SecReT4
Effector Protein ID: 319898798
T4SS name [ID]VirB [230]
Gene symbol-
Locus tagBARCL_0629
StrainBartonella clarridgeiae 73
Repliconchromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon]
Location [Strand]687413..689536 [+]
ProductBartonella effector protein (Bep); substrate of VirB T4SS
Effector typeProtein
DescriptonBepB
T4CP requirementT4CP Depedent
Target/EffectionHomologous to BepB protein of Bartonella henselae.The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDE6YHH2
KEGG IDbcd:BARCL_0629
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 5.8e-12, Aligned region: 222..335
Protein Sequence: 707 a.a.     [Download]
>gi|319898798|ref|YP_004158891.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73]
MKKTKKGTIMPNSKLAGYPTLTKEELQKRQKILQSVISAYTIRNTPLHSNTLITLQGYAKGRYSLSEFNV
IMDTNLKAILNEVTDGNINSVSPDTINAHHAIRAIINLHQNFPGIRNIETANYCTLIIDELQKRRTIIDS
AINTHVIENISLHPSTLIALEEYTKGNYSVNEFDIVMDSIETTILDNLKNVNIDSATLNTINAHHRMKAI
IALNEESLPEKFDSSYLKYLHGRLFREQFEPTGHISDHPLTSKDGITASMLTVKILNSNNVFTEDKKIQE
SLQKFDQMLVAKNNLKGLSRKEFIDEAAKLFSSLSRIHPFKEGNEITQRMFFEKLAEAAGHQLDFSVVTK
ERMVRAYSDTIEKKDNVRSEVIEHLFEDISNPEKVSILKELIYNEFNIKCKDLNNTNIIMPRDDIPYLGI
YKGSIGNAIMVDTENSCVVCLKDYLTPKKLKGLKIGDRLIFKTLNKKNLDTILIPEEQLPPLTEDEIVQE
LVKNTIVQEKLEKIERYSKTVYKDSKILHEHIIMMNKNPENYRFFSDQIVSDPKSISDAANKKFRSNTDQ
KDIYKLGNAIDDYIMTVKHRKSLMVEQHNAQQKRLGTIVTMPSKAMQDVLNLPKNMQKETLKSSPLLYKE
LNNFISDVTFRLLPEEHKALCNADYKTLSESIGISESKAKTIIKLVTQSKELCESLKPVRPEQPTEMNIN
KTNSIRM
-
Nucleotide Sequence: 2124 bp     [Download]
>gi|319898193|ref|NC_014932.1|:687413-689536 Bartonella clarridgeiae 73, complete genome
ATGAAAAAAACGAAAAAAGGAACAATTATGCCAAATTCAAAATTAGCTGGTTATCCAACTCTAACAAAAG
AAGAATTACAAAAGCGCCAAAAAATCCTTCAGTCGGTCATTAGTGCCTATACTATTAGAAATACTCCTTT
GCACTCTAATACACTCATCACTTTACAAGGGTACGCAAAGGGACGTTATTCATTAAGTGAATTTAATGTT
ATCATGGACACTAATTTAAAAGCTATTCTGAATGAGGTAACAGATGGAAACATAAACAGTGTGTCTCCTG
ATACTATAAATGCACATCATGCAATAAGAGCAATTATTAATCTACACCAAAATTTTCCAGGTATTCGAAA
TATAGAGACAGCTAATTATTGTACTCTAATAATAGATGAATTACAAAAACGTCGCACAATTATTGATTCA
GCCATTAATACCCATGTTATTGAAAATATTTCTTTGCATCCTAGTACACTCATAGCTTTAGAAGAATATA
CAAAGGGAAACTATTCAGTAAATGAATTTGATATTGTTATGGATAGTATTGAAACAACGATTCTGGATAA
TTTAAAGAATGTGAATATAGATAGTGCGACTCTTAATACTATAAATGCGCATCATAGAATGAAAGCAATC
ATTGCCTTAAACGAAGAGTCTTTGCCAGAAAAGTTTGATTCTTCTTATTTAAAATATCTTCATGGACGTT
TATTTAGGGAACAGTTTGAACCGACTGGACATATTAGCGATCATCCACTGACATCTAAAGATGGTATAAC
TGCAAGCATGCTAACAGTGAAAATACTGAACTCAAATAATGTGTTTACAGAAGATAAAAAAATCCAAGAA
AGCTTACAGAAATTTGATCAAATGCTTGTTGCAAAGAATAATTTAAAAGGCTTATCGCGCAAAGAATTTA
TTGATGAGGCAGCAAAACTTTTTTCTTCTCTCAGCCGTATACATCCATTTAAAGAAGGCAACGAAATTAC
ACAACGAATGTTTTTTGAAAAGCTTGCAGAAGCTGCAGGTCATCAACTTGATTTTTCAGTTGTGACAAAA
GAACGCATGGTACGTGCCTACAGTGATACGATAGAGAAAAAAGATAATGTAAGGAGTGAAGTTATAGAAC
ATCTTTTTGAGGATATTTCCAATCCAGAAAAAGTAAGTATTTTAAAGGAACTTATCTATAACGAATTTAA
TATTAAGTGCAAAGATCTAAATAATACAAATATTATAATGCCACGTGATGATATACCCTATTTAGGTATT
TATAAAGGAAGTATTGGAAATGCTATTATGGTTGATACAGAGAATTCTTGTGTCGTATGCCTTAAAGATT
ATCTCACACCGAAAAAACTCAAAGGATTAAAGATTGGTGATAGGCTCATTTTTAAAACTTTAAACAAAAA
AAATTTAGATACAATTCTCATCCCAGAAGAACAATTACCTCCTTTGACGGAAGATGAAATTGTTCAAGAG
CTTGTAAAAAATACCATTGTCCAAGAAAAATTAGAAAAGATCGAGCGATATTCAAAAACTGTGTATAAAG
ATTCAAAAATACTGCATGAACATATAATAATGATGAATAAAAATCCAGAAAATTATAGATTTTTTTCCGA
TCAGATTGTTTCTGATCCAAAAAGTATTTCTGATGCAGCAAATAAAAAATTCAGATCTAACACAGATCAA
AAGGACATTTATAAACTTGGTAACGCAATTGATGATTATATTATGACTGTAAAACATCGTAAAAGTCTAA
TGGTTGAACAGCATAATGCACAACAAAAACGCCTTGGAACAATAGTAACAATGCCTAGCAAAGCAATGCA
AGATGTTCTTAACTTGCCAAAAAATATGCAGAAAGAAACTTTAAAGTCCTCTCCTCTCCTTTACAAAGAA
CTCAATAATTTTATAAGTGATGTTACCTTTCGTCTTTTACCAGAAGAGCATAAAGCGCTCTGTAATGCTG
ATTATAAAACACTCTCTGAAAGCATTGGTATATCAGAAAGTAAAGCGAAGACAATTATAAAACTTGTTAC
CCAATCCAAAGAGTTGTGTGAATCATTGAAACCAGTCAGACCTGAGCAGCCAACAGAAATGAATATAAAC
AAAACAAATTCTATAAGAATGTAG
 Primer design

Reference
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature