I. Summary

SecReT6 ID	120
Strain	Escherichia coli UTI89
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_007946
Location	237565..271647
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	2	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	UTI89_C0226 (dkgB)	233915..234718 [+], 804	91209275	2,5-diketo-D-gluconate reductase B
2	UTI89_C0227	234715..235629 [-], 915	91209276	LysR family transcriptional regulator
3	UTI89_C0228 (yafD)	235846..236670 [+], 825	91209277	hypothetical protein
4	UTI89_C0229 (yafE)	236748..237518 [+], 771	91209278	hypothetical protein
5	UTI89_C0230 (mltD)	237565..238923 [-], 1359	91209279	membrane-bound lytic murein transglycosylase D
6	UTI89_C0231 (gloB)	238995..239750 [-], 756	91209280	hydroxyacylglutathione hydrolase
7	UTI89_C0232 (yafS)	239766..240506 [+], 741	91209281	hypothetical protein
8	UTI89_C0233 (rnhA)	240503..241081 [-], 579	91209282	ribonuclease H
9	UTI89_C0234 (dnaQ)	241026..241766 [+], 741	91209283	DNA polymerase III subunit epsilon
10	UTI89_C0236 (yafT)	242304..243089 [+], 786	91209284	aminopeptidase
11	UTI89_C0237	243429..243908 [-], 480	91209285	hypothetical protein	TssD
12	UTI89_C0238	243926..245368 [-], 1443	91209286	hypothetical protein	TssA
13	UTI89_C0239	245295..248762 [-], 3468	91209287	hypothetical protein	TssM
14	UTI89_C0240	248842..250284 [-], 1443	91209288	hypothetical protein	TssA
15	UTI89_C0241	250289..251032 [-], 744	91209289	hypothetical protein
16	UTI89_C0242	251029..253788 [-], 2760	91209290	hypothetical protein	TssH
17	UTI89_C0243	253798..254562 [-], 765	91209291	hypothetical protein	TssL
18	UTI89_C0244	254567..255913 [-], 1347	91209292	hypothetical protein	TssK
19	UTI89_C0245	255916..256440 [-], 525	91209293	hypothetical protein	TssJ
20	UTI89_C0246	256437..257729 [-], 1293	91209294	hypothetical protein	Fha
21	UTI89_C0247	257734..258783 [-], 1050	91209295	hypothetical protein	TssG
22	UTI89_C0248	258747..260588 [-], 1842	91209296	hypothetical protein	TssF
23	UTI89_C0249	260594..261019 [-], 426	91209297	hypothetical protein	TssE
24	UTI89_C0250	261024..262508 [-], 1485	91209298	hypothetical protein	TssC
25	UTI89_C0251	262531..263034 [-], 504	91209299	hypothetical protein	TssB
26	UTI89_C0252	263740..264258 [+], 519	91209300	hypothetical protein	TssD
27	UTI89_C0253	264479..266461 [+], 1983	91209301	hypothetical protein	TssI
28	UTI89_C0254	266568..267614 [+], 1047	91209302	hypothetical protein
29	UTI89_C0255	267607..269046 [+], 1440	91209303	hypothetical protein	PAAR
30	UTI89_C0256	269021..269311 [+], 291	91209304	hypothetical protein
31	UTI89_C0257	270562..271065 [+], 504	91209305	hypothetical protein
32	UTI89_C0258	271135..271647 [+], 513	91209306	hypothetical protein
33	UTI89_C0259	271918..272697 [-], 780	91209307	hypothetical protein
34	UTI89_C0260 (ykfE)	272842..273315 [+], 474	91209308	C-lysozyme inhibitor
35	UTI89_C0261 (fadE)	273358..275802 [-], 2445	162138493	acyl-CoA dehydrogenase
36	UTI89_C0262 (gmhA)	276042..276620 [+], 579	162138492	phosphoheptose isomerase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files

Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

ECA2866

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	UTI89_C0252	263740..264258 [+], 519	91209300	hypothetical protein	ECA2866

Download FASTA format files

Proteins        Genes

N/A

(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603]

This literature contains bioinformatics investigation