SecReT4
Effector Protein ID: 319898800
T4SS name [ID]VirB [230]
Gene symbol-
Locus tagBARCL_0631
StrainBartonella clarridgeiae 73
Repliconchromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon]
Location [Strand]691657..693285 [+]
ProductBartonella effector protein (Bep); substrate of VirB T4SS
Effector typeProtein
DescriptonBepA
T4CP requirementT4CP Depedent
Target/EffectionHomologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDE6YHH4
KEGG IDbcd:BARCL_0631
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 4.8e-12, Aligned region: 57..169
Protein Sequence: 542 a.a.     [Download]
>gi|319898800|ref|YP_004158893.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73]
MTTSSDISLARNYAYPNSKTLKNKYGIMDFKKLEKKCTHDAKKVIVNLHQEPLPEKFDSSYLKYLHKCLF
EDAFEWAGHTRDLPFTFKDGTTAQMLMMKMPNSNIFFVASNKIQESLQEFDQMLVAKNNLQGLSREEFID
EAAKLFSSLNYIHPFRGGNEPTQQMFFEKLAEAAGHRIDFSIVTQERMIRACTDAITLKGDEAHEAMKHL
FEDISNPEKVRVLKELLNHIPRLECKRLDNEYVVMPREGMTYTGIYKGGSLDSIIVETVDSCVICHKDYL
TPEQIKALKPGNRVTFTVPINKDLDQILIPAEKLAPLREEEIIKKIKNTDCIKESRKGIDHLLKLVYGDP
TILDKHMNLINKDPEMGQQLAEQIRNSPKSISKLAGFKIWRIRSPKRRVAERNISSLSRAITQHVQIVKS
VKDKIFIEYKRKQKRLEQVVKIPSKEVRESLNLPKDIQKKALESSPSLHRDLCDFLCKVNSRLSMSELEH
IRDTNHKILAESIGISQSKAKIITQTFNKGVKLYKQFETIKADRSKIAAMTI
-
Nucleotide Sequence: 1629 bp     [Download]
>gi|319898193|ref|NC_014932.1|:691657-693285 Bartonella clarridgeiae 73, complete genome
ATGACAACATCTTCCGATATATCCTTAGCCCGTAATTATGCCTATCCTAACAGTAAAACATTAAAGAATA
AATATGGAATAATGGATTTTAAAAAACTTGAAAAGAAATGTACACATGATGCAAAAAAAGTAATCGTCAA
TTTGCATCAAGAACCGCTACCAGAAAAGTTTGATTCTTCTTATTTAAAATATCTCCATAAATGCTTATTT
GAAGACGCATTTGAATGGGCCGGACATACCCGCGATCTCCCCTTTACATTTAAAGACGGCACAACTGCCC
AAATGTTAATGATGAAAATGCCGAATTCAAATATTTTTTTTGTAGCTAGTAACAAAATTCAAGAAAGCTT
ACAGGAATTTGACCAAATGCTTGTTGCAAAGAATAATTTGCAAGGTTTATCGCGCGAAGAATTTATTGAT
GAGGCAGCAAAACTTTTTTCTTCTCTCAACTATATACATCCTTTCAGAGGTGGTAATGAACCTACACAAC
AAATGTTTTTTGAAAAGCTTGCGGAAGCTGCAGGTCATAGAATTGATTTTTCAATTGTGACACAAGAACG
CATGATACGTGCTTGTACTGATGCGATAACTCTAAAAGGTGATGAAGCTCATGAAGCGATGAAACATTTA
TTTGAAGATATTTCCAATCCAGAAAAAGTACGTGTTTTAAAGGAATTACTCAATCACATACCTAGGCTTG
AGTGCAAACGTTTGGATAATGAATATGTTGTAATGCCACGTGAAGGTATGACCTATACAGGTATTTACAA
AGGAGGTAGTTTAGATTCTATTATAGTTGAAACAGTGGATTCTTGCGTCATATGTCATAAAGATTATCTT
ACACCAGAACAAATCAAGGCATTAAAACCCGGTAATCGGGTTACCTTTACAGTTCCAATAAATAAAGATT
TAGATCAAATTCTTATCCCAGCAGAAAAGTTAGCTCCTTTGAGGGAAGAGGAAATAATCAAAAAGATTAA
AAATACTGATTGTATTAAAGAAAGCCGAAAAGGAATTGACCATTTATTAAAGCTTGTTTATGGAGATCCA
ACAATATTAGATAAGCATATGAATCTTATTAATAAAGATCCTGAAATGGGTCAACAGCTTGCCGAACAGA
TTAGAAATTCTCCTAAATCTATTTCTAAACTCGCAGGCTTCAAAATATGGCGTATAAGGAGTCCAAAACG
CAGGGTAGCTGAAAGAAATATTTCAAGCCTCAGTCGAGCAATTACACAACATGTGCAAATTGTAAAATCT
GTTAAAGATAAAATTTTTATAGAGTATAAAAGAAAACAAAAACGACTTGAGCAAGTAGTAAAAATACCTA
GTAAAGAAGTGCGAGAGAGTCTTAATTTGCCAAAGGATATACAAAAAAAAGCTTTAGAGTCTTCTCCTTC
ACTTCACAGAGATCTTTGTGATTTTCTGTGTAAAGTCAATTCTCGTCTTTCAATGAGTGAGCTAGAACAT
ATTCGTGATACTAATCATAAAATACTGGCTGAAAGTATTGGCATATCACAAAGTAAAGCGAAGATAATTA
CACAAACTTTTAATAAAGGAGTAAAATTATACAAACAATTTGAAACAATCAAAGCTGACCGTTCGAAAAT
AGCGGCTATGACCATCTGA
 Primer design

Reference
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature