SecReT4
T4SS ID44
StrainLegionella longbeachae NSW150
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_013861
Location13014..13409; 402723..413318; 440995..441615; 1248304..1248705; 3252131..3270829; 3570476..3574182; 3625689..3626090
NameDot/Icm
Functioneffector translocation
ClassificationType IVB; Type I
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentDotADotBDotCDotDIcmBIcmCIcmDIcmEIcmF
Number111111411
ComponentIcmGIcmHIcmJIcmKIcmLIcmMIcmNIcmOIcmP
Number111111111
ComponentIcmQIcmRIcmSIcmTIcmVIcmWIcmXLvgA
Number10111111

The information of T4SS components from NC_013861
Region 1: 13014..13409
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_00068434..9138 [+], 705289163359hypothetical protein 
2LLO_00079546..10628 [+], 1083289163360amidase 
3LLO_000810644..11045 [+], 402289163361hypothetical protein 
4LLO_000911039..11245 [+], 207289163362hypothetical protein 
5LLO_001011348..12664 [+], 1317289163363hypothetical protein 
6LLO_0011 (icmD)13014..13409 [+], 396289163364IcmD (DotP)  IcmD
7LLO_001213703..14728 [-], 1026289163365peptidylarginine deiminase 
8LLO_0013 (speA)14730..16628 [-], 1899289163366arginine decarboxylase 
9LLO_001416650..17495 [-], 846289163367carbon-nitrogen hydrolase 
 
Region 2: 402723..413318
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_0357398052..398246 [+], 195289163701hypothetical protein 
2LLO_0358398255..398425 [-], 171289163702hypothetical protein 
3LLO_0359398560..399582 [+], 1023289163703glycosyltransferase 
4LLO_0360399744..402269 [-], 2526289163704cation transport ATPase 
5LLO_0361 (icmX)402723..404117 [-], 1395289163705Intracellular multiplication protein IcmX  IcmX
6LLO_0362 (icmW)404118..404573 [-], 456289163706Intracellular multiplication protein IcmW  IcmW
7LLO_0363 (icmV)404668..405126 [+], 459289163707intracellular multiplication protein IcmV  IcmV
8LLO_0364 (dotA)405123..408266 [+], 3144289163708defect in organelle trafficking protein DotA  DotA
9LLO_0365408286..409626 [+], 1341289163709hypothetical protein 
10LLO_0366409808..410662 [-], 8552891637104-hydroxy-2-oxovalerate aldolase 
11LLO_0367 (dotB)410780..411910 [-], 1131289163711defect in organelle trafficking protein DotB (ATPase)  DotB
12LLO_0368 (dotC)411920..412846 [-], 927289163712defect in organelle trafficking lipoprotein DotC  DotC
13LLO_0369 (dotD)412827..413318 [-], 492289163713lipoprotein DotD  DotD
14LLO_0370 (yhhF)413487..414032 [-], 546289163714methyltransferase 
15LLO_0371414029..415333 [-], 1305289163715zinc protease 
16LLO_0372415330..416652 [-], 1323289163716zinc protease 
17LLO_0373 (ftsY)416714..417766 [+], 1053289163717cell division protein FtsY homolog 
 
Region 3: 440995..441615
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_0387436208..436867 [+], 660289163731hypothetical protein 
2LLO_0388436867..437967 [+], 1101289163732ATPase 
3LLO_0389 (feoA)438180..438410 [+], 231289163733ferrous iron transporter A 
4LLO_0390 (feoB)438407..440659 [+], 2253289163734ferrous iron transport protein B 
5LLO_0391440640..440855 [+], 216289163735hypothetical protein 
6LLO_0392 (lvgA)440995..441615 [+], 621289163736virulence protein LvgA  LvgA
7LLO_0393 (sdhC)441946..442320 [+], 375289163737succinate dehydrogenase, cytochrome b556 subunit 
8LLO_0394 (sdhD)442314..442661 [+], 348289163738succinate dehydrogenase, hydrophobic membrane anchor protein 
9LLO_0395 (sdhA)442663..444432 [+], 1770289163739succinate dehydrogenase flavoprotein subunit 
10LLO_0396 (sdhB)444447..445169 [+], 723289163740succinate dehydrogenase, iron sulfur protein 
 
Region 4: 1248304..1248705
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_10561243551..1244339 [+], 789289164397hypothetical protein 
2LLO_1057 (glyQ)1244441..1245352 [+], 912289164398glycyl-tRNA synthetase subunit alpha 
3LLO_1058 (glyS)1245342..1247411 [+], 2070289164399glycyl-tRNA synthetase beta chain 
4LLO_10591247408..1248151 [+], 744289164400hypothetical protein 
5LLO_1060 (icmD)1248304..1248705 [-], 402289164401IcmD (DotP)  IcmD
6LLO_1061 (uhpC)1249188..1250558 [-], 1371289164402membrane protein regulates uhpT expression 
7LLO_10621250742..1252409 [+], 1668289164403hypothetical protein 
8LLO_10631252487..1252915 [-], 429289164404hypothetical protein 
9LLO_1064a1252991..1253431 [-], 441289164405hypothetical protein 
10LLO_10651253440..1253643 [-], 204289164406hypothetical protein 
 
Region 5: 3252131..3270829
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_40763247194..3247493 [-], 300289166098hypothetical protein 
2LLO_27733247441..3247887 [-], 447289166099hypothetical protein 
3LLO_27743248183..3248692 [-], 510289166100hypothetical protein 
4LLO_27753248768..3248890 [-], 123289166101hypothetical protein 
5LLO_27763248932..3249129 [-], 198289166102hypothetical protein 
6LLO_27773249484..3249930 [-], 447289166103hypothetical protein 
7LLO_2778 (ompR)3250145..3250873 [+], 729289166104DNA-binding response regulator in two-component regulatory system with EnvZ 
8LLO_27793250870..3252138 [+], 1269289166105sensor histidine kinase 
9LLO_2780 (dotO)3252131..3255160 [-], 3030289166106hypothetical protein  IcmB
10LLO_2781 (dotN)3255175..3255801 [-], 627289166107hypothetical protein  IcmJ
11LLO_2782 (dotP)3255926..3256327 [-], 402289166108hypothetical protein  IcmD
12LLO_2783 (dotE)3256374..3256952 [-], 579289166109hypothetical protein  IcmC
13LLO_2784 (dotF)3256961..3257794 [-], 834289166110Component of the Dot/Icm secretion system  IcmG
14LLO_2785 (dotG)3257807..3262384 [-], 4578289166111IcmE/DotG protein  IcmE
15LLO_2786 (icmK)3262385..3263503 [-], 1119289166112hypothetical protein  IcmK
16LLO_2787 (dotI)3263503..3264141 [-], 639289166113hypothetical protein  IcmL
17LLO_2788 (dotJ)3264160..3264444 [-], 285289166114Component of the Dot/Icm secretion system. inner membrane protein  IcmM
18LLO_2789 (lphA)3264453..3264956 [-], 504289166115hypothetical protein  IcmN
19LLO_2790 (dotL)3265503..3267851 [-], 2349289166116hypothetical protein  IcmO
20LLO_2791 (dotM)3267848..3268981 [-], 1134289166117hypothetical protein  IcmP
21LLO_2792 (icmQ)3269101..3269676 [-], 576289166118hypothetical protein  IcmQ
22LLO_2793 (ligB)3269819..3270085 [-], 267289166119LigB protein (part of the Dot/Icm secretion system) 
23LLO_2794 (icmS)3270218..3270562 [-], 345289166120hypothetical protein  IcmS
24LLO_2795 (icmT)3270569..3270829 [-], 261289166121hypothetical protein  IcmT
25LLO_27963271083..3271301 [-], 219289166122hypothetical protein 
26LLO_2797 (cspD)3271701..3271931 [+], 231289166123Cold shock-like protein CspD 
27LLO_2798 (hemH)3272059..3273096 [+], 1038289166124ferrochelatase 
28LLO_27993273074..3274114 [+], 1041289166125efflux protein 
 
Region 6: 3570476..3574182
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_3070 (sufD)3565793..3567073 [-], 1281289166382component of SufBCD complex 
2LLO_3071 (sufC)3567073..3567822 [-], 750289166383component of SufBCD complex, ATP-binding component of ABC superfamily 
3LLO_3072 (sufB)3567824..3569272 [-], 1449289166384component of SufBCD complex 
4LLO_30733569265..3569726 [-], 462289166385hypothetical protein 
5LLO_40853569985..3570143 [-], 159289166386hypothetical protein 
6LLO_3074 (dotU)3570476..3571261 [+], 786289166387hypothetical protein  IcmH
7LLO_3075 (icmF)3571261..3574182 [+], 2922289166388hypothetical protein  IcmF
8LLO_30763574364..3575185 [+], 822289166389hypothetical protein 
9LLO_30773575264..3576199 [-], 936289166390hypothetical protein 
10LLO_30813577745..3578905 [-], 1161289166391patatin-like phospholipase 
 
Region 7: 3625689..3626090
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1LLO_31033621031..3621708 [-], 678289166413amidase 
2LLO_31043621710..3622780 [-], 1071289166414hypothetical protein 
3LLO_31053623704..3624300 [+], 597289166415hypothetical protein 
4LLO_31063624347..3625240 [-], 894289166416LysR family transcriptional regulator 
5LLO_3107 (icmD)3625689..3626090 [+], 402289166417IcmD (DotP)  IcmD
6LLO_31083626234..3627469 [-], 1236289166418FAD dependent oxidoreductase 
7LLO_3110 (lon)3628284..3630686 [+], 2403289166419DNA-binding ATP-dependent protease La 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes

Effectors
LLO_0047, LLO_0081, LLO_0192, LLO_0197, LLO_0200, LLO_0214, MavN, Lem29, LLO_0308, LegG2, AnkD/legA15, SidE/laiD, LLO_0464, LLO_0525, SdhA, LirA, AnkK/legA5, AnkH/legA3, ankW, Ceg33, Lem23, LLO_0783, LLO_0791, RavH, LLO_0934, MarB, Ceg23, RavR, Lem14, LLO_1062, LLO_1240, Ceg19, Ceg4, LLO_1348, RavC, RavT, RalF, LLO_1414, LLO_1437, LpnE, LLO_1503, LLO_1576, Ceg8, Lem25, LegK1, LLO_1691, LLO_1697, YlfA/legC7, VpdC, LLO_1991, Lem23, LegK3, LLO_2220, Lem24, Lem27, LLO_2267, LLO_2314, LLO_2315, LLO_2362, RavS, Lem19, LLO_2404, SdhB, LLO_2453, RavQ, Ceg7, RavZ, SidI/ceg32, LLO_2526, LLO_2530, RavF, LLO_2574, LegA7/ceg11, LLO_2611, LegS1, MavV, AnkC/legA12, LegY, LLO_2845, MavF, LLO_2856, Ceg15, RavL, SdeB, SidJ, SdeD, SdcA, RavN, PieE, LLO_3206, LLO_3208, LegD2, RavK, LLO_3270, VipF, LnaB, LLO_3405, LLO_3444

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1LLO_0047 54872..55351 [+], 480289163393hypothetical protein  LLO_0047
2LLO_0081 (rsmE)88710..89438 [+], 72928916342616S rRNA methyltransferase  LLO_0081
3LLO_0192 208236..209978 [-], 1743289163536hypothetical protein  LLO_0192
4LLO_0197 214273..214971 [-], 699289163541hypothetical protein  LLO_0197
5LLO_0200 217874..220030 [+], 2157289163544hypothetical protein  LLO_0200
6LLO_0214 235248..236882 [+], 1635289163558hypothetical protein  LLO_0214
7LLO_0254 283828..285765 [-], 1938289163598hypothetical protein  MavN
8LLO_0267 302136..303368 [+], 1233289163611coiled-coil protein  Lem29
9LLO_0308 349856..351772 [+], 1917289163652hypothetical protein  LLO_0308
10LLO_0327 370108..371544 [+], 1437289163671hypothetical protein  LegG2
11LLO_0365 408286..409626 [+], 1341289163709hypothetical protein  AnkD/legA15
12LLO_0425 (sidE)479647..484353 [-], 4707289163769SidE protein  SidE/laiD
13LLO_0464 531463..532284 [+], 822289163808hypothetical protein  LLO_0464
14LLO_0525 589320..591584 [-], 2265289163869hypothetical protein  LLO_0525
15LLO_0548 619308..624842 [-], 5535289163893hypothetical protein  SdhA
16LLO_0565 641312..642103 [-], 792289163910hypothetical protein  LirA
17LLO_0570 (AnkK)646781..648697 [+], 1917289163915substrate of the Dot/Icm secretion system  AnkK/legA5
18LLO_0584 (AnkH)663072..664475 [+], 1404289163929substrate of the Dot/Icm secretion system  AnkH/legA3, ankW
19LLO_0626 709334..709828 [-], 495289163974hypothetical protein  Ceg33
20LLO_0719 813395..813814 [-], 420289164063hypothetical protein  Lem23
21LLO_0783 896082..897350 [+], 1269289164127hypothetical protein  LLO_0783
22LLO_0791 904332..905423 [-], 1092289164135hypothetical protein  LLO_0791
23LLO_0831 956109..957518 [+], 1410289164175hypothetical protein  RavH
24LLO_0934 1073597..1074868 [-], 1272289164280hypothetical protein  LLO_0934
25LLO_0991 1165097..1166263 [-], 1167289164333RhoGAP domain protein (GTPase activator of small GTPases)  MarB
26LLO_1014 1196214..1197536 [+], 1323289164355hypothetical protein  Ceg23
27LLO_1034 1216112..1218169 [-], 2058289164375hypothetical protein  RavR
28LLO_1047 1234526..1235239 [+], 714289164388hypothetical protein  Lem14
29LLO_1062 1250742..1252409 [+], 1668289164403hypothetical protein  LLO_1062
30LLO_1240 1467356..1469098 [+], 1743289164582hypothetical protein  LLO_1240
31LLO_1321 1567575..1568333 [-], 759289164662coiled-coil protein  Ceg19
32LLO_1322 1568523..1569617 [+], 1095289164663hypothetical protein  Ceg4
33LLO_1348 1599530..1599946 [+], 417289164688hypothetical protein  LLO_1348
34LLO_1378 1638795..1639553 [+], 759289164714ABC transporter permease  RavC
35LLO_1389 1650275..1651243 [-], 969289164725hypothetical protein  RavT
36LLO_1397 (ralF)1661758..1662912 [-], 1155289164734RalF protein, translocated into host cells by the Dot/Icm system  RalF
37LLO_1414 1684126..1685376 [-], 1251289164751hypothetical protein  LLO_1414
38LLO_1437 1709682..1710164 [-], 483289164770hypothetical protein  LLO_1437
39LLO_1443 1718192..1719322 [+], 1131289164776Sel1 repeat protein  LpnE
40LLO_1503 1777551..1777958 [+], 408289164837hypothetical protein  LLO_1503
41LLO_1576 1856728..1858197 [+], 1470289164909hypothetical protein  LLO_1576
42LLO_1601 1883980..1884687 [-], 708289164934hypothetical protein  Ceg8
43LLO_1650 1946940..1949318 [-], 2379289164985hypothetical protein  Lem25
44LLO_1682 1990167..1991777 [-], 1611289165017serine/threonine-protein kinase  LegK1
45LLO_1691 2002166..2003284 [-], 1119289165026hypothetical protein  LLO_1691
46LLO_1697 2007806..2008450 [+], 645289165032hypothetical protein  LLO_1697
47LLO_1707 2023159..2024508 [+], 1350289165043hypothetical protein  YlfA/legC7
48LLO_1791 2113158..2115797 [-], 2640289165127phospholipase, patatin family  VpdC
49LLO_1991 2340619..2341269 [-], 651289165322hypothetical protein  LLO_1991
50LLO_2172 2525179..2526210 [-], 1032289165501hypothetical protein  Lem23
51LLO_2218 2586120..2587508 [-], 1389289165547Ser/Thr protein kinase  LegK3
52LLO_2220 2588642..2589484 [+], 843289165549hypothetical protein  LLO_2220
53LLO_2227 2600230..2601054 [+], 825289165556hypothetical protein  Lem24
54LLO_2238 2614233..2615978 [-], 1746289165566hypothetical protein  Lem27
55LLO_2267 2655833..2657560 [+], 1728289165596hypothetical protein  LLO_2267
56LLO_2314 2713233..2714498 [-], 1266289165639hypothetical protein  LLO_2314
57LLO_2315 2714511..2715110 [-], 600289165640hypothetical protein  LLO_2315
58LLO_2362 2773400..2774410 [-], 1011289165683hemolysin D  LLO_2362
59LLO_2390 2801721..2803571 [+], 1851289165712hypothetical protein  RavS
60LLO_2398 2814159..2815355 [+], 1197289165722hypothetical protein  Lem19
61LLO_2404 2821719..2822663 [+], 945289165728hypothetical protein  LLO_2404
62LLO_2439 2859351..2865380 [+], 6030289165760hypothetical protein  SdhB
63LLO_2453 2878887..2879798 [-], 912289165774hypothetical protein  LLO_2453
64LLO_2487 2916468..2917550 [+], 1083289165808hypothetical protein  RavQ
65LLO_2491 2922600..2923718 [+], 1119289165812hypothetical protein  Ceg7
66LLO_2508 2943541..2945004 [+], 1464289165829hypothetical protein  RavZ
67LLO_2525 2963576..2966407 [+], 2832289165845hypothetical protein  SidI/ceg32
68LLO_2526 2966409..2967296 [+], 888289165846hypothetical protein  LLO_2526
69LLO_2530 2972059..2972691 [+], 633289165850hypothetical protein  LLO_2530
70LLO_2549 2993661..2994911 [+], 1251289165869coiled-coil protein  RavF
71LLO_2574 3020668..3022038 [+], 1371289165895hypothetical protein  LLO_2574
72LLO_2582 3030213..3030851 [-], 639289165903hypothetical protein  LegA7/ceg11
73LLO_2611 3063901..3064899 [+], 999289165935hypothetical protein  LLO_2611
74LLO_2622 3076104..3077255 [+], 1152289165946sphingomyelin phosphodiesterase  LegS1
75LLO_2645 3109641..3110990 [-], 1350289165971hypothetical protein  MavV
76LLO_2705 3177790..3179187 [-], 1398289166029ankyrin repeat protein  AnkC/legA12
77LLO_2801 3277307..3278602 [+], 1296289166127glucan 1,4-alpha-glucosidase  LegY
78LLO_2845 3319949..3320566 [+], 618289166172coiled-coil protein  LLO_2845
79LLO_2850 3325266..3326108 [+], 843289166177hypothetical protein  MavF
80LLO_2856 (lporfX)3331160..3331603 [+], 444289166183hypothetical protein  LLO_2856
81LLO_2983 3463204..3463950 [+], 747289166302hypothetical protein  Ceg15
82LLO_3030 3527027..3527863 [+], 837289166345hypothetical protein  RavL
83LLO_3095 3603931..3608421 [+], 4491289166405Similar to Sid proteins  SdeB
84LLO_3096 3608613..3611210 [-], 2598289166406hypothetical protein  SidJ
85LLO_3097 (laiE)3611262..3612452 [-], 1191289166407SdeA protein  SdeD
86LLO_3098 (sidC)3612748..3615657 [+], 2910289166408SidC protein  SdcA
87LLO_3126 3652732..3653364 [-], 633289166435hypothetical protein  RavN
88LLO_3131 (pieE)3659094..3660842 [+], 1749289166440substrate of the Dot/Icm secretion system  PieE
89LLO_3206 3761862..3762461 [+], 600289166518hypothetical protein  LLO_3206
90LLO_3208 3764998..3765846 [+], 849289166520hypothetical protein  LLO_3208
91LLO_3224 3783569..3784501 [-], 933289166536hypothetical protein  LegD2
92LLO_3265 3832683..3833351 [+], 669289166571hypothetical protein  RavK
93LLO_3270 3836767..3839244 [-], 2478289166576hypothetical protein  LLO_3270
94LLO_3312 (vipF)3886622..3887533 [+], 912289166618N-terminal GNAT family acetyltransferase  VipF
95LLO_3335 3913926..3915536 [+], 1611289166641hypothetical protein  LnaB
96LLO_3405 4006539..4009151 [-], 2613289166710hypothetical protein  LLO_3405
97LLO_3444 4069521..4071068 [-], 1548289166749hypothetical protein  LLO_3444

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Proteins        Genes
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Cazalet C; Gomez-Valero L; Rusniok C; Lomma M; Dervins-Ravault D; Newton HJ; Sansom FM; Jarraud S; Zidane N; Ma L; Bouchier C; Etienne J; Hartland EL; Buchrieser C (2010). Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease. PLoS Genet. 6(2):e1000851. [PudMed:20174605] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation