I. Summary
SecReT6 ID121 insolico
StrainEscherichia coli UTI89
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i2
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1UTI89_C3176 (fucU)3093393..3093815 [+], 42391212173protein of fucose operon 
2UTI89_C3177 (fucR)3093864..3094604 [+], 74191212174DNA-binding transcriptional activator FucR 
3UTI89_C3178 (ygdE)3094648..3095748 [-], 110191212175RNA 2'-O-ribose methyltransferase 
4UTI89_C3179 (ygdD)3095741..3096043 [-], 30391212176hypothetical protein 
5UTI89_C3180 (gcvA)3096155..3097072 [-], 91891212177DNA-binding transcriptional activator GcvA 
6UTI89_C31813097390..3097683 [+], 29491212178hypothetical protein 
7UTI89_C31823097423..3097653 [-], 23191212179hypothetical protein 
8UTI89_C31833097806..3099047 [+], 124291212180cysteine sulfinate desulfinase 
9UTI89_C3184 (ygdK)3099047..3099490 [+], 44491212181hypothetical protein 
10UTI89_C3185 (ygdL)3099541..3100347 [-], 80791212182hypothetical protein 
11UTI89_C3186 (mltA)3100424..3101521 [-], 1098162138382murein transglycosylase A 
12UTI89_C31903102641..3103162 [+], 52291212184hypothetical protein  TssB
13UTI89_C31913103215..3104759 [+], 154591212185hypothetical protein  TssC
14UTI89_C31923104777..3106114 [+], 133891212186hypothetical protein  TssK
15UTI89_C31933106111..3106776 [+], 66691212187hypothetical protein  TssL
16UTI89_C31943106789..3108441 [+], 165391212188hypothetical protein  TagL
17UTI89_C31953108478..3109080 [-], 60391212189hypothetical protein 
18UTI89_C31963108499..3108990 [+], 49291212190secreted protein Hcp  TssD
19UTI89_C31973109182..3111827 [+], 264691212191ClpB protein  TssH
20UTI89_C31983111839..3114319 [+], 248191212192hypothetical protein  TssI
21UTI89_C31993114339..3116108 [+], 177091212193hypothetical protein  Tle4 (e)
22UTI89_C32003116083..3116916 [+], 83491212194hypothetical protein  Tli4 (i)
23UTI89_C32013116885..3117178 [+], 29491212195hypothetical protein 
24UTI89_C32023117642..3117902 [+], 26191212196hypothetical protein  PAAR
25UTI89_C32033117829..3119040 [+], 121291212197hypothetical protein 
26UTI89_C32043119050..3122403 [+], 335491212198hypothetical protein  TssM
27UTI89_C32053122369..3124006 [+], 163891212199hypothetical protein  TssA
28UTI89_C32063125577..3126218 [+], 64291212200hypothetical protein 
29UTI89_C32073126499..3126918 [+], 42091212201hypothetical protein 
30UTI89_C32083130072..3130608 [+], 53791212202hypothetical protein  TssJ
31UTI89_C32093130612..3131040 [+], 42991212203hypothetical protein  TssE
32UTI89_C32103131040..3132416 [+], 137791212204hypothetical protein  TssA
33UTI89_C32113131590..3131742 [-], 15391212205hypothetical protein 
34UTI89_C32123132718..3133674 [-], 957912122062-hydroxyacid dehydrogenase 
35UTI89_C32133133737..3134333 [-], 59791212207phosphosugar isomerase 
36UTI89_C32143134336..3135511 [-], 117691212208beta-cystathionase 
37UTI89_C32153135511..3137091 [-], 158191212209PTS system maltose and glucose-specific transporter subunit IIABC 
38UTI89_C32163137123..3137992 [-], 87091212210antiterminator 
39UTI89_C32173138031..3138183 [+], 15391212211hypothetical protein 
40UTI89_C3218 (amiC)3138193..3139536 [-], 134491212212N-acetylmuramoyl-L-alanine amidase 
41UTI89_C3219 (argA)3139678..3141009 [+], 1332162138381N-acetylglutamate synthase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
EC042_4529 , AHW84487

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1UTI89_C31963108499..3108990 [+], 49291212190secreted protein Hcp EC042_4529
2UTI89_C31993114339..3116108 [+], 177091212193hypothetical protein AHW84487

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Proteins        Genes

Homology Immunity protein list

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1UTI89_C32003116083..3116916 [+], 83491212194hypothetical protein AHW84488

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Proteins        Genes
(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation