SecReT4
T4SS ID377
StrainBrucella abortus bv. 1 str. 9-941
Repliconchromosome II [Browse all T4SS(s) in this replicon]
AccessionNC_006933
Location56598..67031
NameVirB
Functioneffector translocation
ClassificationType IVA; Type P
insolico This T4SS is identified in this study.

T4SS components
ComponentVirB1VirB2VirB3VirB4VirB5VirB6VirB7VirB8VirB9
Number111111111
ComponentVirB10VirB11VirD4
Number110

The information of T4SS components from NC_006933
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1BruAb2_005652911..54314 [-], 140462317015amino acid permease 
2BruAb2_005754532..55683 [-], 115262317016hypothetical protein 
3BruAb2_005855934..56452 [-], 51962317017lipoprotein 
4BruAb2_005956598..57686 [-], 108962317018type IV secretion system protein VirB11  VirB11
5BruAb2_006057667..58833 [-], 116762317019type IV secretion system protein VirB10  VirB10
6BruAb2_006158830..59699 [-], 87062317020type IV secretion system protein VirB9  VirB9
7BruAb2_006259696..60415 [-], 72062317021type IV secretion system protein VirB8  VirB8
8BruAb2_006360418..60591 [-], 17462317022type IV secretion system protein VirB7  VirB7
9BruAb2_006460755..61798 [-], 104462317023type IV secretion system protein VirB6  VirB6
10BruAb2_006561982..62698 [-], 71762317024type IV secretion system protein VirB5  VirB5
11BruAb2_006662703..65198 [-], 249662317025type IV secretion system protein VirB4  VirB4
12BruAb2_006765198..65548 [-], 35162317026type IV secretion system protein VirB3  VirB3
13BruAb2_006865562..65879 [-], 31862317027type IV secretion system protein VirB2  VirB2
14BruAb2_006966315..67031 [-], 71762317028type IV secretion system protein VirB1  VirB1
15BruAb2_007067535..68773 [-], 123962317029transglycosylase 
16BruAb2_0071 (galU)69173..70066 [+], 89462317030GalU, UTP--glucose-1-phosphate uridylyltransferase 
17BruAb2_007270119..71657 [-], 153962317031hypothetical protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes

Effectors
BtpB, BPE043, VceC, BPE275, RicA, VceA, BPE005, BPE123

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1BruAb1_0752 742846..743724 [+], 87962289692hypothetical proteinexperimental  BtpBinteraction
2BruAb1_1029 1007678..1012339 [-], 466262289947hypothetical protein  BPE043
3BruAb1_1043 1021454..1022710 [-], 125762289960hypothetical protein  VceC
4BruAb1_1259 1240195..1240956 [-], 76262290165rhomboid family protein  BPE275
5BruAb1_1263 1242884..1243411 [-], 52862290169ferripyochelin-binding protein  RicA
6BruAb1_1622 1599606..1599923 [+], 31862290510hypothetical protein  VceA
7BruAb1_1980 1944534..1944995 [-], 46262290852cyclic nucleotide-binding protein  BPE005
8BruAb2_0122 121589..122050 [-], 46262317077hypothetical protein  BPE123

interaction This effector contains information of interaction.

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Proteins        Genes
The information on host-pathogen interaction.

#Name(Protein GI)Host site/SubstrateFunctionReference
1BtpB (62289692)MYD88BtpB may interact with MYD88 to inhibit TLR signaling and interfere with activation of dendritic cells.(1) PubMed: 23847770insolico

insolico This T4SE is highly identical with the protein mentioned in the literature.
(1) Salcedo SP et al. (2013). BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. . Front. Cell. Infect. Microbiol. . 2013.00028 . [PudMed:23847770] experimental
Identified as part of this study from NC_006933