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The biosynthetic gene clusters for thiopeptide antibiotic.

#OrganismThiopeptide (Genotype)No. of Precursor PeptideGene ClusterHomologues to nosiheptide biosynthetic genesSequence Accession No.
1 Actinomadura melliaura SCC 1655 -  (III) 1 gene cluster D E F G H O  DQ297453
2 Actinomyces sp. oral taxon 170 str. F0386 -  (III) 1 gene cluster D E F G  NZ_AFBL01000091
3 Actinomyces viscosus C505 -  (III) 1 gene cluster D E F G  NZ_GL877175
4 Actinosynnema mirum DSM 43827 -  (III) 1 gene cluster D E F G O  NC_013093
5 Bacillus atrophaeus 1942 -  (III) 2 gene cluster D E F G  NC_014639
6 Bacillus cereus ATCC 14579 thiocillin I  (III) 4 gene clusterexperimental D E F G H O  NC_004722
7 Bacillus cereus BDRD-Cer4 -  (III) - gene cluster D E F G H O  NZ_CM000726
8 Bacillus cereus G9241 -  (III) 5 gene cluster D E F G O  NZ_AAEK01000013
9 Bacillus cereus NVH0597-99 -  (III) 5 gene cluster D E F G O  NZ_ABDK02000018
10 Bacillus sp. B14905 -  (III) 3 gene cluster D E F G O  NZ_AAXV01000024
11 Catenulispora acidiphila DSM 44928 -  (III) 1 gene cluster D E F G H  NC_013131
12 Catenulispora acidiphila DSM 44928 -  (III) 1 gene cluster D E F G H  NC_013131
13 Clostridium cellulovorans 743B -  (III) 3 gene cluster D E F G O  NC_014393
14 Corynebacterium diphtheriae 31A -  (III) 1 gene cluster D E F G  NC_016799
15 Corynebacterium diphtheriae BH8 -  (III) 1 gene cluster D E F G  NC_016800
16 Corynebacterium diphtheriae C7 -  (III) 1 gene cluster D E F G  NC_016801
17 Corynebacterium diphtheriae CDCE 8392 -  (III) 1 gene cluster D E F G  NC_016785
18 Corynebacterium diphtheriae HC03 -  (III) 1 gene cluster D E F G  NC_016787
19 Corynebacterium diphtheriae INCA 402 -  (III) 1 gene cluster D E F G  NC_016783
20 Corynebacterium diphtheriae PW8 -  (III) 1 gene cluster D E F G  NC_016789
21 Corynebacterium pseudotuberculosis 316 -  (III) 1 gene cluster D E F G  NC_016932
22 Corynebacterium pseudotuberculosis 3/99-5 -  (III) 1 gene cluster D E F G  NC_016781
23 Corynebacterium pseudotuberculosis FRC41 -  (III) 1 gene cluster D E F G  NC_014329
24 Corynebacterium pseudotuberculosis I19 -  (III) 1 gene cluster D E F G  CP002251
25 Corynebacterium pseudotuberculosis P54B96 -  (III) 1 gene cluster D E F G  NC_017031
26 Corynebacterium ulcerans 809 -  (III) 1 gene cluster D E F G  CP002790
27 Corynebacterium ulcerans BR-AD22 -  (III) 1 gene cluster D E F G  CP002791
28 Frankia sp. CcI3 -  (III) 1 gene cluster D E F G H O  NC_007777
29 Herpetosiphon aurantiacus ATCC 23779 -  (III) 5 gene cluster D E F G H  NC_009972
30 Lactobacillus gasseri JV-V03 -  (III) 1 gene cluster D E F G O  NZ_ACGO02000004
31 Lysinibacillus fusiformis ZC1 -  (III) 1 gene cluster D E F G  ADJR01000053
32 Lysinibacillus sphaericus C3-41 -  (III) 2 gene cluster D E F G O  NC_010382
33 Micromonospora sp. ATCC 39149 -  (II) 1 gene cluster D E F G O  NZ_GG657738
34 Nocardia sp. ATCC 202099 nocathiacin I  (I) 1 gene clusterexperimental D E F G H O  GU564398
35 Nocardiopsis sp. TFS65-07 TP-1161  (III) 2 gene clusterexperimental D E F G H O  HM467197
36 Nonomuraea sp. Bp3714-39 thiomuracins  (III) 1 gene clusterexperimental D E F G H O  FJ461360
37 Nonomuraea sp. WU8817 GE2270A  (III) 1 gene clusterexperimental D E F G H O  FJ461359
38 Propionibacterium acnes HL030PA1 -  (III) 1 gene cluster D E F G O  ADYB01000065
39 Propionibacterium acnes KPA171202 -  (III) 1 gene cluster D E F G O  NC_006085
40 Propionibacterium acnes SK187 -  (III) 1 gene cluster D E F G O  NZ_ADJM01000020
41 Propionibacterium sp. 434-HC2 -  (III) 2 gene cluster D E F G O  NZ_AFIL01000016
42 Salinispora arenicola CNS-205 -  (III) 1 gene cluster D E F G H  NC_009953
43 Salinispora tropica CNB-440 -  (III) 1 gene cluster D E F G H  NC_009380
44 Sorangium cellulosum 'So ce 56' -  (III) - gene cluster D E F G  NC_010162
45 Streptococcus downei F0415 -  (III) 2 gene cluster D E F G  AEKN01000007
46 Streptococcus pneumoniae INV104 -  (III) 1 gene cluster D E F G O  FQ312030
47 Streptomyces actuosus ATCC 25421 nosiheptide  (I) 1 gene clusterexperimental D E F G H O  FJ438820
48 Streptomyces albus J1074 -  (III) 1 gene cluster D E F G H  NZ_DS999645
49 Streptomyces bingchenggensis BCW-1 -  (III) 1 gene cluster D E F G H  CP002047
50 Streptomyces chartreusis NRRL 12338 -  (III) - gene cluster D E F G H O  NZ_AGDE01000052
51 Streptomyces griseus subsp. griseus NBRC 13350 -  (III) 1 gene cluster D E F G H  NC_010572
52 Streptomyces griseus XylebKG-1 -  (III) 1 gene cluster D E F G H  NZ_GL877172
53 Streptomyces hygroscopicus 10-22 cyclothiazomycin  (III) 1 gene clusterexperimental D E F G H O  FJ472825
54 Streptomyces laurentii ATCC 31255 thiostrepton A (A1)  (II) 1 gene clusterexperimental D E F G H O  FJ436358
55 Streptomyces laurentii ATCC 31255 thiostrepton  (II) 1 gene clusterexperimental D E F G H O  FJ652572
56 Streptomyces pristinaespiralis ATCC 25486 -  (III) 1 gene cluster D E F G O  NZ_CM000950
57 Streptomyces sioyaensis ATCC 13989 siomycin A  (II) 1 gene clusterexperimental D E F G H O  FJ436355
58 Streptomyces sp. AA4 -  (III) 1 gene cluster D E F G  NZ_GG657747
59 Streptomyces sp. ATCC 55365 GE37468  (III) 1 gene clusterexperimental D E F G H O  JN052143
60 Streptomyces sp. C -  (III) 1 gene cluster D E F G H  NZ_GG657750
61 Streptomyces sp. NRRL 30471 -  (III) 1 gene cluster D E F G H O  HQ257512
62 Streptomyces venezuelae ATCC 10712 -  (III) 2 gene cluster D E F G H O  FR845719
63 Thermobispora bispora DSM 43833 -  (III) 1 gene cluster D E F G H O  NC_014165
64 Verrucosispora maris AB-18-032 -  (III) 2 gene cluster D E F G H  NC_015434
65 Weissella paramesenteroides ATCC 33313 -  (III) - gene cluster E G O  NZ_ACKU01000026

gene cluster: Biosynthetic gene cluster identified
experimental: Data derived from experimental literature
-  : Unavailable