SecReT4
SecReT4 contains data from 925 references related to type IV secretion systems (T4SSs). Last Update: Aug 11, 2012

Categories (Literatures contain following contents are categorized)
reviews experimental studies bioinformatics genome sequencing T4SS component T4SS effectors
conjugation DNA uptake and release effector translocation structural study protein interaction other
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Number of references found for the 'experiment' category : 527

References
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(7) Pham KT et al (2012). CagI is an essential component of the Helicobacter pylori Cag type IV secretion system and forms a complex with CagL. PLoS One. 7(4):e35341. [PudMed:22493745]
(8) Sa JC et al (2012). The virB-encoded type IV secretion system is critical for establishment of infection and persistence of Brucella ovis infection in mice. Vet Microbiol. . [PudMed:22483850]
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(13) Liu H et al (2012). Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating host MnSOD. Cell Microbiol. 14(7):1037-50. [PudMed:22348527]
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(21) Altman E et al (2012). Helicobacter pylori isolates from Greek children express type 2 and type 1 Lewis and alpha1,6-glucan antigens in conjunction with a functional type IV secretion system. J Med Microbiol. 61(Pt 4):559-66. [PudMed:22160312]
(22) Aviles-Jimenez F et al (2012). In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer. Infect Immun. 80(2):594-601. [PudMed:22124657]
(23) Wang H et al (2012). Characterization of CagI in the cag pathogenicity island of Helicobacter pylori. Curr Microbiol. 64(2):191-6. [PudMed:22109855]
(24) Wang HJ et al (2012). Helicobacter pylori cholesteryl glucosides interfere with host membrane phase and affect type IV secretion system function during infection in AGS cells. Mol Microbiol. 83(1):67-84. [PudMed:22053852]
(25) Morse K et al (2012). Association and evidence for linked recognition of type IV secretion system proteins VirB9-1, VirB9-2, and VirB10 in Anaplasma marginale. Infect Immun. 80(1):215-27. [PudMed:22038917]
(26) Caswell CC et al (2012). The RNA chaperone Hfq independently coordinates expression of the VirB type IV secretion system and the LuxR-type regulator BabR in Brucella abortus 2308. J Bacteriol. 194(1):3-14. [PudMed:22020650]
(27) Conradi J et al (2012). Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins alpha(V)beta (3) and alpha (5)beta (1). Amino Acids. 43(1):219-32. [PudMed:21915696]
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(30) Lai CH et al (2011). Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain. FEMS Microbiol Lett. 323(2):155-63. [PudMed:22092715]
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(32) Lang S et al (2011). An activation domain of plasmid R1 TraI protein delineates stages of gene transfer initiation. Mol Microbiol. 82(5):1071-85. [PudMed:22066957]
(33) Truttmann MC et al (2011). Bartonella henselae engages inside-out and outside-in signaling by integrin beta1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci. 124(Pt 21):3591-602. [PudMed:22045736]
(34) Truttmann MC et al (2011). BID-F1 and BID-F2 domains of Bartonella henselae effector protein BepF trigger together with BepC the formation of invasome structures. PLoS One. 6(10):e25106. [PudMed:22043280]
(35) Aguilar J et al (2011). Membrane and core periplasmic Agrobacterium tumefaciens virulence Type IV secretion system components localize to multiple sites around the bacterial perimeter during lateral attachment to plant cells. MBio. 2(6):e00218-11. [PudMed:22027007]
(36) Jain S et al (2011). Processing and maturation of the pilin of the type IV secretion system encoded within the gonococcal genetic island. J Biol Chem. 286(51):43601-10. [PudMed:22006923]
(37) Mori N et al (2011). Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection. World J Gastroenterol. 17(32):3691-9. [PudMed:21990950]
(38) Shaffer CL et al (2011). Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog. 7(9):e1002237. [PudMed:21909278]
(39) Fernandez-Gonzalez E et al (2011). Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. J Bacteriol. 193(22):6257-65. [PudMed:21908662]
(40) Paredes-Cervantes V et al (2011). Comparative proteome analysis of Brucella abortus 2308 and its virB type IV secretion system mutant reveals new T4SS-related candidate proteins. J Proteomics. 74(12):2959-71. [PudMed:21875698]
(41) Schroder G et al (2011). Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae. Proc Natl Acad Sci U S A. 108(35):14643-8. [PudMed:21844337]
(42) Hilbi H et al (2011). Anchors for effectors: subversion of phosphoinositide lipids by legionella. Front Microbiol. 2:91. [PudMed:21833330]
(43) Nagase L et al (2011). Potentiation of Helicobacter pylori CagA protein virulence through homodimerization. J Biol Chem. 286(38):33622-31. [PudMed:21813645]
(44) Andrieux L et al (2011). A single amino acid change in the transmembrane domain of the VirB8 protein affects dimerization, interaction with VirB10 and Brucella suis virulence. FEBS Lett. 585(15):2431-6. [PudMed:21763312]
(45) Tan Y et al (2011). Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature. 475(7357):506-9. [PudMed:21734656]
(46) Marchesini MI et al (2011). In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system. Cell Microbiol. 13(8):1261-74. [PudMed:21707904]
(47) Flannery EL et al (2011). Self-transmissibility of the integrative and conjugative element ICEPm1 between clinical isolates requires a functional integrase, relaxase, and type IV secretion system. J Bacteriol. 193(16):4104-12. [PudMed:21665966]
(48) Carey KL et al (2011). The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS Pathog. 7(5):e1002056. [PudMed:21637816]
(49) Steininger S et al (2011). Purpose of recently detected inhibitory domain of the Helicobacter pylori protein CagA. Gut Microbes. 2(3):167-72. [PudMed:21637033]
(50) Ishijima N et al (2011). BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity. J Biol Chem. 286(28):25256-64. [PudMed:21596743]
(51) Souza DP et al (2011). A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a N0 domain found in outer membrane transport proteins. PLoS Pathog. 7(5):e1002031. [PudMed:21589901]
(52) Kumar Pachathundikandi S et al (2011). Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-alpha. PLoS One. 6(5):e19614. [PudMed:21573018]
(53) Zhu W et al (2011). Protein expression, crystallization and preliminary X-ray crystallographic studies of LidA from Legionella pneumophila. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67(Pt 5):637-9. [PudMed:21543880]
(54) Arnold IC et al (2011). The C-terminally encoded, MHC class II-restricted T cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia. J Immunol. 186(11):6165-72. [PudMed:21518972]
(55) de Barsy M et al (2011). Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cell Microbiol. 13(7):1044-58. [PudMed:21501366]
(56) Pena A et al (2011). Autoinhibitory regulation of TrwK, an essential VirB4 ATPase in type IV secretion systems. J Biol Chem. 286(19):17376-82. [PudMed:21454654]
(57) Hanna N et al (2011). The virB operon is essential for lethality of Brucella microti in the Balb/c murine model of infection. J Infect Dis. 203(8):1129-35. [PudMed:21451001]
(58) Banta LM et al (2011). An Agrobacterium VirB10 mutation conferring a type IV secretion system gating defect. J Bacteriol. 193(10):2566-74. [PudMed:21421757]
(59) Ramirez-Diaz MI et al (2011). Nucleotide sequence of Pseudomonas aeruginosa conjugative plasmid pUM505 containing virulence and heavy-metal resistance genes. Plasmid. 66(1):7-18. [PudMed:21421005]
(60) Schneider S et al (2011). Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells. Infect Immun. 79(6):2362-71. [PudMed:21402757]
(61) Sivanesan D et al (2011). The dimer interface of Agrobacterium tumefaciens VirB8 is important for type IV secretion system function, stability, and association of VirB2 with the core complex. J Bacteriol. 193(9):2097-106. [PudMed:21398549]
(62) Fontana MF et al (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206]
(63) Jameson-Lee M et al (2011). DsbA2 (27 kDa Com1-like protein) of Legionella pneumophila catalyses extracytoplasmic disulphide-bond formation in proteins including the Dot/Icm type IV secretion system. Mol Microbiol. 80(3):835-52. [PudMed:21375592]
(64) Engel P et al (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280]
(65) Hervet E et al (2011). Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun. 79(5):1936-50. [PudMed:21321072]
(66) Durand E et al (2011). Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system. BMC Struct Biol. 11:4. [PudMed:21266026]
(67) Li M et al (2011). GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2. Mol Microbiol. 79(6):1670-83. [PudMed:21244532]
(68) Voth DE et al (2011). The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates. J Bacteriol. 193(7):1493-503. [PudMed:21216993]
(69) Palanivelu DV et al (2011). Fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Sci. 20(3):492-9. [PudMed:21213248]
(70) Pelz C et al (2011). A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology. J Biol Chem. 286(11):8999-9008. [PudMed:21212271]
(71) Patra R et al (2011). Intact cag pathogenicity island of Helicobacter pylori without disease association in Kolkata, India. Int J Med Microbiol. 301(4):293-302. [PudMed:21195664]
(72) Paschos A et al (2011). An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun. 79(3):1033-43. [PudMed:21173315]
(73) Kienesberger S et al (2011). Interbacterial macromolecular transfer by the Campylobacter fetus subsp. venerealis type IV secretion system. J Bacteriol. 193(3):744-58. [PudMed:21115658]
(74) Dominguez NM et al (2011). XerCD-mediated site-specific recombination leads to loss of the 57-kilobase gonococcal genetic island. J Bacteriol. 193(2):377-88. [PudMed:21075927]
(75) Scheidegger F et al (2011). The Bartonella henselae VirB/Bep system interferes with vascular endothelial growth factor (VEGF) signalling in human vascular endothelial cells. Cell Microbiol. 13(3):419-31. [PudMed:21044238]
(76) Truttmann MC et al (2011). Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells. Cell Microbiol. 13(2):284-99. [PudMed:20964799]
(77) Lorenz J et al (2011). Legionella pneumophila-induced IkappaBzeta-dependent expression of interleukin-6 in lung epithelium. Eur Respir J. 37(3):648-57. [PudMed:20650996]
(78) Arnold IC et al (2011). Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology. 140(1):199-209. [PudMed:20600031]
(79) Zhong Q et al (2011). Characterization of peptidoglycan hydrolase in Cag pathogenicity island of Helicobacter pylori. Mol Biol Rep. 38(1):503-9. [PudMed:20358296]
(80) Backert S et al (2010). PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function. Gut Microbes. 1(2):94-99. [PudMed:21326916]
(81) Lang S et al (2010). Molecular recognition determinants for type IV secretion of diverse families of conjugative relaxases. Mol Microbiol. 78(6):1539-55. [PudMed:21143323]
(82) Chen C et al (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666]
(83) Luhrmann A et al (2010). Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A. 107(44):18997-9001. [PudMed:20944063]
(84) Blanca-Ordonez H et al (2010). pSymA-dependent mobilization of the Sinorhizobium meliloti pSymB megaplasmid. J Bacteriol. 192(23):6309-12. [PudMed:20889746]
(85) Jurik A et al (2010). The coupling protein Cagbeta and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA protein. Infect Immun. 78(12):5244-51. [PudMed:20876293]
(86) Liu XY et al (2010). Genome-wide screening reveals the genetic determinants of an antibiotic insecticide in Bacillus thuringiensis. J Biol Chem. 285(50):39191-200. [PudMed:20864531]
(87) Saisongkorh W et al (2010). Evidence of transfer by conjugation of type IV secretion system genes between Bartonella species and Rhizobium radiobacter in amoeba. PLoS One. 5(9):e12666. [PudMed:20856925]
(88) Dozot M et al (2010). Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen Brucella melitensis. PLoS One. 5(9). [PudMed:20844759]
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(90) Schroeder GN et al (2010). Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins. J Bacteriol. 192(22):6001-16. [PudMed:20833813]
(91) Olbermann P et al (2010). A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island. PLoS Genet. 6(8):e1001069. [PudMed:20808891]
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(97) Kerr JE et al (2010). Evidence for VirB4-mediated dislocation of membrane-integrated VirB2 pilin during biogenesis of the Agrobacterium VirB/VirD4 type IV secretion system. J Bacteriol. 192(19):4923-34. [PudMed:20656905]
(98) Sonthayanon P et al (2010). High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen Orientia tsutsugamushi. PLoS Negl Trop Dis. 4(7):e752. [PudMed:20651929]
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(100) Vayssier-Taussat M et al (2010). The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes. PLoS Pathog. 6(6):e1000946. [PudMed:20548954]
(101) Lurie-Weinberger MN et al (2010). The origins of eukaryotic-like proteins in Legionella pneumophila. Int J Med Microbiol. 300(7):470-81. [PudMed:20537944]
(102) Tegtmeyer N et al (2010). A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem. 285(30):23515-26. [PudMed:20507990]
(103) Fischer W et al (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826]
(104) Murata-Kamiya N et al (2010). Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein. Cell Host Microbe. 7(5):399-411. [PudMed:20478541]
(105) Tsai YL et al (2010). The small heat-shock protein HspL is a VirB8 chaperone promoting type IV secretion-mediated DNA transfer. J Biol Chem. 285(26):19757-66. [PudMed:20427270]
(106) Sivanesan D et al (2010). Quantitative analysis of VirB8-VirB9-VirB10 interactions provides a dynamic model of type IV secretion system core complex assembly. Biochemistry. 49(21):4483-93. [PudMed:20426418]
(107) Quebatte M et al (2010). The BatR/BatS two-component regulatory system controls the adaptive response of Bartonella henselae during human endothelial cell infection. J Bacteriol. 192(13):3352-67. [PudMed:20418395]
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(111) Mossey P et al (2010). Agrobacterium tumefaciens type IV secretion protein VirB3 is an inner membrane protein and requires VirB4, VirB7, and VirB8 for stabilization. J Bacteriol. 192(11):2830-8. [PudMed:20348257]
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(113) Zola TA et al (2010). Type IV secretion machinery promotes ton-independent intracellular survival of Neisseria gonorrhoeae within cervical epithelial cells. Infect Immun. 78(6):2429-37. [PudMed:20308306]
(114) Saha A et al (2010). Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology. 139(1):239-48. [PudMed:20303353]
(115) Berglund EC et al (2010). Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents. BMC Genomics. 11:152. [PudMed:20202191]
(116) Dalebroux ZD et al (2010). Distinct roles of ppGpp and DksA in Legionella pneumophila differentiation. Mol Microbiol. 76(1):200-19. [PudMed:20199605]
(117) Zhu Y et al (2010). Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci U S A. 107(10):4699-704. [PudMed:20176951]
(118) Cazalet C et al (2010). Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease. PLoS Genet. 6(2):e1000851. [PudMed:20174605]
(119) Niu H et al (2010). Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 6(2):e1000774. [PudMed:20174550]
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(123) Salgado-Pabon W et al (2010). Increased expression of the type IV secretion system in piliated Neisseria gonorrhoeae variants. J Bacteriol. 192(7):1912-20. [PudMed:20139191]
(124) Aguilar J et al (2010). Agrobacterium type IV secretion system and its substrates form helical arrays around the circumference of virulence-induced cells. Proc Natl Acad Sci U S A. 107(8):3758-63. [PudMed:20133577]
(125) Takamatsu R et al (2010). Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis. Biochem J. 427(1):57-67. [PudMed:20102336]
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(127) Sutten EL et al (2010). Anaplasma marginale type IV secretion system proteins VirB2, VirB7, VirB11, and VirD4 are immunogenic components of a protective bacterial membrane vaccine. Infect Immun. 78(3):1314-25. [PudMed:20065028]
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(129) Silveira TN et al (2010). Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis. Infect Immun. 78(3):1403-13. [PudMed:20048047]
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