SecReT6
I. Summary
SecReT6 ID47 experimental
StrainHelicobacter hepaticus ATCC 51449
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_004917
Location227242..253067
CommentAnti-inflammatory response in cultured intestinal epithelial cells and limitation of intestinal colonisation in mice (and perhaps therefore promotion of a tolerant, balanced relationship with host)
Functionanti-eukaryotic; effector translocation;virulence
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number011201101
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1HH0233223218..224198 [-], 98132265732hypothetical protein 
2HH0234224333..225118 [-], 78632265733hypothetical protein 
3HH0235225105..226610 [-], 150632265734hypothetical protein 
4HH0236226607..227245 [-], 63932265735hypothetical protein 
5HH0237227242..228036 [-], 79532265736hypothetical protein  TssI
6HH0238228126..228986 [-], 86132265737DNA adenine methylase 
7HH0239228983..229768 [-], 78632265738type II restriction endonuclease 
8HH0240229864..230250 [-], 38732265739hypothetical protein 
9HH0241230306..231583 [-], 127832265740hypothetical protein 
10HH0242231618..234416 [-], 279932265741hypothetical protein  TssI
11HH0243234543..235052 [-], 51032265742hypothetical protein  TssD
12HH0244235149..236144 [-], 99632265743hypothetical protein  TssG
13HH0245236141..237856 [-], 171632265744hypothetical protein  TssF
14HH0246237926..238315 [-], 39032265745hypothetical protein 
15HH0247238319..239791 [-], 147332265746hypothetical protein  TssC
16HH0248239839..240336 [-], 49832265747hypothetical protein  TssB
17HH0249240524..241060 [+], 53732265748hypothetical protein  TssJ
18HH0250241053..242432 [+], 138032265749hypothetical protein  TssK
19HH0251242444..243232 [+], 78932265750hypothetical protein  TssL
20HH0252243237..246791 [+], 355532265751hypothetical protein  TssM
21HH0253246801..247781 [+], 98132265752hypothetical protein  Fha
22HH0254247872..249140 [-], 126932265753hypothetical protein 
23HH0255249168..253067 [-], 390032265754hypothetical protein 
24HH0256253173..254729 [-], 155732265755hypothetical protein 
25HH0257254722..256059 [-], 133832265756hypothetical protein 
26HH0258256069..256437 [-], 36932265757hypothetical protein 
27HH0259256448..257131 [-], 68432265758hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
HH0242 , HH0243, HH0242

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1HH0242231618..234416 [-], 279932265741hypothetical protein HH0242
2HH0243234543..235052 [-], 51032265742hypothetical protein HH0243
3HH0291283450..284859 [-], 141032265790hypothetical protein HH0242
Data from experimental literature

Download FASTA format files
Proteins        Genes
N/A
(1) Bartonickova L et al. (2013). Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential. Cell Microbiol. 15(6):992-1011. [PudMed:23278999] experimental
(2) Chow J et al. (2010). A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe. 7(4):265-76. [PudMed:20413095] experimental
(3) Ge Z et al. (2008). Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. Microbes Infect. 10(7):726-33. [PudMed:18538610] experimental
 
experimental This literature contains experimental investigation