SecReT6
SecReT6 ID905 experimental
StrainEscherichia coli strain TW-XM
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionKF678350
Location1..25901
CommentT6SS2-associated mutants only presented a significant decrease in the adherence and invasion of mice brain microvascular endothelial cells (BMEC) bEnd.3 and brain tissue of duck infection model.
Functionanti-eukaryotic; effector translocation
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121121211
ComponentTssGTssJTssKTssM
Number1111
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1xmtA (xmtA)1..480 [-], 480611963703Hcp-like protein  TssD
2xmtB (xmtB)498..1940 [-], 1443611963704XmtB  TssA
3xmtC (xmtC)1867..5334 [-], 3468611963705IcmF-like protein  TssM
4xmtD (xmtD)5414..6856 [-], 1443611963706XmtD  TssA
5xmtE (xmtE)6932..7570 [-], 639611963707XmtE 
6xmtF (xmtF)7618..10377 [-], 2760611963708putative ATP-dependent Clp protease  TssH
7xmtG (xmtG)10387..11151 [-], 765611963709XmtG  TssL
8xmtH (xmtH)11156..12502 [-], 1347611963710XmtH  TssK
9xmtI (xmtI)12505..13029 [-], 525611963711XmtI  TssJ
10xmtJ (xmtJ)13026..14306 [-], 1281611963712XmtJ  Fha
11xmtK (xmtK)14323..15372 [-], 1050611963713XmtK  TssG
12xmtL (xmtL)15336..17042 [-], 1707611963714XmtL  TssF
13xmtM (xmtM)17183..17608 [-], 426611963715XmtM  TssE
14xmtN (xmtN)17613..18140 [-], 528611963716XmtN  TssC
15xmtO (xmtO)18334..19098 [-], 765611963717XmtO  TssC
16xmtP (xmtP)19121..19624 [-], 504611963718XmtP  TssB
17xmtQ (xmtQ)20095..20253 [-], 159611963719hypothetical protein 
18xmtR (xmtR)20330..20848 [+], 519611963720Hcp-like protein  TssD
19xmtS (xmtS)21069..23051 [+], 1983611963721XmtS  TssI
20xmtT (xmtT)23158..24204 [+], 1047611963722hypothetical protein 
21xmtU (xmtU)24197..25636 [+], 1440611963723hypothetical protein  PAAR
22xmtV (xmtV)25611..25901 [+], 291611963724hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
   Hcp2 (AHW84519)
Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
(1) Ma J et al. (2014). Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infect Immun. 82(9):3867-79. [PudMed:24980972] experimental
 
experimental This literature contains experimental investigation