SecReT6
I. Summary
SecReT6 ID195 experimental
StrainAcinetobacter baumannii ATCC 17978
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_009085
Location1506250..1544065
Comment
Functioneffector translocation
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111212112
ComponentTssGTssJTssKTssM
Number1012
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1A1S_12791501546..1502022 [-], 477126641325hypothetical protein 
2A1S_12801502209..1502529 [+], 321126641326transcriptional regulator 
3A1S_12811502900..1504078 [+], 1179126641327TPR domain-containing protein 
4A1S_12821505779..1506096 [+], 318126641328hypothetical protein 
5A1S_12831506250..1507920 [+], 1671126641329putative amidase 
6A1S_12841507992..1508939 [+], 948126641330ABC-type nitrate/sulfonate/bicarbonate transport systems 
7A1S_12851508991..1509707 [-], 717126641331ABC transporter related 
8A1S_12861509872..1510297 [-], 426126641332binding-protein dependent transport system inner membrane protein 
9A1S_12871510374..1510751 [-], 378126641333nitrate/sulfonate/bicarbonate ABC transporter 
10A1S_12881511966..1513246 [+], 1281126641334putative VGR-related protein  TssI
11A1S_12891513051..1514238 [+], 1188126641335putative VGR-related protein  TssI
12A1S_12901514426..1517251 [+], 2826126641336hypothetical protein 
13A1S_12911517370..1518053 [-], 684126641337hypothetical protein 
14A1S_12921519251..1519712 [+], 462126641338putative signal peptide 
15A1S_12931519781..1519930 [+], 150126641339hypothetical protein  TssB
16A1S_12941519993..1520232 [+], 240126641340hypothetical protein  TssB
17A1S_12951520375..1521706 [+], 1332126641341hypothetical protein  TssC
18A1S_12961521756..1522259 [+], 504126641342hypothetical protein  TssD
19A1S_12971522474..1522815 [+], 342126641343hypothetical protein  TssE
20A1S_12981523066..1523623 [+], 558126641344hypothetical protein  TssF
21A1S_12991523946..1524641 [+], 696126641345hypothetical protein  TssF
22A1S_13001524707..1525603 [+], 897126641346hypothetical protein  TssG
23A1S_13011525747..1527012 [+], 1266126641347hypothetical protein 
24A1S_13021527124..1530249 [+], 3126126641348hypothetical protein  TssM
25A1S_13031530300..1530866 [+], 567126641349hypothetical protein  TssM
26A1S_13041531036..1531863 [+], 828126641350hypothetical protein 
27A1S_13051532004..1532633 [+], 630126641351putative outer membrane lipoprotein  TagL
28A1S_13061532650..1532913 [+], 264126641352hypothetical protein  PAAR
29A1S_13071533124..1535814 [+], 2691126641353putative ClpA/B-type chaperone  TssH
30A1S_13081536114..1536935 [+], 822126641354hypothetical protein  TssA
31A1S_13091537150..1538316 [+], 1167126641355hypothetical protein  TssK
32A1S_13101538493..1539140 [+], 648126641356hypothetical protein  TssL
33A1S_13111539763..1540020 [+], 258126641357hypothetical protein 
34A1S_13121540332..1540715 [+], 384126641358hypothetical protein 
35A1S_13131540718..1541494 [-], 777126641359regulatory protein LysR:LysR, substrate-binding 
36A1S_13141541760..1542389 [+], 630126641360ankyrin repeat-containing protein 
37A1S_13151542537..1542887 [+], 351126641361CMP/dCMP deaminase zinc-binding 
38A1S_13161542968..1544065 [+], 1098126641362major facilitator superfamily transporter cyanate permease 
39A1S_13171544460..1545356 [+], 897126641363hypothetical protein 
40A1S_13181545436..1545771 [-], 336126641364GCN5-related N-acetyltransferase 
41A1S_13191546207..1546776 [-], 570126641365hypothetical protein 
42A1S_13201547914..1548219 [+], 306126641366transcriptional regulator SoxR 
43A1S_13211548381..1548815 [+], 435126641367putative hemolysin 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
A1S_1296

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1A1S_12961521756..1522259 [+], 504126641342hypothetical protein A1S_1296
Data from experimental literature

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Proteins        Genes
N/A
Regulatory element identified
H-NS
RegulatorDescriptionReference
H-NS (A1S_0268)RepressorPMID: 23649094

(1) Ruiz FM et al. (2015). Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System. PLoS One. 10(6):e0129691. [PudMed:26079269] experimental
(2) Eijkelkamp BA et al. (2013). H-NS Plays a Role in Expression of Acinetobacter baumannii Virulence Features. Infect Immun. 81(7):2574-83. [PudMed:23649094] experimental
(3) Carruthers MD et al. (2013). Acinetobacter baumannii Utilizes a Type VI Secretion System for Bacterial Competition. PLoS One. 8(3):e59388. [PudMed:23527179] experimental
(4) Weber BS et al. (2013). Genomic and Functional Analysis of the Type VI Secretion System in Acinetobacter. PLoS One. 8(1):e55142. [PudMed:23365692] experimental
 
experimental This literature contains experimental investigation