SecReT4
Effector Protein ID: 33603865
T4SS name [ID]Ptl [379]
Gene symbolptxD
Locus tagBB4892
StrainBordetella bronchiseptica RB50
Repliconchromosome [GenBank: NC_002927] [Browse all T4SS(s) in this replicon]
Location [Strand]5200486..5200944 [+]
Producttoxin subunit 4
Effector typeProtein
DescriptonPtxD
T4CP requirementT4CP Indepedent
Target/EffectionA subunit of pertussis toxin (PT). PT is involved in the colonization of the respiratory tract and the establishment of infection of Bordetella pertussis causing whooping cough
UniProt IDQ7WDU6
KEGG IDbbr:BB4892
PDB IDNA
Domain hit(s) vs Pfam Pertus-S4-tox [PF09275], Evalue: 4.7e-77, Aligned region: 43..152
Protein Sequence: 152 a.a.     [Download]
>gi|33603865|ref|NP_891425.1| ptxD gene product [Bordetella bronchiseptica RB50]
MLRRFLTRTTAPGQGGARRPRVRALAWLLASGTMMHLHPAQADVPYVLVKTNMVVTSVAMKPYEVNPTRM
LVCGIAAKLGAAASSPDAHVPFCFGKDLKRSGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELI
RMVECSGKQDCP
-
Nucleotide Sequence: 459 bp     [Download]
>gi|33598993|ref|NC_002927.3|:5200486-5200944 Bordetella bronchiseptica RB50 chromosome, complete genome
ATGCTGAGACGCTTCCTCACTCGAACCACCGCCCCGGGACAGGGCGGCGCCCGCCGGCCGCGCGTGCGCG
CCCTGGCGTGGTTGCTGGCATCCGGCACGATGATGCATCTTCACCCCGCCCAGGCCGACGTGCCTTATGT
GCTGGTGAAGACCAATATGGTGGTCACCAGCGTGGCCATGAAGCCGTATGAAGTCAACCCGACGCGCATG
CTGGTCTGCGGCATCGCCGCCAAGCTGGGCGCCGCGGCCAGCAGCCCGGACGCGCACGTGCCTTTCTGCT
TCGGCAAGGATCTCAAGCGCTCCGGCAGCAGTCCCATGGAAGTCATGTTGCGCGCCGTCTTCATGCAACA
ACGGCCGCTGCGCATGTTCCTGGGTCCCAAGCAACTCACTTTCGAAGGCAAGCCCGCGCTCGAACTGATC
CGGATGGTCGAGTGCAGCGGCAAGCAGGATTGCCCCTGA
 Primer design

Reference
(1) Parkhill J; Sebaihia M; Preston A; Murphy LD; Thomson N; Harris DE; Holden MT; Churcher CM; Bentley SD; Mungall KL; Cerdeno-Tarraga AM; Temple L; James K; Harris B; Quail MA; Achtman M; Atkin R; Baker S; Basham D; Bason N; Cherevach I; Chillingworth T; Collins M; Cronin A; Davis P; Doggett J; Feltwell T; Goble A; Hamlin N; Hauser H; Holroyd S; Jagels K; Leather S; Moule S; Norberczak H; O'Neil S; Ormond D; Price C; Rabbinowitsch E; Rutter S; Sanders M; Saunders D; Seeger K; Sharp S; Simmonds M; Skelton J; Squares R; Squares S; Stevens K; Unwin L; Whitehead S; Barrell BG; Maskell DJ (2003). Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 35(1):32-40. [PudMed:12910271]