SecReT4
Effector Protein ID: 33603867
T4SS name [ID]Ptl [379]
Gene symbolptxC
Locus tagBB4894
StrainBordetella bronchiseptica RB50
Repliconchromosome [GenBank: NC_002927] [Browse all T4SS(s) in this replicon]
Location [Strand]5201401..5202084 [+]
Producttoxin subunit 3
Effector typeProtein
DescriptonPtxC
T4CP requirementT4CP Indepedent
Target/EffectionA subunit of pertussis toxin (PT). PT is involved in the colonization of the respiratory tract and the establishment of infection of Bordetella pertussis causing whooping cough
UniProt IDQ7WDU4
KEGG IDbbr:BB4894
PDB IDNA
Domain hit(s) vs Pfam Pertussis_S2S3 [PF02918], Evalue: 3.5e-54, Aligned region: 119..226
APT [PF03440], Evalue: 9.5e-35, Aligned region: 32..117
Protein Sequence: 227 a.a.     [Download]
>gi|33603867|ref|NP_891427.1| ptxC gene product [Bordetella bronchiseptica RB50]
MLINNKKLLHHILPILLLALLGMRTARAVAPSIVIPPKALLTKQGGAYGRCPNGTRALTAAELRGSAELQ
TYLRQITPGWSIYGLYDGTYLGQSYGGIIKDAPPGGGFIYHETFCITTIYYTGQPDTDHYYSKVTATRLL
ASTNSGLCAVFARDGKPLIGACTRPYQSSYGDMYDVLRRLLYMVYMSGLAVRVHVSKEEQYYDYEDATFE
TYALTGISICNPAASIC
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Nucleotide Sequence: 684 bp     [Download]
>gi|33598993|ref|NC_002927.3|:5201401-5202084 Bordetella bronchiseptica RB50 chromosome, complete genome
ATGCTGATCAACAACAAGAAGCTGCTCCATCACATTCTGCCCATCCTGCTGCTCGCCCTGCTGGGCATGC
GCACGGCCCGGGCCGTTGCGCCAAGCATCGTCATCCCGCCGAAGGCCCTGCTCACCAAACAGGGCGGCGC
CTATGGGCGCTGCCCGAACGGAACCCGCGCCTTGACCGCGGCGGAACTGCGCGGCAGCGCCGAATTGCAG
ACGTATTTGCGACAGATAACGCCCGGCTGGTCCATATACGGTCTGTATGACGGTACGTACCTGGGCCAGT
CGTACGGCGGCATCATCAAGGACGCGCCGCCCGGCGGCGGGTTCATTTATCACGAAACTTTCTGCATCAC
GACCATCTACTACACCGGACAGCCGGATACAGATCACTACTACAGCAAGGTCACGGCCACGCGCCTGCTG
GCCAGCACCAACAGCGGGCTGTGCGCGGTCTTCGCCAGGGATGGAAAACCGCTCATCGGCGCCTGCACCC
GCCCGTATCAAAGCTCGTACGGAGACATGTACGACGTGCTGCGGCGCTTGCTGTACATGGTCTATATGTC
CGGTCTTGCCGTACGCGTCCACGTCAGCAAGGAAGAACAGTATTACGACTATGAAGACGCCACGTTCGAG
ACCTATGCCCTCACCGGTATCTCCATCTGCAACCCGGCGGCATCCATATGCTGA
 Primer design

Reference
(1) Parkhill J; Sebaihia M; Preston A; Murphy LD; Thomson N; Harris DE; Holden MT; Churcher CM; Bentley SD; Mungall KL; Cerdeno-Tarraga AM; Temple L; James K; Harris B; Quail MA; Achtman M; Atkin R; Baker S; Basham D; Bason N; Cherevach I; Chillingworth T; Collins M; Cronin A; Davis P; Doggett J; Feltwell T; Goble A; Hamlin N; Hauser H; Holroyd S; Jagels K; Leather S; Moule S; Norberczak H; O'Neil S; Ormond D; Price C; Rabbinowitsch E; Rutter S; Sanders M; Saunders D; Seeger K; Sharp S; Simmonds M; Skelton J; Squares R; Squares S; Stevens K; Unwin L; Whitehead S; Barrell BG; Maskell DJ (2003). Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 35(1):32-40. [PudMed:12910271]