SecReT4
Effector Protein ID: 319898807
T4SS name [ID]VirB [231]
Gene symbol-
Locus tagBARCL_0639
StrainBartonella clarridgeiae 73
Repliconchromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon]
Location [Strand]700743..702665 [-]
ProductBartonella effector protein (Bep); substrate of VirB T4SS
Effector typeProtein
DescriptonBepB
T4CP requirementT4CP Depedent
Target/EffectionHomologous to BepB protein of Bartonella henselae.The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDE6YHI2
KEGG IDbcd:BARCL_0639
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 6.3e-16, Aligned region: 145..258
Protein Sequence: 640 a.a.     [Download]
>gi|319898807|ref|YP_004158900.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73]
MPIKLFNNSVSLTAEELQKRRRIVDSAIHTHTIENITLHSDTLLTLERYAEGDYSLDEFNIIMDTVERII
LDDMQITITEEPQVEETIISSNFNSPSPYNYIYPRSWVLKNKHGIKDNQVLGAVSGHHVVKAILNLHCEP
LPERFDSSYLKYLHKRLFENTFEWAGNTRDVTFTFADGTAAIMPTMKKLNSNNSFLTSERIPKELKNIDK
ILAEHDNLKGLSRQDFVHKATGIFTFLNHIHPFRDGNGRAQRMFFEKLAEAAGHQLDFSVITAERMVVSS
MVSITDTGNIGDIRAIGHMLEDISNPENVYVLKEFMNSMNDIERKNAQKKIILTPNKDEIYTGIYENDSP
NSILLKTDRDYIAKPLYMIFKKDYFSPEQLKTLKVGNQFSFTVPIKENVKDLENLLIPKERLAFLTEEQI
VERITNHHDVQSKREEINFYAKRVYRKLKKFNAKIEMISQNTQFGLELVKQITNSPESISKLAGKKILGI
GNSKHEIAKQNIYILVQKIDEYVNTVKRVKSVILGEYLIEQQRLATVVEMPSKEIQNIFNLPKDMQKEAL
KSSPSLHEELNNFIKKIRCRLTLKEYKLLRDANYKELAESVGISENRAKQIKEIFTQSKILQNSLKQVRF
GNAQTMNMVS
-
Nucleotide Sequence: 1923 bp     [Download]
>gi|319898193|ref|NC_014932.1|:c702665-700743 Bartonella clarridgeiae 73, complete genome
ATGCCAATAAAACTATTTAATAATTCTGTATCTTTGACAGCAGAAGAATTACAAAAACGTCGCCGAATCG
TTGATTCGGCGATTCACACTCACACTATTGAAAATATTACTTTGCATTCTGATACACTTCTAACTTTAGA
AAGATATGCAGAAGGAGATTATTCATTAGATGAATTTAATATTATTATGGATACTGTTGAACGAATTATT
CTGGACGATATGCAGATTACAATTACAGAAGAACCGCAAGTGGAAGAAACCATAATATCATCTAACTTTA
ATTCCCCATCACCTTACAATTATATCTATCCTAGAAGTTGGGTACTGAAAAATAAACACGGAATAAAAGA
CAATCAAGTTCTTGGTGCAGTAAGTGGACATCACGTGGTGAAGGCAATCCTTAACCTACACTGTGAACCT
CTACCAGAACGGTTTGATTCTTCTTATCTAAAATATCTTCATAAACGCTTGTTTGAAAATACATTTGAAT
GGGCTGGAAATACTCGCGATGTTACATTTACATTTGCAGATGGAACAGCTGCTATTATGCCAACAATGAA
AAAATTGAACTCAAACAATTCTTTTCTAACAAGTGAGAGAATTCCCAAAGAACTAAAAAATATAGACAAA
ATACTTGCAGAGCACGATAACCTTAAAGGACTATCGCGTCAAGATTTTGTTCATAAAGCAACGGGTATAT
TTACTTTTCTTAATCACATACATCCATTCAGAGATGGTAATGGGCGTGCACAACGAATGTTTTTTGAAAA
ACTCGCTGAAGCTGCAGGTCATCAACTTGATTTTTCAGTTATCACAGCAGAACGTATGGTGGTTTCCAGT
ATGGTTTCTATAACGGATACTGGTAATATAGGTGATATAAGAGCTATAGGACATATGCTTGAAGATATTT
CTAATCCAGAAAACGTATATGTTTTAAAGGAATTCATGAACTCCATGAATGATATCGAGCGTAAAAATGC
GCAGAAAAAAATTATTTTAACGCCAAATAAAGATGAAATTTATACAGGCATCTATGAAAATGATAGCCCA
AATTCTATTCTACTCAAAACAGATCGTGATTATATTGCAAAACCGCTTTATATGATCTTTAAGAAAGATT
ATTTTTCACCAGAACAACTTAAGACATTAAAAGTCGGTAATCAGTTTTCCTTTACAGTTCCAATAAAAGA
AAATGTAAAAGATTTAGAAAACCTTCTCATTCCAAAAGAAAGATTAGCTTTTTTAACTGAAGAGCAAATT
GTTGAAAGGATTACAAATCATCACGATGTCCAATCAAAACGAGAAGAGATCAATTTTTATGCAAAGCGTG
TTTATCGCAAGTTAAAAAAATTTAACGCAAAGATAGAGATGATTAGTCAAAATACACAGTTTGGTCTAGA
GCTTGTTAAGCAGATTACTAATTCTCCTGAATCTATATCTAAATTAGCAGGTAAGAAAATATTAGGCATA
GGAAACTCAAAACACGAAATAGCTAAACAAAATATTTATATACTTGTTCAAAAAATTGATGAATATGTGA
ATACTGTAAAACGTGTGAAAAGTGTAATTCTTGGAGAGTATCTAATTGAACAACAACGTCTTGCGACAGT
AGTGGAAATGCCCAGCAAAGAAATACAAAATATTTTTAACTTGCCAAAAGATATGCAGAAAGAAGCTTTG
AAGTCCTCTCCTTCGCTGCACGAAGAACTCAATAATTTTATAAAAAAAATCCGTTGCCGTCTTACATTAA
AAGAGTATAAATTGCTCCGTGATGCTAACTATAAAGAACTCGCTGAAAGCGTTGGCATATCAGAAAATAG
AGCAAAGCAAATTAAAGAAATCTTTACGCAAAGCAAAATATTACAAAATTCATTGAAACAAGTCAGATTT
GGTAACGCACAAACAATGAATATGGTTAGCTAA
 Primer design

Reference
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature