I. Summary
SecReT6 ID112 insolico
StrainBurkholderia thailandensis E264
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BTH_RS01280299015..299911 [-], 897499720115LysR family transcriptional regulator 
2BTH_RS01285300115..300819 [+], 705497580812SDR family oxidoreductase 
3BTH_RS01290301071..303068 [+], 1998497580814DUF3857 and transglutaminase domain-containing protein 
4BTH_RS01295 (tagH)303044..304489 [-], 1446497580816type VI secretion system-associated FHA domain protein TagH 
5BTH_RS01300304544..304942 [-], 399497592957TssQ family T6SS-associated lipoprotein 
6BTH_RS01305 (tssJ)305598..306116 [+], 519497580820type VI secretion system lipoprotein TssJ  TssJ
7BTH_RS01310 (tssK)306113..307519 [+], 1407497580822type VI secretion system baseplate subunit TssK  TssK
8BTH_RS01315307535..308848 [+], 1314497580824DotU family type VI secretion system protein  TssL
9BTH_RS01320 (tssM)308851..312480 [+], 3630497580826type VI secretion system membrane subunit TssM  TssM
10BTH_RS01325 (tagF)312477..313352 [+], 876497580828type VI secretion system-associated protein TagF 
11BTH_RS01330313510..316143 [+], 2634497580830protein kinase 
12BTH_RS01335 (tssA)316196..317260 [+], 1065497580831type VI secretion system protein TssA  TssA
13BTH_RS01340 (tssB)317322..317903 [+], 582497580833type VI secretion system contractile sheath small subunit  TssB
14BTH_RS01345 (tssC)317896..319404 [+], 1509497580835type VI secretion system contractile sheath large subunit  TssC
15BTH_RS01350319462..319953 [+], 492497580837type VI secretion system tube protein Hcp  TssD
16BTH_RS01355 (tssE)319972..320532 [+], 561497580839type VI secretion system baseplate subunit TssE  TssE
17BTH_RS01360 (tssF)320537..322408 [+], 1872497580844type VI secretion system baseplate subunit TssF  TssF
18BTH_RS01365 (tssG)322372..323688 [+], 1317497580846type VI secretion system baseplate subunit TssG 
19BTH_RS01370 (tssH)323701..326358 [+], 2658497580848type VI secretion system ATPase TssH  TssH
20BTH_RS01375 (tssI)326355..328559 [+], 2205497580850type VI secretion system tip protein VgrG 
21BTH_RS01380328575..329840 [+], 1266497580852hypothetical protein 
22BTH_RS01385329863..334482 [+], 4620497580853RHS domain-containing protein 
23BTH_RS29390334730..335177 [-], 448pseudogenetransposase 
24BTH_RS01400335205..336473 [-], 1269499720121IS256 family transposase 
25BTH_RS01405336667..337332 [-], 666497580862HAD-IA family hydrolase 
26BTH_RS01415 (nudK)337540..338136 [-], 597490675673GDP-mannose pyrophosphatase NudK 
27BTH_RS01420338150..338484 [-], 335pseudogenehypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

(1) Russell AB et al. (2012). A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe. 11(5):538-49. [PudMed:22607806] experimental in_silico
(2) Schwarz S et al. (2010). Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog. 6(8):e1001068. [PudMed:20865170] experimental
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation