SecReT6
SecReT6 ID937 experimental
StrainEscherichia coli DE719
RepliconT6SS [Browse all T6SS(s) in this replicon]
AccessionKM251715
Location1..24039
CommentDotU contributes to intracellular survival in macrophages; DotU and T6SS-2 affect bacterial colonization and survival during infection in vivo
Functionanti-eukaryotic
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number321131211
ComponentTssGTssJTssKTssM
Number1112
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III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1evfA (evfA)501..980 [-], 480700289654EvfA  TssD
2evfB (evfB)998..2356 [-], 1359700289655EvfB  TssA
3evfC (evfC)2367..5384 [-], 3018700289656EvfC  TssM
4evfD (evfD)5416..5895 [-], 480700289657EvfD  TssM
5evfF (evfF)5915..7357 [-], 1443700289659EvfF  TssA
6evfE (evfE)5915..6346 [-], 432700289658EvfE  TssA
7evfG (evfG)7362..8009 [-], 648700289660EvfG 
8evfH (evfH)8102..9160 [-], 1059700289661EvfH  TssH
9evfI (evfI)9115..9744 [-], 630700289662EvfI  TssH
10evfJ (evfJ)9716..10864 [-], 1149700289663EvfJ  TssH
11evfK (evfK)10874..11638 [-], 765700289664EvfFK  TssL
12evfL (evfL)11643..12989 [-], 1347700289665EvfL  TssK
13evfM (evfM)12992..13516 [-], 525700289666EvfM  TssJ
14evfN (evfN)13513..14121 [-], 609700289667EvfN  Fha
15evfO (evfO)14021..14794 [-], 774700289668EvfO  Fha
16evfP (evfP)14811..15860 [-], 1050700289669EvfP  TssG
17evfQ (evfQ)15824..17665 [-], 1842700289670EvfQ  TssF
18evfR (evfR)17671..18096 [-], 426700289671EvfR  TssE
19evfS (evfS)18101..19156 [-], 1056700289672EvfS  TssC
20evfT (evfT)19119..19586 [-], 468700289673EvfT  TssC
21evfU (evfU)19609..20112 [-], 504700289674EvfU  TssB
22evfV (evfV)20818..21336 [+], 519700289675EvfV  TssD
23evfW (evfW)21557..23539 [+], 1983700289676EvfW  TssI
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
   Hcp
Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
(1) Wang S et al. (2014). DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Front Microbiol. 5:588. [PudMed:25426107]