SecReT6
I. Summary
SecReT6 ID335 insolico
StrainVibrio cholerae M66-2
Repliconchromosome II [Browse all T6SS(s) in this replicon]
AccessionNC_012580
Location116837..140625
Comment
FunctionN/A
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number101121111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1VCM66_A0102 (rluA-2)112682..114361 [-], 1680227811730ribosomal large subunit pseudouridine synthase A 
2VCM66_A0103115133..115417 [+], 285227811731hypothetical protein  PAAR
3VCM66_A0104115362..116405 [+], 1044227811732hypothetical protein 
4VCM66_A0105116837..117343 [+], 507227811733hypothetical protein  TssB
5VCM66_A0106117384..118862 [+], 1479227811734hypothetical protein  TssC
6VCM66_A0107118865..119302 [+], 438227811735hypothetical protein  TssE
7VCM66_A0108119308..121077 [+], 1770227811736hypothetical protein  TssF
8VCM66_A0109121041..122057 [+], 1017227811737hypothetical protein  TssG
9VCM66_A0110122060..123547 [+], 1488227811738hypothetical protein  Fha
10VCM66_A0111123550..124026 [+], 477227811739hypothetical protein  TssJ
11VCM66_A0112124033..125367 [+], 1335227811740hypothetical protein  TssK
12VCM66_A0113125370..126143 [+], 774227811741hypothetical protein  TssL
13VCM66_A0114 (clpB-2)126169..128778 [+], 2610227811742clpB protein  TssH
14VCM66_A0115128781..130373 [+], 1593227811743sigma-54 dependent transcriptional regulator  VasH
15VCM66_A0116130343..131026 [+], 684227811744hypothetical protein  VCA0118
16VCM66_A0117131036..132445 [+], 1410227811745hypothetical protein  TssA
17VCM66_A0118132461..136006 [+], 3546227811746IcmF-related protein  TssM
18VCM66_A0119136054..137319 [+], 1266227811747hypothetical protein  TssA
19VCM66_A0120137370..137612 [+], 243227811748hypothetical protein 
20VCM66_A0121 (vgrG-3)137572..140625 [+], 3054227811749vgrG protein  TssI
21VCM66_A0122140622..140990 [+], 369227811750hypothetical protein  TsiV3 (i)
22VCM66_A0123141138..141398 [-], 261227811751hypothetical protein 
23VCM66_A0124141373..141582 [+], 210227811752hypothetical protein 
24VCM66_A0125 (rbsD)141631..142101 [+], 471227811753D-ribose pyranase 
25VCM66_A0126 (rbsA)142128..143630 [+], 1503227811754D-ribose transporter ATP binding protein 
26VCM66_A0127 (rbsC)143627..144628 [+], 1002227811755ribose ABC transporter permease protein 
27VCM66_A0128 (rbsB)144683..145567 [+], 885227811756D-ribose transporter subunit RbsB 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
ABG57132 , VC1416, VC1418, VCA0017, VCA0018, VCA0020, VCA0118, VCA0123, VCA0285

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VCM66_1370(hcp-1)1467074..1467592 [+], 519227081586hcp protein ABG57132
2VCM66_1371(vgrG-1)1467720..1471211 [+], 3492227081587vgrG protein VC1416
3VCM66_13731472053..1473978 [+], 1926227081589hypothetical protein VC1418
4VCM66_A0016(hcp-2)19766..20284 [+], 519227811648hcp protein VCA0017
5VCM66_A0017(vgrG-2)20412..22496 [+], 2085227811649vgrG protein VCA0018
6VCM66_A001923380..26646 [+], 3267227811651hypothetical protein VCA0020
7VCM66_A0116130343..131026 [+], 684227811744hypothetical protein VCA0118
8VCM66_A0121(vgrG-3)137572..140625 [+], 3054227811749vgrG protein VCA0123
9VCM66_A0284306399..307070 [+], 672227811908hypothetical protein VCA0285

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Proteins        Genes

Homology Immunity protein list
VC1419, VCA0021, VCA0124, VCA0286

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VCM66_13741473975..1474718 [+], 744227081590hypothetical protein VC1419
2VCM66_A002026647..27375 [+], 729227811652hypothetical protein VCA0021
3VCM66_A0122140622..140990 [+], 369227811750hypothetical protein VCA0124
4VCM66_A0285307072..307422 [+], 351227811909hypothetical protein VCA0286

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Proteins        Genes
N/A