SecReT6
I. Summary
SecReT6 ID535 experimental
StrainSalmonella enterica subsp. enterica serovar Typhimurium str. SL1344
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_016810
Location304656..332038
CommentContribution to pathogenesis and systemic dissemination in a mouse model of typhoid, intracellular replication in macrophages
Functionanti-eukaryotic; virulence
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121111111
ComponentTssGTssJTssKTssM
Number1111
Click the above image to have a larger view
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SL1344_0255 (mltD)299914..301281 [-], 1368378698233membrane-bound lytic murein transglycosylase d 
2SL1344_0256 (gloB)301353..302108 [-], 756378698234hydroxyacylglutathione hydrolase 
3SL1344_0257302143..302865 [+], 723378698235hypothetical protein 
4SL1344_0258 (rnhA)302862..303329 [-], 468378698236ribonuclease H 
5SL1344_0259 (dnaQ)303393..304124 [+], 732378698237DNA polymerase III subunit epsilon 
6SL1344_0260 (sciA)304656..305711 [-], 1056378698238hypothetical protein  TssA
7SL1344_0261 (sciB)305722..306717 [-], 996378698239hypothetical protein  TssG
8SL1344_0262 (sciC)306714..308597 [-], 1884378698240hypothetical protein  TssF
9SL1344_0263 (sciD)308613..309107 [-], 495378698241hypothetical protein  TssE
10SL1344_0264 (sciE)309104..309928 [-], 825378698242hypothetical protein  TagJ
11SL1344_0265 (sciF)309915..310817 [-], 903378698243hypothetical protein 
12SL1344_0266 (sciG)311185..313824 [+], 2640378698244hypothetical protein  TssH
13SL1344_0267 (sciH)313924..314466 [+], 543378698245hypothetical protein  TssB
14SL1344_0268 (sciI)314490..315983 [+], 1494378698246hypothetical protein  TssC
15SL1344_0270 (sciJ)316169..316615 [+], 447378698247hypothetical protein 
16SL1344_0271 (sciK)316869..317354 [+], 486378698248hypothetical protein  TssD
17SL1344_0272317659..318144 [+], 486378698249hypothetical protein  STM0277 (e)
18SL1344_0273318129..318512 [+], 384378698250hypothetical protein  STM0278 (i)
19SL1344_0274 (sciK1)318655..319140 [+], 486378698251hypothetical protein  TssD
20SL1344_0275 (sciN)319207..319743 [+], 537378698252lipoprotein  TssJ
21SL1344_0276 (sciO)319747..321090 [+], 1344378698253hypothetical protein  TssK
22SL1344_0277 (sciP)321087..322391 [+], 1305378698254hypothetical protein  TssL
23SL1344_0278 (sciQ)322396..323169 [+], 774378698255putative membrane protein, virulence associated protein 
24SL1344_0279 (sciR)323372..323803 [+], 432378698256hypothetical protein 
25SL1344_0280 (sciS)323837..327706 [+], 3870378698257IcmF-related integral membrane ATP-binding protein, virulence associated protein  TssM
26SL1344_0281 (sciT)327706..328494 [+], 789378698258hypothetical protein 
27SL1344_0282 (sciU)328491..328907 [+], 417378698259secreted protein 
28SL1344_0283 (sciV)328931..329452 [+], 522378698260hypothetical protein 
29SL1344_0284 (vrgS)329849..332038 [+], 2190378698261Type VI secretion protein  TssI
30SL1344_0285 (sciW)332062..332508 [+], 447378698262hypothetical protein 
31SL1344_0286332521..336123 [+], 3603378698263Rhs family protein  PAAR
32SL1344_0286A336117..336380 [+], 264378698264hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
SciK , STM0277, SciK, STY2606, Hcp

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SL1344_0271(sciK)316869..317354 [+], 486378698248hypothetical protein SciK
2SL1344_0272317659..318144 [+], 486378698249hypothetical protein STM0277
3SL1344_0274(sciK1)318655..319140 [+], 486378698251hypothetical protein SciK
4SL1344_23442484631..2484999 [+], 369378700285hypothetical protein STY2606
5SL1344_31053311675..3312160 [-], 486378701037hypothetical protein Hcp

Download FASTA format files
Proteins        Genes

Homology Immunity protein list
STM0278, STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SL1344_0273318129..318512 [+], 384378698250hypothetical protein STM0278
2SL1344_23452484999..2485517 [+], 519378700286putative lipoprotein STY2607

Download FASTA format files
Proteins        Genes
(1) Mulder DT et al. (2012). Type VI secretion system-associated gene clusters contribute to pathogenesis of Salmonella enterica serovar Typhimurium. Infect Immun. 80(6):1996-2007. [PudMed:22493086] experimental
 
experimental This literature contains experimental investigation