I. Summary
SecReT6 ID820 insolico
StrainSalmonella enterica subsp. enterica serovar Heidelberg str. 41578
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SEEH1578_10390 (mltD)2100603..2101970 [-], 1368525816127membrane-bound lytic murein transglycosylase D 
2SEEH1578_103952102042..2102797 [-], 756525816128hydroxyacylglutathione hydrolase 
3SEEH1578_104002102832..2103554 [+], 723525816129hypothetical protein 
4SEEH1578_10405 (rnhA)2103551..2104018 [-], 468525816130ribonuclease H 
5SEEH1578_104102104082..2104813 [+], 732525816131DNA polymerase III subunit epsilon 
6SEEH1578_104152105147..2105254 [+], 108525816132hypothetical protein 
7SEEH1578_104202105345..2106400 [-], 1056525816133putative cytoplasmic protein  TssA
8SEEH1578_104252106411..2107406 [-], 996525816134type VI secretion protein  TssG
9SEEH1578_104302107403..2109286 [-], 1884525816135Protein ImpG/VasA  TssF
10SEEH1578_104352109302..2109796 [-], 495525816136hypothetical protein  TssE
11SEEH1578_104402109793..2110617 [-], 825525816137Protein of avirulence locus ImpE  TagJ
12SEEH1578_104452110604..2111506 [-], 903525816138hypothetical protein 
13SEEH1578_104502111874..2114513 [+], 2640525816139ClpB protein  TssH
14SEEH1578_104552114613..2115155 [+], 543525816140hypothetical protein  TssB
15SEEH1578_104602115179..2116687 [+], 1509525816141Type VI protein secretion system  TssC
16SEEH1578_104652116740..2117141 [+], 402525816142hypothetical protein  STY0300 (e)
17SEEH1578_104702117113..2117538 [+], 426525816143hypothetical protein  STY0301 (i)
18SEEH1578_104752117775..2118260 [+], 486525816144Protein hcp1  TssD
19SEEH1578_104802118563..2119048 [+], 486525816145Type VI secretion system-associated protein  STM0277 (e)
20SEEH1578_104852119045..2119416 [+], 372525816146putative periplasmic protein  STM0278 (i)
21SEEH1578_104902119559..2120044 [+], 486525816147Protein hcp1  TssD
22SEEH1578_104952120112..2120648 [+], 537525816148hypothetical protein  TssJ
23SEEH1578_105002120652..2121995 [+], 1344525816149type VI secretion protein  TssK
24SEEH1578_105052121992..2123296 [+], 1305525816150hypothetical protein  TssL
25SEEH1578_105102123301..2124074 [+], 774525816151hypothetical protein 
26SEEH1578_105152124352..2124708 [+], 357525816152putative shiga-like toxin A subunit 
27SEEH1578_105202124742..2128611 [+], 3870525816153Type VI secretion protein IcmF  TssM
28SEEH1578_105252128611..2129378 [+], 768525816154type VI secretion system-associated protein 
29SEEH1578_105302129421..2129891 [+], 471525816155hypothetical protein 
30SEEH1578_105352129876..2130337 [+], 462525816156hypothetical protein 
31SEEH1578_105402130346..2130468 [+], 123525816157hypothetical protein 
32SEEH1578_105452130465..2130881 [+], 417525816158hypothetical protein 
33SEEH1578_105502130908..2131426 [+], 519525816159SPI-6 associated protein 
34SEEH1578_105552131823..2134054 [+], 2232525816160VgrG protein  TssI
35SEEH1578_105602134114..2134572 [+], 459525816161hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
ROD_34191 , STY0300, EvpC, STM0277, EvpC, STY2606

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SEEH1578_01785237043..237528 [-], 486525814414hypothetical protein ROD_34191
2SEEH1578_104652116740..2117141 [+], 402525816142hypothetical protein STY0300
3SEEH1578_104752117775..2118260 [+], 486525816144Protein hcp1 EvpC
4SEEH1578_104802118563..2119048 [+], 486525816145Type VI secretion system-associated protein STM0277
5SEEH1578_104902119559..2120044 [+], 486525816147Protein hcp1 EvpC
6SEEH1578_211504280206..4280574 [+], 369525818263NlpC/P60 enzyme STY2606

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Proteins        Genes

Homology Immunity protein list
STY0301, STM0278, STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SEEH1578_104702117113..2117538 [+], 426525816143hypothetical protein STY0301
2SEEH1578_104852119045..2119416 [+], 372525816146putative periplasmic protein STM0278
3SEEH1578_211554280574..4281092 [+], 519525818264putative lipoprotein STY2607

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Proteins        Genes