SecReT4
Effector Protein ID: 319898808
T4SS name [ID]VirB [231]
Gene symbol-
Locus tagBARCL_0640
StrainBartonella clarridgeiae 73
Repliconchromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon]
Location [Strand]702829..704481 [-]
ProductBartonella effector protein (Bep); substrate of VirB T4SS
Effector typeProtein
DescriptonBepA
T4CP requirementT4CP Depedent
Target/EffectionHomologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDE6YHI3
KEGG IDbcd:BARCL_0640
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 4.3e-16, Aligned region: 63..176
Protein Sequence: 550 a.a.     [Download]
>gi|319898808|ref|YP_004158901.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73]
MVKRLQNALRRNKNSSCDYTYSGSNTLKNKHGIQDSLYLDKKSQLLSEKIAVQLRQEPLPKNFDSSYLKY
LHKCLFEEMFEWAGHTRDLPFTFADGTTAEMVNVTIPNSDVFFQESQKIAKSLQKFDQALIEKKQLKDLS
REKFVEEAVKLFSFLNYVHPFRDGNGRAQRMFFEKLAEAAGHQLDFSIATKQRMTFACRDAIPVKGNVNY
KTMQHLFEDISNPKKVHILRNFLCSLPQYERNYMDSHVVIVPRDNVIYTGRYKNSSSDSIIIVTKDSYIV
CCKDHLTPEKLKTLKCGDTVTFAIPGNKDLDQILIPAEKLAPLKKEELLEKIRNDTAIQNCEKEIKHLSK
LVYGNSQKLNRSIEFIKQTAEDNEKTSNWLLKHLSTGDDLAGLTICGIKTPKRRTAERNILPLNQKIRTY
ISIVESSKNKIMQNHHLEQKRLENSVEMPSKAVQDILVMPQDIRRQKLTSKNCIELQKELCHFLCKVNSR
LSKDQSKAIRKGNYKEIAESIGMSESKAQTLIVIFNETREVYQQLQKIKMNRSTQMAMAI
-
Nucleotide Sequence: 1653 bp     [Download]
>gi|319898193|ref|NC_014932.1|:c704481-702829 Bartonella clarridgeiae 73, complete genome
ATGGTAAAAAGACTACAGAATGCTTTAAGAAGAAATAAAAATTCATCTTGTGATTATACTTATTCTGGCA
GTAACACATTAAAAAATAAACATGGAATCCAAGATTCTCTGTATCTTGACAAAAAAAGTCAGTTGCTTTC
AGAGAAAATAGCTGTTCAGTTACGTCAAGAGCCATTACCAAAAAACTTTGATTCTTCCTATTTGAAATAT
CTTCATAAATGCTTATTTGAGGAAATGTTTGAATGGGCTGGACATACCCGCGATCTTCCATTTACATTTG
CAGATGGCACAACTGCCGAAATGGTAAATGTAACAATACCAAACTCAGATGTTTTTTTTCAAGAGAGTCA
AAAAATTGCAAAAAGCTTACAGAAATTTGATCAAGCTCTCATTGAGAAGAAACAATTAAAAGATTTATCG
CGTGAAAAATTTGTCGAGGAGGCAGTAAAGCTTTTTTCTTTTCTCAATTATGTACATCCATTCAGAGATG
GTAATGGACGTGCACAACGAATGTTTTTTGAAAAGCTTGCAGAAGCTGCAGGTCATCAACTTGATTTTTC
AATTGCTACAAAACAACGCATGACATTTGCCTGTAGAGATGCAATACCTGTAAAAGGTAATGTAAATTAT
AAAACGATGCAACATCTTTTCGAAGATATCTCTAATCCAAAAAAAGTGCATATTTTAAGGAATTTTTTAT
GCTCTTTGCCTCAATATGAACGTAATTATATGGATAGTCACGTTGTTATAGTACCACGTGATAATGTAAT
CTATACGGGTAGATATAAAAATAGTAGTTCAGATTCTATTATAATTGTAACAAAAGATTCATATATTGTA
TGCTGTAAAGATCATTTAACACCAGAAAAACTGAAGACATTAAAATGCGGTGATACAGTTACCTTTGCAA
TTCCAGGAAATAAAGATTTAGATCAAATTCTCATTCCAGCAGAAAAATTAGCTCCTTTAAAGAAAGAAGA
GTTACTCGAAAAGATTAGAAACGATACTGCGATTCAAAACTGCGAAAAAGAAATCAAACATTTATCAAAA
CTTGTCTATGGCAATTCACAAAAGTTAAATCGCAGTATAGAGTTTATTAAGCAAACAGCAGAAGATAATG
AAAAAACCTCTAACTGGCTTTTAAAGCATCTTTCTACCGGCGATGATCTTGCGGGTTTAACAATATGCGG
CATAAAAACTCCAAAACGCAGAACAGCTGAAAGAAATATTTTACCACTCAATCAAAAAATTCGAACATAT
ATTTCTATTGTAGAATCTTCTAAAAATAAAATTATGCAAAATCATCATTTAGAACAAAAACGGCTTGAAA
ATTCAGTAGAAATGCCTAGCAAAGCAGTGCAGGATATTCTTGTTATGCCACAGGATATAAGGAGACAAAA
GTTAACCTCAAAGAATTGTATTGAACTTCAAAAAGAGCTTTGTCATTTTTTGTGTAAAGTCAATTCTCGT
CTTTCAAAAGACCAGAGTAAAGCAATCAGAAAAGGTAATTATAAAGAAATCGCTGAAAGCATTGGTATGT
CAGAAAGTAAAGCACAAACTCTTATAGTAATTTTTAATGAAACAAGAGAAGTATACCAACAACTTCAAAA
AATCAAAATGAATAGGTCAACACAGATGGCTATGGCTATCTAA
 Primer design

Reference
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature