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Organism: Streptomyces hygroscopicus 10-22
Accession No. of Nucleotide Sequence: FJ472825
Location of the putative gene cluster: 8700..15613
    
Thiopeptide Series, Family: series d, cyclothiazomycin
Thiopeptide: cyclothiazomycin B1  
Thiopeptide genotype: Type III

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
cltQ384..734
1
351putative transposase[NCBI] [UniProt]
cltP1056..1949
-1
894XRE family transcriptional regulator[NCBI] [UniProt]
cltO2031..3467
1
1437transport protein[NCBI] [UniProt]
cltN3606..3941
1
336ethyl tert-butyl ether degradation protein[NCBI] [UniProt]
cltM4077..4667
1
591hypothetical protein[NCBI] [UniProt]
cltI5069..5647
1
579putative transposase[NCBI] [UniProt]
cltH5831..8629
1
2799LuxR family transcriptional regulator[NCBI] [UniProt]
cltG8700..9827
-1
1128unknownnosO[NCBI] [UniProt]
cltF9932..10957
-1
1026putative lantibiotic biosynthesis proteinnosD[NCBI] [UniProt]
cltE10929..13556
-1
2628lantibiotic dehydratase domain proteinnosE[NCBI] [UniProt]
cltB13571..15613
-1
2043putative docking proteinnosG[NCBI] [UniProt]
cltA15725..15907
-1
183unknown prepeptideprecursor peptide[NCBI] [UniProt]
cltC16069..17757
-1
1689mcbC-like oxidoreductasenosF[NCBI] [UniProt]
cltD17792..19735
-1
1944putative peptidase containing docking domainnosH[NCBI] [UniProt]
cltJ19897..20409
1
513epoxide hydrolase 1[NCBI] [UniProt]
cltK20447..20803
-1
357putative nitroreductase[NCBI] [UniProt]
cltL20970..21206
1
237putative transposase[NCBI] [UniProt]

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Table 2. Reference
Wang J et al (2010). Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol. 76(7):2335-44. [PudMed:20154110]