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Organism: Nonomuraea sp. WU8817
Accession No. of Nucleotide Sequence: FJ461359
Location of the putative gene cluster: 9646..18937
    
Thiopeptide Series, Family: series d, GE2270
Thiopeptide: GE2270A  
Thiopeptide genotype: Type III

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
tpdR1..714
1
714TetR transcriptional regulator[NCBI] [UniProt]
tpdO711..2612
1
1902cyclodehydratase[NCBI] [UniProt]
tpdP2609..5098
1
2490dehydratase[NCBI] [UniProt]
tpdQ5095..6129
1
1035cytochrome P450 monooxygenase[NCBI] [UniProt]
tpdS6218..6904
1
687hypothetical protein[NCBI] [UniProt]
tpdT6947..8065
1
1119N-methyl transferase[NCBI] [UniProt]
tpdU8094..9338
1
1245coproporphyrinogen III oxidase[NCBI] [UniProt]
tpdA9462..9635
1
174GE2270 prepropeptideprecursor peptide[NCBI] [UniProt]
tpdB9646..12129
1
2484dehydratasenosE[NCBI] [UniProt]
tpdC12126..13025
1
900dehydratasenosD[NCBI] [UniProt]
tpdD13025..14026
1
1002hypothetical proteinnosO[NCBI] [UniProt]
tpdE14023..15390
1
1368dehydrogenasenosF[NCBI] [UniProt]
tpdF15378..17204
1
1827hypothetical proteinnosH[NCBI] [UniProt]
tpdG17201..18937
1
1737cyclodehydratasenosG[NCBI] [UniProt]
tpdK18969..19337
1
369hypothetical protein[NCBI] [UniProt]
tpdL19327..20577
1
1251coproporphyrinogen III oxidase[NCBI] [UniProt]
tpdM20579..21598
1
1020O-methyl transferase[NCBI] [UniProt]
tpdN22234..22848
1
615deaminase reductase[NCBI] [UniProt]

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Table 2. Reference
Morris RP et al (2009). Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.. J Am Chem Soc.. 131(16):5946-55. [PudMed:19338336]