SecReT4
Effector Protein ID: 319898799
T4SS name [ID]VirB [230]
Gene symbol-
Locus tagBARCL_0630
StrainBartonella clarridgeiae 73
Repliconchromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon]
Location [Strand]689727..691361 [+]
ProductBartonella effector protein (Bep), substrate of VirB T4SS
Effector typeProtein
DescriptonBepA
T4CP requirementT4CP Depedent
Target/EffectionHomologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDE6YHH3
KEGG IDbcd:BARCL_0630
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 1.1e-13, Aligned region: 57..170
Protein Sequence: 544 a.a.     [Download]
>gi|319898799|ref|YP_004158892.1| Bartonella effector protein (Bep), substrate of VirB T4SS [Bartonella clarridgeiae 73]
MTISSDISLARNYAYPNSKTLKNKYGIMDFKKLEKKCTHDAKKVIVNLHQEPLPEKFDSSYLKYLHKCLF
EEAFEWAGHTRDLPFTFKDGTTAQMLMMKMPNSNIFFVAGNKIQESLQEFDQMLVAKNNLQGLSREEFID
EAAKLFSSLNYIHPFRGGNGPTQRVFFEKLAEAAGHRIDFSVITKERMIRTCINAIMLKGDEAHEAMKHL
FEDISNPEKVRVLKELFNHIPRLECKRLDNEYVVMPREGMTYTGIYKGGSLDSIIVETVDSCVICHKDYL
TPEQIKALKFSDEITFTVPINKDLDQILIPAEKLAPLREEEIIKKIENATYVQKSRIKIEFLSKLVYGDP
TILDKHMNLINKDPEMGQQLAEQIRNSPKSISKLEGFKIGLIRSPKREVAERNISEFSKAIIEHVDIVQY
TKRKILKEHQKEKKRVEQVIKRPSQEVQKILELQPNKWEEALKTESPEVLHKDLRGFLNKINSRLSISER
KNIDSADCETLAESIGISDSKAKIIIQAFHQGTELYKQLEIIKTDRSKVVTMAI
-
Nucleotide Sequence: 1635 bp     [Download]
>gi|319898193|ref|NC_014932.1|:689727-691361 Bartonella clarridgeiae 73, complete genome
ATGACAATATCTTCCGATATATCCTTAGCCCGTAATTATGCCTATCCTAACAGTAAAACATTAAAGAATA
AATATGGAATAATGGATTTTAAAAAACTTGAAAAGAAATGCACACATGATGCAAAAAAAGTAATCGTCAA
TTTGCATCAAGAACCGCTACCAGAAAAGTTTGATTCTTCTTATTTAAAATATCTCCATAAATGCTTATTT
GAAGAGGCATTTGAATGGGCCGGACATACCCGCGATCTCCCCTTTACATTTAAAGACGGCACAACTGCCC
AAATGTTAATGATGAAAATGCCGAATTCAAATATTTTTTTTGTAGCTGGTAACAAAATTCAAGAAAGCTT
ACAGGAATTTGACCAAATGCTTGTTGCAAAGAATAATTTGCAAGGTTTATCGCGCGAAGAATTTATTGAT
GAGGCAGCAAAGCTTTTTTCTTCTCTCAACTATATACATCCTTTCAGAGGTGGTAATGGACCTACACAGC
GAGTATTTTTTGAAAAGCTTGCGGAAGCTGCAGGTCATAGAATTGATTTTTCAGTTATAACAAAAGAGCG
GATGATACGCACCTGTATTAATGCGATAATGCTAAAGGGTGATGAAGCTCATGAAGCGATGAAACATTTA
TTTGAAGATATTTCCAATCCAGAAAAAGTACGTGTTTTAAAGGAATTATTCAATCACATACCTAGGCTTG
AGTGCAAACGTTTGGATAATGAATATGTTGTAATGCCACGTGAAGGTATGACCTATACAGGTATTTATAA
AGGAGGTAGTTTAGATTCTATCATAGTTGAAACAGTGGATTCTTGCGTCATATGTCATAAAGATTATCTT
ACACCAGAACAAATCAAGGCATTAAAATTCAGTGACGAAATTACCTTTACAGTTCCAATAAATAAAGATT
TAGATCAAATTCTTATCCCAGCAGAAAAGTTAGCTCCTTTGAGGGAAGAGGAAATAATCAAGAAGATTGA
AAATGCTACTTATGTTCAAAAAAGCCGAATAAAAATCGAGTTTTTATCAAAGCTTGTTTATGGAGATCCA
ACAATATTAGATAAGCATATGAATCTTATTAATAAAGATCCTGAAATGGGTCAACAGCTTGCCGAACAGA
TTAGAAATTCTCCTAAATCTATTTCTAAGCTTGAAGGTTTCAAAATAGGGCTTATAAGGAGTCCAAAACG
CGAGGTAGCTGAAAGAAATATTTCAGAATTTAGTAAAGCAATTATAGAACACGTGGATATTGTACAATAT
ACTAAAAGGAAAATTCTTAAAGAGCATCAAAAAGAAAAAAAACGTGTTGAACAAGTAATAAAAAGGCCTA
GCCAAGAAGTGCAAAAGATTCTTGAATTGCAACCAAATAAATGGGAAGAAGCTTTAAAGACAGAGAGTCC
TGAAGTGCTTCATAAAGATCTCCGCGGTTTTTTGAATAAAATCAATTCTCGTCTTTCTATAAGCGAGCGG
AAAAATATCGATTCTGCTGATTGTGAAACATTGGCTGAAAGTATTGGCATATCAGACAGTAAAGCAAAGA
TAATTATACAAGCTTTTCATCAAGGCACAGAATTATACAAACAGCTTGAAATAATTAAAACTGACCGCTC
GAAAGTAGTGACTATGGCCATCTGA
 Primer design

Reference
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature