SecReT6
I. Summary
SecReT6 ID346 experimental
StrainEdwardsiella ictaluri 93-146
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_012779
Location2631752..2651730
Comment
Functioneffector translocation;virulence
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111111111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1NT01EI_27332627075..2628169 [+], 1095238920621hypothetical protein 
2NT01EI_27342628451..2628564 [-], 114238920622hypothetical protein 
3NT01EI_27352628981..2630237 [-], 1257238920623mutator family transposase 
4NT01EI_27362630260..2630574 [-], 315238920624hypothetical protein 
5NT01EI_27372631752..2632264 [+], 513238920625hypothetical protein  TssB
6NT01EI_27382632264..2633751 [+], 1488238920626hypothetical protein  TssC
7NT01EI_27392633938..2634312 [+], 375238920627hypothetical protein  TssD
8NT01EI_27402634442..2635653 [+], 1212238920628hypothetical protein 
9NT01EI_27412635662..2636138 [+], 477238920629hypothetical protein  TssE
10NT01EI_27422636142..2637983 [+], 1842238920630hypothetical protein  TssF
11NT01EI_27432637980..2639005 [+], 1026238920631hypothetical protein  TssG
12NT01EI_27442639125..2641746 [+], 2622238920632type VI secretion ATPase, ClpV1 family  TssH
13NT01EI_27452641737..2643722 [+], 1986238920633hypothetical protein  TssI
14NT01EI_27462643817..2644119 [+], 303238920634hypothetical protein  PAAR
15NT01EI_27472644133..2645203 [+], 1071238920635hypothetical protein  TssA
16NT01EI_27482645190..2645819 [+], 630238920636hypothetical protein  TssJ
17NT01EI_27492645916..2647304 [+], 1389238920637hypothetical protein  TssK
18NT01EI_27502647469..2647951 [+], 483238920638hypothetical protein  TssL
19NT01EI_27512647948..2651730 [+], 3783238920639hypothetical protein  TssM
20NT01EI_27522651927..2652064 [+], 138238920640hypothetical protein 
21NT01EI_2753 (mepA)2652351..2653175 [-], 825238920641penicillin-insensitive murein endopeptidase 
22NT01EI_27542653189..2654274 [-], 1086238920642chorismate synthase 
23NT01EI_27552654361..2655293 [-], 933238920643N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 
24NT01EI_27562655468..2656049 [+], 582238920644hypothetical protein 
25NT01EI_27572656100..2656576 [-], 477238920645phosphohistidine phosphatase SixA 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
EvpC , EvpI

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1NT01EI_27392633938..2634312 [+], 375238920627hypothetical protein EvpC
2NT01EI_27452641737..2643722 [+], 1986238920633hypothetical protein EvpI
Data from experimental literature

Download FASTA format files
Proteins        Genes
N/A
Regulatory element identified
EsrC
RegulatorDescriptionReference
EsrCActivatorPMID: 21551284

EsrB
RegulatorDescriptionReference
EsrBIndirect activatorPMID: 21551284

(1) Rogge ML et al. (2011). Regulation of the Edwardsiella ictaluri type III secretion system by pH and phosphate concentration through EsrA, EsrB, and EsrC. Appl Environ Microbiol. 77(13):4293-302. [PudMed:21551284] experimental
 
experimental This literature contains experimental investigation