SecReT6
I. Summary
SecReT6 ID763 insolico
StrainSalmonella enterica subsp. enterica serovar Typhi str. Ty21a
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_021176
Location2650288..2695793
Comment
FunctionN/A
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number211101011
ComponentTssGTssJTssKTssM
Number1112
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1TY21A_130402645735..2649799 [-], 4065488655060Rhs-family protein  PAAR
2TY21A_130452649818..2650264 [-], 447488655061hypothetical protein 
3TY21A_130502650288..2652477 [-], 2190488655062Rhs-family protein  TssI
4TY21A_130552652840..2652947 [-], 108488655063hypothetical protein 
5TY21A_130602652955..2653392 [-], 438488655064conserved hypothetical pathogenicity island protein 
6TY21A_130652653419..2653805 [-], 387488655065putative secreted protein 
7TY21A_130702653963..2654424 [-], 462488655066hypothetical protein 
8TY21A_130752654409..2654879 [-], 471488655067hypothetical protein 
9TY21A_130802654922..2655689 [-], 768488655068putative cytoplasmic protein 
10TY21A_130852655689..2657677 [-], 1989488655069type VI secretion protein IcmF  TssM
11TY21A_130902657574..2659550 [-], 1977488655070putative inner membrane protein  TssM
12TY21A_130952659787..2660281 [-], 495488655071hypothetical protein 
13TY21A_131002660313..2661062 [-], 750488655072hypothetical protein 
14TY21A_131052661067..2662368 [-], 1302488655073hypothetical protein  TssL
15TY21A_131102662365..2663708 [-], 1344488655074type VI secretion protein  TssK
16TY21A_131152663712..2664248 [-], 537488655075lipoprotein  TssJ
17TY21A_131202664315..2664800 [-], 486488655076hemolysin-coregulated protein  TssD
18TY21A_131252665037..2665462 [-], 426488655077hypothetical protein  STY0301 (i)
19TY21A_131302665434..2665835 [-], 402488655078hypothetical protein  STY0300 (e)
20TY21A_131452667420..2667962 [-], 543488655079type VI secretion protein, VC_A0107 family  TssB
21TY21A_131502668026..2668316 [-], 291488655080hypothetical protein 
22TY21A_131552668402..2671065 [-], 2664488655081ClpB-like protein  TssH
23TY21A_131602671433..2672335 [+], 903488655082hypothetical protein 
24TY21A_131652672322..2673146 [+], 825488655083hypothetical protein  TagJ
25TY21A_131702673143..2673637 [+], 495488655084putative cytoplasmic protein  TssE
26TY21A_131752673653..2675536 [+], 1884488655085hypothetical protein  TssF
27TY21A_131802675533..2676528 [+], 996488655086hypothetical protein  TssG
28TY21A_131952678123..2678863 [-], 741488655087DNA polymerase III subunit epsilon 
29TY21A_13200 (rnhA)2678918..2679385 [+], 468488655088ribonuclease H 
30TY21A_132052679382..2680104 [-], 723488655089putative methyltransferase 
31TY21A_132102680139..2680894 [+], 756488655090hydroxyacylglutathione hydrolase 
32TY21A_13215 (mltD)2681113..2682333 [+], 1221488655091membrane-bound lytic murein transglycosylase D 
33TY21A_132202682389..2683159 [-], 771488655092putative methyltransferase in menaquinone/biotin biosynthesis 
34TY21A_132252683237..2684037 [-], 801488655093hypothetical protein 
35TY21A_132302684169..2685344 [-], 1176488655094putative drug efflux protein 
36TY21A_132352685449..2686363 [+], 915488655095transcriptional regulator 
37TY21A_13240 (dkgB)2686384..2687187 [-], 8044886550962,5-diketo-D-gluconate reductase B 
38TY21A_132452693220..2695793 [-], 2574488655097protein disaggregation chaperone  TssH
39TY21A_132502695923..2696654 [-], 732488655098hypothetical protein 
40TY21A_13255 (rluD)2696651..2697631 [-], 98148865509923S rRNA pseudouridine synthase D 
41TY21A_132602697763..2698500 [+], 738488655100outer membrane protein assembly complex subunit YfiO 
42TY21A_132652698772..2699110 [+], 339488655101translation inhibitor protein RaiA 
43TY21A_13270 (pheA)2699361..2700521 [+], 1161488655102bifunctional chorismate mutase/prephenate dehydratase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
STY2606 , SciK, STY0300, Hcp

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1TY21A_02490562410..562778 [-], 369488653037hypothetical protein STY2606
2TY21A_131202664315..2664800 [-], 486488655076hemolysin-coregulated protein SciK
3TY21A_131302665434..2665835 [-], 402488655078hypothetical protein STY0300
4TY21A_154153132317..3132802 [-], 486488655514putative cytoplasmic protein Hcp

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Proteins        Genes

Homology Immunity protein list
STY2607, STY0301

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1TY21A_02485561892..562410 [-], 519488653036putative lipoprotein STY2607
2TY21A_131252665037..2665462 [-], 426488655077hypothetical protein STY0301

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Proteins        Genes
N/A