SecReT6
I. Summary
SecReT6 ID303 experimental
StrainSalmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_011274
Location1114451..1137704
CommentColonisation of chicken ileum, caeca, liver and spleen
Functionanti-eukaryotic
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121121101
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SG10231110982..1111287 [-], 306205352283hypothetical protein 
2SG10251112125..1112583 [-], 459205352284hypothetical protein 
3SG10261112707..1113078 [-], 372205352285hypothetical protein 
4SG10281113546..1114436 [-], 891205352286DNA-binding protein 
5SG10291114451..1114930 [-], 480205352287hypothetical protein  TssD
6SG10301114918..1116549 [-], 1632205352288hypothetical protein  TssA
7SG10311116332..1119853 [-], 3522205352289hypothetical protein  TssM
8SG10321119872..1121167 [-], 1296205352290hypothetical protein  TssA
9SG10331121286..1122023 [-], 738205352291hypothetical protein 
10SG10341122020..1124683 [-], 2664205352292clpB-protease  TssH
11SG10351124696..1125454 [-], 759205352293hypothetical protein  TssL
12SG10361125459..1126790 [-], 1332205352294hypothetical protein  TssK
13SG10371126793..1127326 [-], 534205352295lipoprotein  TssJ
14SG10381127323..1128621 [-], 1299205352296hypothetical protein  Fha
15SG10391128634..1129728 [-], 1095205352297hypothetical protein  TssG
16SG10401129686..1131599 [-], 1914205352298hypothetical protein  TssF
17SG10411131957..1133429 [-], 1473205352299hypothetical protein  TssC
18SG10421133720..1134232 [-], 513205352300hypothetical protein  TssB
19SG10431134853..1135371 [+], 519205352301hypothetical protein  TssD
20SG10441135593..1137704 [+], 2112205352302RHS family protein  TssI
21SG10451137806..1141114 [+], 3309205352303RHS family protein  PAAR
22SG10471142197..1142601 [+], 405205352304hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
ECA4275 , STY2606, Hcp

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SG10431134853..1135371 [+], 519205352301hypothetical protein ECA4275
2SG24052471848..2472216 [+], 369205353488hypothetical protein STY2606
3SG30253156314..3156799 [-], 486205354051hypothetical protein Hcp

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Proteins        Genes

Homology Immunity protein list
STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SG24062472216..2472734 [+], 519205353489lipoprotein STY2607

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Proteins        Genes
(1) Pezoa D et al. (2013). The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken. PLoS One. 8(5):e63917. [PudMed:23691117] experimental
(2) Blondel CJ et al. (2013). The Type VI Secretion System encoded in SPI-19 is required for Salmonella Gallinarum survival within infected macrophages. Infect Immun. 81(4):1207-20. [PudMed:23357385] experimental
(3) Silva CA et al. (2012). Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 80(2):839-49. [PudMed:22083712] experimental
(4) Blondel CJ et al. (2010). Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 5(7):e11724. [PudMed:20661437] experimental
(5) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904] in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation