 SecReT6 ID | 787  |
| Strain | Escherichia coli RS218 |
| Replicon | chromosome [Browse all T6SS(s) in this replicon] |
| Accession | JN837480 |
| Location | 1..23615 |
| Comment | T6SS-associated Hcp family proteins are likely to contribute to the pathogenesis of E. coli meningitis; Adhesion to and invasion of human brain microvascular endothelial cells. |
| Function | anti-eukaryotic;effector translocation;adherence |
| T6SS Type | Type i; subtype i1 |
| Experimental investigation has been performed on this T6SS. |
| Component | TssH | TssD | TssL | TssI | TssA | TssB | TssC | TssE | TssF |
| Number | 3 | 2 | 1 | 1 | 3 | 1 | 2 | 1 | 1 |
| Component | TssG | TssJ | TssK | TssM |
| Number | 1 | 1 | 1 | 2 |
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| III. genome coordinates of the T6SS gene cluster |
| # | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | Note |
| 1 | EvfA (evfA) | 471..950 [-], 480 | 356875268 | EvfA | TssD |
| 2 | EvfB (evfB) | 968..2326 [-], 1359 | 356875269 | EvfB | TssA |
| 3 | EvfC (evfC) | 2337..5354 [-], 3018 | 356875270 | EvfC | TssM |
| 4 | EvfD (evfD) | 5386..5865 [-], 480 | 356875272 | EvfD | TssM |
| 5 | EvfF (evfF) | 5885..7327 [-], 1443 | 356875273 | EvfF | TssA |
| 6 | EvfE (evfE) | 5885..6316 [-], 432 | 356875271 | EvfE | TssA |
| 7 | EvfG (evfG) | 7332..7979 [-], 648 | 356875274 | EvfG | |
| 8 | EvfH (evfH) | 8072..9130 [-], 1059 | 356875275 | EvfH | TssH |
| 9 | EvfI (evfI) | 9085..9714 [-], 630 | 356875276 | EvfI | TssH |
| 10 | EvfJ (evfJ) | 9686..10834 [-], 1149 | 356875277 | EvfJ | TssH |
| 11 | EvfK (evfK) | 10844..11608 [-], 765 | 356875278 | EvfK | TssL |
| 12 | EvfL (evfL) | 11613..12959 [-], 1347 | 356875279 | EvfL | TssK |
| 13 | EvfM (evfM) | 12962..13486 [-], 525 | 356875280 | EvfM | TssJ |
14 | EvfN (evfN) | 13483..14091 [-], 609 | 356875281 | EvfN | Fha |
15 | EvfO (evfO) | 13991..14764 [-], 774 | 356875282 | EvfO | Fha |
| 16 | EvfP (evfP) | 14781..15830 [-], 1050 | 356875283 | EvfP | TssG |
| 17 | EvfQ (evfQ) | 15794..17635 [-], 1842 | 356875284 | EvfQ | TssF |
| 18 | EvfR (evfR) | 17641..18066 [-], 426 | 356875285 | EvfR | TssE |
| 19 | EvfS (evfS) | 18071..19126 [-], 1056 | 356875286 | EvfS | TssC |
| 20 | EvfT (evfT) | 19089..19556 [-], 468 | 356875287 | EvfT | TssC |
| 21 | EvfU (evfU) | 19579..20082 [-], 504 | 356875288 | EvfU | TssB |
| 22 | EvfV (evfV) | 20788..21306 [+], 519 | 356875290 | EvfV | TssD |
| 23 | EvfW (evfW) | 21527..23509 [+], 1983 | 356875289 | EvfW | TssI |
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Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein
V. Investigation of the genomic context of the T6SS gene cluster. 