SecReT6
I. Summary
SecReT6 ID216 insolico
StrainMarinomonas sp. MWYL1
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_009654
Location1318734..1359652
Comment
FunctionN/A
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number131421111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1Mmwyl1_11801314959..1316563 [+], 1605152995209isocitrate lyase 
2Mmwyl1_11811316735..1318540 [+], 1806152995210integral membrane sensor hybrid histidine kinase 
3Mmwyl1_11821318734..1319252 [+], 519152995211hypothetical protein  TssD
4Mmwyl1_11831319447..1321531 [+], 2085152995212Rhs element Vgr protein  TssI
5Mmwyl1_11841321571..1322869 [+], 1299152995213hypothetical protein 
6Mmwyl1_11851322899..1324185 [+], 1287152995214hypothetical protein 
7Mmwyl1_11861324179..1324892 [+], 714152995215hypothetical protein 
8Mmwyl1_11871325046..1325558 [+], 513152995216hypothetical protein 
9Mmwyl1_11881325563..1326324 [+], 762152995217hypothetical protein 
10Mmwyl1_11891326658..1327251 [+], 594152995218VgrG protein  TssI
11Mmwyl1_11901327253..1327777 [+], 525152995219hypothetical protein 
12Mmwyl1_11911327789..1328811 [+], 1023152995220peptidoglycan-binding LysM 
13Mmwyl1_11921328787..1331450 [+], 2664152995221hypothetical protein 
14Mmwyl1_11931331432..1332448 [+], 1017152995222hypothetical protein 
15Mmwyl1_11941333278..1335245 [-], 1968152995223Rhs element Vgr protein  TssI
16Mmwyl1_11951335440..1335958 [-], 519152995224hypothetical protein  TssD
17Mmwyl1_11961336721..1337221 [+], 501152995225hypothetical protein  TssB
18Mmwyl1_11971337275..1338756 [+], 1482152995226hypothetical protein  TssC
19Mmwyl1_11981338761..1339198 [+], 438152995227GPW/gp25 family protein  TssE
20Mmwyl1_11991339201..1340967 [+], 1767152995228hypothetical protein  TssF
21Mmwyl1_12001340931..1341944 [+], 1014152995229hypothetical protein  TssG
22Mmwyl1_12011341947..1343458 [+], 1512152995230FHA domain-containing protein  Fha
23Mmwyl1_12021343448..1343939 [+], 492152995231hypothetical protein  TssJ
24Mmwyl1_12031343942..1345276 [+], 1335152995232hypothetical protein  TssK
25Mmwyl1_12041345279..1346055 [+], 777152995233hypothetical protein  TssL
26Mmwyl1_12051346109..1348730 [+], 2622152995234ATPase  TssH
27Mmwyl1_12061348733..1350283 [+], 1551152995235sigma-54 dependent trancsriptional regulator  VasH
28Mmwyl1_12071350276..1350902 [+], 627152995236hypothetical protein 
29Mmwyl1_12081350913..1352322 [+], 1410152995237ImpA domain-containing protein  TssA
30Mmwyl1_12091352337..1355885 [+], 3549152995238ImcF domain-containing protein  TssM
31Mmwyl1_12101355932..1356609 [+], 678152995239hypothetical protein  TssA
32Mmwyl1_12111356826..1357344 [+], 519152995240hypothetical protein  TssD
33Mmwyl1_12121357553..1359652 [+], 2100152995241Rhs element Vgr protein  TssI
34Mmwyl1_12131359649..1360575 [+], 927152995242hypothetical protein 
35Mmwyl1_12141360572..1363964 [+], 3393152995243peptidoglycan-binding LysM 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
VCA0017 , VCA0017, VCA0017

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1Mmwyl1_11821318734..1319252 [+], 519152995211hypothetical protein VCA0017
2Mmwyl1_11951335440..1335958 [-], 519152995224hypothetical protein VCA0017
3Mmwyl1_12111356826..1357344 [+], 519152995240hypothetical protein VCA0017

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Proteins        Genes
N/A
Regulatory element identified
VasH
RegulatorDescriptionReference
VasH (Mmwyl1_1206)ActivatorPMID: 21378190

(1) Bernard CS et al. (2011). Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol. 193(9):2158-67. [PudMed:21378190] experimental
 
experimental This literature contains experimental investigation