. 183(12):8099-109. [PudMed:20007577] experimental
(7) Pinto-Santini DM; Salama NR (2009). Cag3 is a novel essential component of the Helicobacter pylori Cag type IV secretion system outer membrane subcomplex. J Bacteriol. 191(23):7343-52. [PudMed:19801411] experimental
(8) Cendron L; Couturier M; Angelini A; Barison N; Stein M; Zanotti G (2009). The Helicobacter pylori CagD (HP0545, Cag24) protein is essential for CagA translocation and maximal induction of interleukin-8 secretion. J Mol Biol. 386(1):204-17. [PudMed:19109970] experimental
(9) Couturier MR; Stein M (2008). Helicobacter pylori produces unique filaments upon host contact in vitro. Can J Microbiol. 54(7):537-48. [PudMed:18641700] experimental
(10) Hilleringmann M; Pansegrau W; Doyle M; Kaufman S; MacKichan ML; Gianfaldoni C; Ruggiero P; Covacci A (2006). Inhibitors of Helicobacter pylori ATPase Cagalpha block CagA transport and cag virulence. Microbiology. 152(Pt 10):2919-30. [PudMed:17005973] experimental
(11) Bourzac KM; Satkamp LA; Guillemin K (2006). The Helicobacter pylori cag pathogenicity island protein CagN is a bacterial membrane-associated protein that is processed at its C terminus. Infect Immun. 74(5):2537-43. [PudMed:16622188] experimental
(12) Couturier MR; Tasca E; Montecucco C; Stein M (2006). Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion system. Infect Immun. 74(1):273-81. [PudMed:16368981] experimental
(13) Backert S; Kwok T; Konig W (2005). Conjugative plasmid DNA transfer in Helicobacter pylori mediated by chromosomally encoded relaxase and TraG-like proteins. Microbiology. 151(Pt 11):3493-503. [PudMed:16272373] experimental
(14) Guillemin K; Salama NR; Tompkins LS; Falkow S (2002). Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc Natl Acad Sci U S A. 99(23):15136-41. [PudMed:12411577] experimental
(15) Ramarao N; Gray-Owen SD; Backert S; Meyer TF (2000). Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components. Mol Microbiol. 37(6):1389-404. [PudMed:10998171] experimental
(16) Stein M; Rappuoli R; Covacci A (2000). Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A. 97(3):1263-8. [PudMed:10655519] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation