SecReT6
I. Summary
SecReT6 ID613 insolico
StrainPseudomonas aeruginosa M18
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_017548
Location3757284..3776259
Comment
FunctionN/A
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number101011111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1PAM18_33713752833..3753153 [+], 321386059434hypothetical protein 
2PAM18_33723753210..3753767 [+], 558386059435hypothetical protein 
3PAM18_3373 (folE)3753845..3754390 [+], 546386059436GTP cyclohydrolase I 
4PAM18_33743754455..3754916 [-], 462386059437hypothetical protein 
5PAM18_33753755162..3755542 [+], 381386059438hypothetical protein 
6PAM18_3376 (stk1)3755570..3756559 [-], 990386059439serine-threonine kinase Stk1  Stk1
7PAM18_3377 (stp1)3756556..3757284 [-], 729386059440serine/threonine phosphoprotein phosphatase Stp1  Stp1
8PAM18_33783757284..3760811 [-], 3528386059441hypothetical protein  TssM
9PAM18_33793760827..3761696 [-], 870386059442putative outer membrane protein  TssL
10PAM18_33803761699..3763030 [-], 1332386059443hypothetical protein  TssK
11PAM18_33813763027..3763542 [-], 516386059444putative lipoprotein  TssJ
12PAM18_33823763539..3764732 [-], 1194386059445hypothetical protein  Fha
13PAM18_33833764979..3766490 [-], 1512386059446putative transcriptional regulator  Sfa2
14PAM18_33843766501..3769128 [-], 2628386059447putative ClpA/B-type protease  TssH
15PAM18_33853769141..3770148 [-], 1008386059448hypothetical protein  TssG
16PAM18_33863770112..3771899 [-], 1788386059449hypothetical protein  TssF
17PAM18_33873772237..3772644 [-], 408386059450hypothetical protein  TssE
18PAM18_33883772657..3774132 [-], 1476386059451hypothetical protein  TssC
19PAM18_33893774161..3774667 [-], 507386059452hypothetical protein  TssB
20PAM18_33903774703..3776259 [-], 1557386059453hypothetical protein  TssA
21PAM18_33913777431..3778033 [-], 603386059454putative glutathione S-transferase 
22PAM18_33923778089..3779255 [-], 1167386059455putative aminotransferase 
23PAM18_33933779337..3779813 [+], 477386059456putative transcriptional regulator 
24PAM18_33943779863..3780498 [-], 636386059457hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
PSPTO_5435 , PSPTO_5435, PSPTO_5435

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1PAM18_0258(hcpB)289792..290310 [-], 519386056327secreted protein Hcp PSPTO_5435
2PAM18_3619(hcpB)4022380..4022898 [+], 519386059680secreted protein Hcp PSPTO_5435
3PAM18_5387(hcpB)5987719..5988237 [-], 519386061444secreted protein Hcp PSPTO_5435

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Proteins        Genes
N/A
Regulatory element identified
GacA
RegulatorDescriptionReference
GacA (PAM18_2407)ActivatorPMID: 23708134

(1) Wei X et al. (2013). Global control of GacA on secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. J Bacteriol. 195(15):3387-400. [PudMed:23708134] experimental
 
experimental This literature contains experimental investigation