T4SS ID500
StrainWolbachia endosymbiont strain TRS of Brugia malayi
Repliconchromosome [Browse all T4SS(s) in this replicon]
Location365277..371319; 772818..773606; 986653..989007; 1051828..1066132
ClassificationType IVA; Type P
sequence This T4SS has been mentioned in a genome sequencing report.

T4SS components

The information of T4SS components from NC_006833
Region 1: 365277..371319
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0276 (dnaA)361157..362539 [+], 138358584534chromosome replication initiator DnaA 
2Wbm0277362563..363813 [-], 125158584535calcineurin-like phosphoesterase 
3Wbm0278364122..365204 [+], 108358584536GTP cyclohydrolase II 
4Wbm0279365277..365960 [+], 68458584537Type IV secretory pathway, component VirB8  VirB8
5Wbm0280365947..366753 [+], 80758584538Type IV secretory pathway, component VirB9  VirB9
6Wbm0281366770..368266 [+], 149758584539Type IV secretory pathway, VirB10 component  VirB10
7Wbm0282368268..369275 [+], 100858584540type IV secretion system ATPase VirB11  VirB11
8Wbm0283369289..371319 [+], 203158584541type IV secretion system component VirD4  VirD4
9Wbm0284371438..372283 [+], 84658584542Outer surface protein Wsp 
10Wbm0285372470..373405 [-], 93658584543methylase of polypeptide chain release factor 
Region 2: 772818..773606
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0590768732..769190 [-], 45958584847hypothetical protein 
2Wbm0591772818..773606 [+], 78958584848Type IV secretory pathway, VirB9 component  VirB9
3Wbm0592773630..775135 [-], 150658584849monovalent cation/H+ antiporter subunit D 
4Wbm0593775225..776415 [-], 119158584850queuine/archaeosine tRNA-ribosyltransferase 
5Wbm0594776416..776916 [-], 50158584851NADH dehydrogenase subunit E 
Region 3: 986653..989007
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0748983225..983653 [-], 42958585005hypothetical protein 
2Wbm0749983877..986672 [-], 279658585006hypothetical protein 
3Wbm0750986653..989007 [-], 235558585007Type IV secretory pathway, VirB4 components  VirB4
4Wbm0751989038..989415 [-], 37858585008hypothetical protein 
5Wbm0752989526..990761 [-], 123658585009hypothetical protein 
6Wbm0753990873..991913 [-], 104158585010trans-2-enoyl-ACP reductase, FabK 
7Wbm0754991919..992392 [-], 47458585011cytochrome B561 
Region 4: 1051828..1066132
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#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0790 (pyrE)1047828..1048433 [+], 60658585047orotate phosphoribosyltransferase 
2Wbm07911050523..1051071 [-], 54958585048N-6 adenine-specific DNA methylase 
3Wbm07921051188..1051835 [-], 64858585049hypothetical protein 
4Wbm07931051828..1055067 [-], 324058585050Type IV secretory pathway, VirB6 components  VirB6
5Wbm07941055217..1058339 [-], 312358585051Type IV secretory pathway, VirB6 components  VirB6
6Wbm07951058336..1060738 [-], 240358585052Type IV secretory pathway, VirB6 components 
7Wbm07961060804..1063428 [-], 262558585053Type IV secretory pathway, VirB6 components  VirB6
8Wbm07971063421..1065826 [-], 240658585054type IV secretion system ATPase VirB4  VirB4
9Wbm07981065836..1066132 [-], 29758585055type IV secretion system protein VirB3  VirB3
10Wbm0799 (lysK)1066331..1067770 [+], 144058585056lysyl-tRNA synthetase 
11Wbm08001068652..1069641 [-], 99058585057glutamine amidotransferase domain-containing protein 
12Wbm0801 (coaD)1069887..1070390 [+], 50458585058phosphopantetheine adenylyltransferase 
13Wbm08021070459..1070656 [+], 19858585059NADH:ubiquinone oxidoreductase Fe-S subunit 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes
(1) Turner JD; Langley RS; Johnston KL; Gentil K; Ford L; Wu B; Graham M; Sharpley F; Slatko B; Pearlman E; Taylor MJ (2009). Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 284(33):22364-78. [PudMed:19458089] in_silico
(2) Foster J; Ganatra M; Kamal I; Ware J; Makarova K; Ivanova N; Bhattacharyya A; Kapatral V; Kumar S; Posfai J; Vincze T; Ingram J; Moran L; Lapidus A; Omelchenko M; Kyrpides N; Ghedin E; Wang S; Goltsman E; Joukov V; Ostrovskaya O; Tsukerman K; Mazur M; Comb D; Koonin E; Slatko B (2005). The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol. 3(4):e121. [PudMed:15780005]
in_silico This literature contains bioinformatics investigation