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According to analysis of the genotypic distinctions in this database,we here provide a genotype-based classification system for thiopeptides by taking account of the biosynthetically specific genes relevant to certain structural manners, as exemplified by Type I featuring the genes encoding indolic acid side ring (i.e. nosiheptide and nocathiacin),Type II possessing those for quinalic acid moiety formation (i.e. thiostrepton and siomycin), and Type III containing none of the above as the mono-macrocyclic members (i.e. thiocillin and GE2270A). These support the postulation that the specific tailoring genes can help define the structural divergence of the predicted thiopeptide before isolation/characterization. [more details]
 
 Type I ?possessing the genes encoding indolic acid side ring  
#ThiopeptideStructure PeptideGene Cluster
1glycothiohexideSCTTCECCCSC
2nocathiacinSCTTCECSCSCSS gene clusterexperimental 
3S-54832SCTTCECSCSCS
4MJ347-81F4SCTTCECSCSCSS
5multhiomycinSCTTCECCCSCSS
6nosiheptideSCTTCECCCSCSS gene clusterexperimental 
 Type II ?featuring the gene coding for quinalic acid moiety formation  
#ThiopeptideStructure PeptideGene Cluster
1siomycinVSSASCTTCICTCSCSS gene clusterexperimental 
2Sch 40832TSSSSCTTCICTCSSSS
3thiopeptinVASASCTTCICTCSCSS
4thiostreptonIASASCTTCICTCSCSS gene clusterexperimental  gene clusterexperimental 
5thiactinSCTMSGCACSSSSS
6Sch 18640IASASCTTCICTCSCSS
768-1147IASASCTTCICTCSCSS
8bryamycinIASASCTTCICTCSCSS
9A-8506IASASCTTCICTCSCSS
 Type III ?No MIA (indolyl), no QA (quinolinic acid)  
#ThiopeptideStructure PeptideGene Cluster
1amythiamicinSCNCVCGVCCSCSP
2GE2270SCNCVCGFCCSCSPSA gene clusterexperimental 
3methylsulfomycinSCTTSGCTSSSSSSSS
4promoinducinSCTTSGCTSSSSSSSSS
5promothiocinSCVGSACASSSSS
6QN3323SCTTCVCTCSCCT
7radamycinSCVGSACACSSSSSS
8sulfomycinSCSTSGCTSSSSSSSS
9thioactinSCTMSGCACSSSSS
10thiocillinSCTTCVCTCSCCTT gene clusterexperimental 
11YM-266183-4SCTTCVCTCSCCTT
12thiomuracinsSCNCFCYICCSCSSA gene clusterexperimental 
13micrococcinSCTTCVCTCSCCTT
14thiotipinSCTTSGCTSSSSSSSS
15JBIR-83-4SCVASACASSS
16TP-1161SCTTSGCACSSSSSS gene clusterexperimental 
17cyclothiazomycinSNCTSTGTPASCCSCCCC gene clusterexperimental 
18berninamycinSCTTSSVSSSSSSSS
19geninthiocinSCTTSSVSSSSSSSS
20nocardithiocinSCTSCVCICSCCT
21thioxamycinSCTMSGCACSSSSSSSS
22GE37468STNCFCYICCSCSSN gene clusterexperimental 
23A10255SCTTSGCACSSSSSSSS


gene cluster: Biosynthetic gene cluster identified
experimental: Data derived from experimental literature