I. Summary

SecReT6 ID	111
Strain	Burkholderia thailandensis E264
Replicon	chromosome II [Browse all T6SS(s) in this replicon]
Accession	NC_007650
Location	137720..169613
Comment
Function	N/A
T6SS Type	Type i; subtype i3
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	2	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	BTH_RS00590	132907..133461 [+], 555	499720066	type 1 fimbrial protein
2	BTH_RS00595	133543..134268 [+], 726	499720067	fimbria/pilus periplasmic chaperone
3	BTH_RS34170	134317..134475 [-], 159	1807074601	hypothetical protein
4	BTH_RS00600	134428..137124 [+], 2697	497580537	fimbrial biogenesis outer membrane usher protein
5	BTH_RS00605	137117..137689 [+], 573	648185552	type 1 fimbrial protein
6	BTH_RS00610	137720..138409 [+], 690	497592905	DotU family type IV/VI secretion system protein	TssL
7	BTH_RS00615	138412..140088 [+], 1677	497580543	OmpA family protein	TagL
8	BTH_RS00620 (tssB)	140432..140971 [+], 540	497580544	type VI secretion system contractile sheath small subunit	TssB
9	BTH_RS00625 (tssC)	141005..142504 [+], 1500	497580545	type VI secretion system contractile sheath large subunit	TssC
10	BTH_RS00630	142705..143187 [+], 483	497580546	type VI secretion system tube protein Hcp	TssD
11	BTH_RS00635 (tssJ)	143315..143857 [+], 543	499720069	type VI secretion system lipoprotein TssJ	TssJ
12	BTH_RS00640 (tssK)	143863..145212 [+], 1350	497580548	type VI secretion system baseplate subunit TssK
13	BTH_RS00645 (tssL)	145209..146510 [+], 1302	497580549	type VI secretion system protein TssL, long form	TssL
14	BTH_RS00650 (tssM)	146525..150433 [+], 3909	497580552	type VI secretion system membrane subunit TssM	TssM
15	BTH_RS00655	150603..151172 [+], 570	497580554	hypothetical protein
16	BTH_RS00660 (tssI)	151273..153891 [+], 2619	499720071	type VI secretion system tip protein VgrG	TssI
17	BTH_RS00665	153966..154235 [+], 270	490658703	PAAR domain-containing protein	PAAR
18	BTH_RS00670	154248..157700 [+], 3453	499720072	RHS repeat protein
19	BTH_RS00675	157593..158951 [-], 1359	740922510	hypothetical protein
20	BTH_RS00680	158984..160012 [-], 1029	497580566	fimbrial protein
21	BTH_RS00685	160068..161138 [-], 1071	497580567	type VI secretion system ImpA family N-terminal domain-containing protein	TssA
22	BTH_RS00690 (tssG)	161157..162206 [-], 1050	497580569	type VI secretion system baseplate subunit TssG	TssG
23	BTH_RS00695 (tssF)	162203..164083 [-], 1881	497580571	type VI secretion system baseplate subunit TssF	TssF
24	BTH_RS00700 (tssE)	164085..164603 [-], 519	497580573	type VI secretion system baseplate subunit TssE	TssE
25	BTH_RS00705	164590..165396 [-], 807	497580574	ImpE protein
26	BTH_RS00710	165428..166411 [-], 984	1844068774	TagK domain-containing protein
27	BTH_RS00715 (tssH)	166968..169613 [+], 2646	497592915	type VI secretion system ATPase TssH
28	BTH_RS00720	170006..173047 [-], 3042	644827693	response regulator
29	BTH_RS29330	173846..174040 [-], 195	497592916	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

N/A

N/A

(1) Russell AB et al. (2012). A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe. 11(5):538-49. [PudMed:22607806]

(2) Schwarz S et al. (2010). Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog. 6(8):e1001068. [PudMed:20865170]

This literature contains experimental investigation

This literature contains bioinformatics investigation