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Organism: Streptomyces laurentii ATCC 31255
Accession No. of Nucleotide Sequence: FJ652572
Location of the putative gene cluster: 9377..19951
    
Thiopeptide Series, Family: series a and b, thiostrepton
Thiopeptide: thiostrepton A (A1)  
Thiopeptide genotype: Type II

Table 1. The context of the putative gene cluster involved in the thiopeptide biosynthesis
Gene Position Strand Lenth(bp) Product Note Linkout
tsrU1126..1956
-1
831putative lipase[NCBI] [UniProt]
tsrT2015..3871
-1
1857putative amidotransferase[NCBI] [UniProt]
tsrS4011..4418
-1
408putative NTF-2 family proteinType II thiopeptide-specific[NCBI] [UniProt]
tsrQ4493..5722
-1
1230acyl-CoA dehydrogenase family protein[NCBI] [UniProt]
tsrP5924..6859
-1
936putative methyltransferase[NCBI] [UniProt]
tsrO6930..7481
-1
552hypothetical protein[NCBI] [UniProt]
tsrA7900..8076
1
177thiostrepton prepeptideprecursor peptide[NCBI] [UniProt]
tsrB8593..9384
1
792putative alpha-beta hydrolase fold protein[NCBI] [UniProt]
tsrC9377..12178
1
2802putative lantibiotic dehydratasenosE[NCBI] [UniProt]
tsrD12175..13215
1
1041similar to lantibiotic biosynthesis proteinnosD[NCBI] [UniProt]
tsrE13202..14308
1
1107hypothetical proteinnosO[NCBI] [UniProt]
tsrF14305..16074
1
1770McbC-like proteinnosF[NCBI] [UniProt]
tsrG16071..17909
1
1839hypothetical proteinnosH[NCBI] [UniProt]
tsrH17906..19951
1
2046putative cyclodehydratasenosG[NCBI] [UniProt]
tsrI19929..21353
1
1425cytochrome P450[NCBI] [UniProt]
tsrJ21329..22642
1
1314acyl-CoA ligase family protein[NCBI] [UniProt]
tsrK22752..23942
1
1191cytochrome P450[NCBI] [UniProt]
tsrL24005..26743
1
2739putative lantibiotic dehydratase[NCBI] [UniProt]
tsrM26760..28559
1
1800putative radical-SAM domain containing proteinType II thiopeptide-specific[NCBI] [UniProt]
tsrN28556..29374
1
819short chain dehydrogenase[NCBI] [UniProt]

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Table 2. Reference
Kelly WL et al (2009). Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J Am Chem Soc. 131(12):4327-34. [PudMed:19265401]