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Organism: Streptomyces actuosus ATCC 25421
Accession No. of Nucleotide Sequence: FJ438820
Location of the putative gene cluster: 5328..14761
    
Thiopeptide Series, Family: series e, nosiheptide
Thiopeptide: nosiheptide  
Thiopeptide genotype: Type I

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
nosA2249..2704
-1
456hypothetical protein[NCBI] [UniProt]
nosB2701..4068
-1
1368cytochrome P450[NCBI] [UniProt]
nosC4083..5309
-1
1227cytochrome P450[NCBI] [UniProt]
nosD5328..6365
-1
1038dehydratasenosD[NCBI] [UniProt]
nosE6352..9114
-1
2763dehydratasenosE[NCBI] [UniProt]
nosF9129..10778
-1
1650NADH oxidasenosF[NCBI] [UniProt]
nosG10830..12800
-1
1971putative cyclodehydratasenosG[NCBI] [UniProt]
nosH12797..14761
-1
1965hypothetical proteinnosH[NCBI] [UniProt]
nosI14763..16097
-1
1335putative acyl-CoA synthetase[NCBI] [UniProt]
nosJ16058..16297
-1
240putative ATP-dependent Clp protease[NCBI] [UniProt]
nosK16294..17106
-1
813putative hydrolase[NCBI] [UniProt]
nosL17114..18316
-1
1203radical SAM:biotin and thiamin synthesis-associated proteinType I thiopeptide-specific[NCBI] [UniProt]
nosM18668..18820
1
153precursor peptide for nosiheptide precursor peptide[NCBI] [UniProt]
nosN18891..20078
1
1188putative methyltransferase[NCBI] [UniProt]
nosO20075..21187
1
1113hypothetical proteinnosO[NCBI] [UniProt]
nosP21497..22468
1
972SARP family pathway specific regulatory protein[NCBI] [UniProt]

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Table 2. Reference
Yu Y et al (2009). Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol. 4(10):855-64. [PudMed:19678698]