SecReT6
SecReT6 ID904 experimental
StrainEscherichia coli strain TW-XM
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionKF678349
Location1..29754
CommentT6SS1-associated mutants presented diminished adherence and invasion of several host cells cultured in vitro, decreased pathogenicity in duck and mouse infection models in vivo, and decreased biofilm formation and bacterial competitive advantage.
Functionanti-eukaryotic; effector translocation
T6SS TypeType i; subtype i2
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111121111
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1xmoA (xmoA)1..501 [+], 501611963679XmoA  TssB
2xmoB (xmoB)554..2098 [+], 1545611963680XmoB  TssC
3xmoC (xmoC)2116..3453 [+], 1338611963681XmoC  TssK
4xmoD (xmoD)3450..4115 [+], 666611963682XmoD  TssL
5xmoE (xmoE)4167..5780 [+], 1614611963683XmoE  TagL
6xmoF (xmoF)5838..6329 [+], 492611963684Hcp-like protein  TssD
7xmoG (xmoG)6521..9166 [+], 2646611963685putative ATP-dependent Clp protease  TssH
8xmoH (xmoH)9178..11658 [+], 2481611963686XmoH  TssI
9xmoI (xmoI)11678..13447 [+], 1770611963687hypothetical protein  Tle4 (e)
10xmoJ (xmoJ)13422..14132 [+], 711611963688hypothetical protein  Tli4 (i)
11xmoK (xmoK)14223..14516 [+], 294611963689hypothetical protein 
12xmoL (xmoL)14905..15240 [+], 336611963690hypothetical protein  PAAR
13xmoM (xmoM)15161..16378 [+], 1218611963691hypothetical protein 
14xmoN (xmoN)16388..19741 [+], 3354611963692IcmF-like protein  TssM
15xmoO (xmoO)19707..21344 [+], 1638611963693XmoO  TssA
16xmoP (xmoP)21344..22927 [+], 1584611963694hypothetical protein  PAAR
17xmoQ (xmoQ)22927..23556 [+], 630611963695hypothetical protein 
18xmoR (xmoR)23813..24256 [+], 444611963696hypothetical protein 
19xmoS (xmoS)24626..26386 [+], 1761611963697XmoS  TssF
20xmoT (xmoT)26350..27429 [+], 1080611963698XmoT  TssG
21xmoU (xmoU)27410..27814 [+], 405611963699XmoU  TssJ
22xmoV (xmoV)27950..28378 [+], 429611963700XmoV  TssE
23xmoW (xmoW)28378..29754 [+], 1377611963701XmoW  TssA
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
XmoF (Hcp1) , XmoI (Tle4)

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1xmoF(xmoF)5838..6329 [+], 492611963684Hcp-like protein (Hcp1)XmoF (Hcp1)
2xmoI(xmoI)11678..13447 [+], 1770611963687hypothetical protein (Tle4)XmoI (Tle4)

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Proteins        Genes

Homology Immunity protein list
XmoJ (Tli4)

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1xmoJ(xmoJ)13422..14132 [+], 711611963688hypothetical protein (Tli4)XmoJ (Tli4)

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Proteins        Genes
(1) Ma J et al. (2014). Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972] experimental
 
experimental This literature contains experimental investigation