SecReT6
I. Summary
SecReT6 ID127 experimental
StrainMyxococcus xanthus DK 1622
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_008095
Location5996770..6055445
CommentA deletion covering MXAN_4807-MXAN_4813 shows no growth defects or motility defects; however, the mutant is unable to form mature fruiting bodies (A. Konovalova, unpublished data).
Functioneffector translocation
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number511111111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1MXAN_47935992055..5993263 [+], 1209108762348glycosyltransferase 
2MXAN_47945993317..5993763 [+], 447108763541response regulator 
3MXAN_47955993842..5995125 [+], 1284108761587CBS/transporter associated domain-containing protein 
4MXAN_47965995148..5996323 [-], 1176108759237fibronectin type III 
5MXAN_47985996770..6001965 [-], 5196108757668hypothetical protein 
6MXAN_47996001993..6003840 [-], 1848108763188OmpA domain-containing protein  TagL
7MXAN_48006004071..6006335 [+], 2265108762488Rhs element Vgr family protein  TssI
8MXAN_48016006481..6007098 [+], 618108761628hypothetical protein  TssJ
9MXAN_48026007095..6008462 [+], 1368108763265hypothetical protein  TssK
10MXAN_48036008478..6009194 [+], 717108762493hypothetical protein  TssL
11MXAN_48046009191..6012886 [+], 3696108761699hypothetical protein  TssM
12MXAN_48056012888..6013820 [+], 933108760818hypothetical protein 
13MXAN_48066013836..6015860 [+], 2025108759244hypothetical protein  TssA
14MXAN_48076015943..6016437 [+], 495108759346hypothetical protein  TssB
15MXAN_48086016463..6017947 [+], 1485108763725hypothetical protein  TssC
16MXAN_48096018067..6018558 [+], 492108762846hypothetical protein  TssD
17MXAN_48106018642..6019037 [+], 396108762514hypothetical protein  TssE
18MXAN_48116019075..6020826 [+], 1752108757915hypothetical protein  TssF
19MXAN_48126020862..6021833 [+], 972108762900hypothetical protein  TssG
20MXAN_4813 (clpB)6021917..6024574 [+], 2658108758075ATP-dependent chaperone protein ClpB  TssH
21MXAN_48146024583..6025677 [+], 1095108763839lipoprotein 
22MXAN_48156025827..6026192 [+], 366108763897hypothetical protein 
23MXAN_48166026252..6026809 [+], 558108763140hypothetical protein 
24MXAN_48176026828..6028195 [-], 1368108763963glycosyl hydrolase 
25MXAN_4818 (cysA)6028288..6029355 [-], 1068108761031sulfate ABC transporter ATP-binding protein 
26MXAN_4819 (cysW)6029352..6030179 [-], 828108757696sulfate ABC transporter permease CysW 
27MXAN_4820 (cysT)6030206..6031048 [-], 843108762406sulfate ABC transporter permease CysT 
28MXAN_48216031061..6032071 [-], 1011108760908sulfate ABC transporter periplasmic sulfate-binding protein 
29MXAN_48226032121..6032954 [+], 834108761617hypothetical protein 
30MXAN_48236032464..6035913 [+], 3450108761992ClpB family protein  TssH
31MXAN_48246035918..6039301 [+], 3384108759056ClpA/B family protein  TssH
32MXAN_48256039087..6041597 [+], 2511108759726ClpA/B family protein  TssH
33MXAN_4826 (sodB)6041643..6042224 [-], 582108758510superoxide dismutase, Fe 
34MXAN_48276042250..6042750 [-], 501108757967flavin reductase domain-containing protein 
35MXAN_48286043015..6043107 [+], 93108760170hypothetical protein 
36MXAN_4829 (iorB)6043111..6045372 [-], 2262108757464isoquinoline 1-oxidoreductase subunit beta 
37MXAN_4830 (iorA)6045383..6045844 [-], 462108762706isoquinoline 1-oxidoreductase subunit alpha 
38MXAN_48316045841..6046524 [-], 684108758815lipoprotein 
39MXAN_4832 (clpC)6046572..6049226 [-], 2655108761289ATP-dependent Clp protease, ATP-binding subunit ClpC  TssH
40MXAN_48336049391..6049825 [+], 435108762124hypothetical protein 
41MXAN_48346049632..6050570 [-], 939108759300hypothetical protein 
42MXAN_48356049900..6050466 [+], 567108762583hypothetical protein 
43MXAN_48366050649..6052112 [+], 1464108759194EmrB/QacA family drug resistance transporter 
44MXAN_4837 (celA)6052139..6053617 [-], 1479108762121endoglucanase 
45MXAN_48386053772..6055445 [-], 1674108761318amidase 
46MXAN_48396055602..6057587 [+], 1986108759046ATP-dependent DNA helicase RecQ 
47MXAN_48406057594..6058502 [-], 909108757780pirin 
48MXAN_48416058815..6060029 [-], 1215108757059serine/threonine protein kinase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
MXAN_4809

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1MXAN_48096018067..6018558 [+], 492108762846hypothetical protein MXAN_4809

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Proteins        Genes
N/A
(1) Chang YW et al. (2014). Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography. Nat Methods. 11(7):737-9. [PudMed:24813625] experimental
(2) Konovalova A et al. (2010). Extracellular biology of Myxococcus xanthus. FEMS Microbiol Rev. 34(2):89-106. [PudMed:19895646]
(3) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation