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Organism: Streptomyces sioyaensis ATCC 13989
Accession No. of Nucleotide Sequence: FJ436355
Location of the putative gene cluster: 19548..29616
    
Thiopeptide Series, Family: series a and b, siomycin
Thiopeptide: siomycin A  
Thiopeptide genotype: Type II

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
sioA10491..11552
-1
1062putative aminotransferase[NCBI] [UniProt]
sioB11597..12421
-1
825alpha/beta hydrolase fold[NCBI] [UniProt]
sioC12500..14359
-1
1860asparagine synthase[NCBI] [UniProt]
sioD14382..14789
-1
408ester cyclase-likeType II thiopeptide-specific[NCBI] [UniProt]
sioE14834..16066
-1
1233acyl-CoA dehydrogenase domain-containing protein[NCBI] [UniProt]
sioF16090..16974
-1
885putative methyltransferase[NCBI] [UniProt]
sioG17000..17554
-1
555hypothetical protein[NCBI] [UniProt]
sioH17889..18074
1
186propeptideprecursor peptide[NCBI] [UniProt]
sioI18770..19555
1
786putative hydrolase[NCBI] [UniProt]
sioJ19548..22196
1
2649dehydrotasenosE[NCBI] [UniProt]
sioK22193..23197
1
1005dehydrotasenosD[NCBI] [UniProt]
sioL23194..24306
1
1113hypothetical proteinnosO[NCBI] [UniProt]
sioM24303..25967
1
1665NADH oxidasenosF[NCBI] [UniProt]
sioN25964..27676
1
1713hypothetical proteinnosH[NCBI] [UniProt]
sioO27673..29616
1
1944cyclodehydrotasenosG[NCBI] [UniProt]
sioP29594..30943
1
1350cytochrome P450-like enzyme[NCBI] [UniProt]
sioQ30919..32220
1
1302acyl-CoA synthetase[NCBI] [UniProt]
sioR32192..33424
1
1233cytochrome P450[NCBI] [UniProt]
sioS33412..36018
1
2607dehydrotase[NCBI] [UniProt]
sioT36030..37805
1
1776radical SAM domain-containing proteinType II thiopeptide-specific[NCBI] [UniProt]
sioU37802..38569
1
768short-chain dehydrogenase/reductase[NCBI] [UniProt]

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Table 2. Reference
Liao R et al (2009). Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.. Chem Biol. 16(2):141-7. [PudMed:19246004]